A New Anti-Oedematogenic Nor-pregnane Derivative Isolated from Mandevilla illustris

Rivaldo Niero; Ricardo Vieira Alves; Valdir Cechinel Filho; João Batista Calixto; Jane E. Hawkes; Antonio Euzébio Goulart Sant’Ana; Rosendo Augusto Yunes

doi:10.1055/s-2002-34409

Planta Med 2002; 68(9): 850-853
DOI: 10.1055/s-2002-34409

Letter

A New Anti-Oedematogenic Nor-pregnane Derivative Isolated from Mandevilla illustris

Rivaldo Niero¹ , Ricardo Vieira Alves² , Valdir Cechinel Filho¹ , João Batista Calixto² , Jane E. Hawkes³ , Antonio Euzébio Goulart Sant’Ana⁴ , Rosendo Augusto Yunes²

¹Núcleo de Investigações Químico Farmacêuticas (NIQFAR), Curso de Farmácia/CCS, Universidade do Vale do Itajaí (UNIVALI), Itajaí, SC, Brazil
²Departamentos de Química e Farmacologia, Universidade Federal de Santa Catarina (UFSC), Florianópolis, SC, Brazil
³Department of Chemistry, King’s College, University of London, Strand, London, UK
⁴Departamento de Química-CCEN, Universidade Federal de Alagoas (UFAL), Maceió, AL, Brazil

Abstract

A new nor-pregnane derivative (2,6-dideoxy-3-O-methylpyranosylillustrol) (1), isolated from the ethyl acetate extract of Mandevilla illustris rhizomes, was identified by conventional spectral analysis and by chemical means. It markedly inhibited the rat paw oedema induced by carrageenan and, to a lesser extent, those induced by dextran, without affecting that caused by bradykinin.

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References

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Prof. Dr. Rivaldo Niero

Núcleo de Investigações Químico-Farmacêuticas (NIQFAR)

CCS, Universidade do Vale do Itajaí (UNIVALI)

88.302-202, Itajaí

SC, Brazil

Fax: +47-341-7601

Email: niero@ccs.univali.br