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Planta Med 2002; 68(3): 268-271
DOI: 10.1055/s-2002-23143
Letter

© Georg Thieme Verlag Stuttgart · New York

Evaluation of the Anti-Inflammatory Effect of Baicalein on Dextran Sulfate Sodium-Induced Colitis in Mice

Tie Hong1 , Guang-Bi Jin2 , Shigefumi Cho1 , Jong-Chol Cyong1
  • 1Department of Bioregulatory Function, University of Tokyo Graduate School of Medicine, Tokyo, Japan
  • 2Department of Geriatrics, University of Tokyo Graduate School of Medicine, Tokyo, Japan
Further Information

Publication History

March 30, 2001

September 21, 2001

Publication Date:
25 March 2002 (online)

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Abstract

The anti-inflammatory effect of three flavonoids from the root of Scutellaria baicalensis (baicalein, baicalin and wogonin) was evaluated in a murine model of acute experimental colitis induced by dextran sulfate sodium (DSS). Baicalein, but not baicalin or wogonin, given orally at 20 mg/kg for ten days, ameliorates all the considered inflammatory symptoms of the induced colitis, such as body weight loss, blood haemoglobin content, rectal bleeding and other histological and biochemical parameters. The effect of baicalein was similar to that of sulfasalazine, the reference drug given at 50 mg/kg.

References

  • 1 Podolsky D K. Inflammatory bowel disease.  N. Engl. J. Med.. 1991;  325 1008-16
    PubMedGoogle Scholar
  • 2 Egger B, Bajaj-Elliott M, MacDonald T T, Inglin R, Eysselein V E, Buchler M W. Characterisation of acute murine dextran sodium sulphate colitis: cytokine profile and dose dependency.  Digestion. 2000;  62 240-8
    CrossrefPubMedGoogle Scholar
  • 3 Tokoi S, Ohkusa T, Okayasu I, Nakamura K. Population changes in immunoglobulin-containing mononuclear cells in dextran sulfate sodium-induced colitis.  J. Gastroenterol.. 1996;  31 182-8
    PubMedGoogle Scholar
  • 4 Miceli R, Hubert M, Santiago G, Yao D L, Coleman T A, Huddleston K A, Connolly K. Efficacy of keratinocyte growth factor-2 in dextran sulfate sodium-induced murine colitis.  J. Pharmacol. Exp. Ther.. 1999;  290 464-71
    PubMedGoogle Scholar
  • 5 Peppercorn M A. Sulfasalazine. Pharmacology, clinical use, toxicity, and related new drug development.  Ann. Intern. Med.. 1984;  101 377-86
    PubMedGoogle Scholar
  • 6 Hong T, Kobayashi T, Song Q H, Cyong J C. Immunomodulatory action of Oren-gedoku-to on murine colitis model induced by TNBs.  J. Traditional Medicines. 1999;  15 388-9
    PubMedGoogle Scholar
  • 7 Hong T, Jin G B, Kobayashi T, Song Q H, Cyong J C. Effect of Oren-gedoku-to (Huang-Lian-Jie-Du-Tang) on the murine colitis induced by dextran sulfate sodium.  J. Traditional Medicines. 2000;  17 66-72
    PubMedGoogle Scholar
  • 8 Hong T, Jin G B, Cyong J C. Effect of components of Oren-gedoku-to (Huang-Lian-Jie-Du-Tang) on the murine colitis induced by dextran sulfate sodium.  J. Traditional Medicines. 2000;  17 173-9
    PubMedGoogle Scholar
  • 9 Lin C C, Shieh D E. The anti-inflammatory activity of Scutellaria rivularis extracts and its active components, baicalin, baicalein and wogonin.  Am. J. Chin. Med.. 1996;  24 31-6
    CrossrefPubMedGoogle Scholar
  • 10 Kojouharoff G, Hans W, Obermeier F, Mannel D N, Andus T, Scholmerich J, Gross V, Falk W. Neutralization of tumour necrosis factor (TNF) but not of IL-1 reduce inflammation in chronic dextran sulfate sodium-induced colitis in mice.  Clin. Exp. Immunol.. 1997;  107 353-8
    PubMedGoogle Scholar
  • 11 Obermeier F, Kojouharoff G, Hans W, Scholmerich J, Gross V, Falk W. Interferon-gamma (IFN-γ) and tumour necrosis factor (TNF)-induced nitric oxide as toxic effector molecule in chronic dextran sulfate sodium (DSS)-induced colitis in mice.  Clin. Exp. Immunol.. 1999;  116 238-45
    CrossrefPubMedGoogle Scholar
  • 12 Neurath M F, Fuss I, Kelsall B L, Stuber E, Strober W. Antibodies to interleukin 12 abrogate established experimental colitis in mice.  J. Exp. Med.. 1995;  182 1281-90
    CrossrefPubMedGoogle Scholar
  • 13 Reinecker H C, Steffen M, Witthoeft T, Pflueger I, Schreiber S, MacDermott R P, Raedler A. Enhanced secretion of tumour necrosis factor-alpha, IL-6, and IL-1 beta by isolated lamina propria mononuclear cells from patients with ulcerative colitis and Crohn's disease.  Clin. Exp. Immunol.. 1993;  94 174-81
    PubMedGoogle Scholar
  • 14 Seder R A, Gazzinelli R, Sher A, Paul W E. Interleukin-12 acts directly on CD4+ T cells to enhance priming for interferon γ production and diminishes interleukin-4 inhibition of such priming.  Proc. Natl. Acad. Sci. USA. 1993;  90 10188-92
    PubMedGoogle Scholar
  • 15 West G A, Matsuura T, Levine A D, Klein J S, Fiocchi C. Interleukin-4 in inflammatory bowel disease and mucosal immune reactivity.  Gastroenterol.. 1996;  110 1683-95
    PubMedGoogle Scholar
  • 16 Takizawa H, Shintani N, Natsui M, Sasakawa T, Nakakubo H, Nakajima T, Asakura H. Activated immunocompetent cells in rat colitis mucosa induced by dextran sulfate sodium and not complete but partial suppression of colitis by FK 506.  Digestion. 1995;  56 259-64
    PubMedGoogle Scholar
  • 17 Kitajima S, Takuma S, Morimoto M. Changes in colonic mucosal permeability in mouse colitis induced with dextran sulfate sodium.  Exp. Anim.. 1999;  48 137-43
    CrossrefPubMedGoogle Scholar
  • 18 Kato S, Hokari R, Matsuzaki K, Iwai A, Kawaguchi A, Nagao S, Miyahara T, Itoh K, Ishii H, Miura S. Amelioration of murine experimental colitis by inhibition of mucosal addressin cell adhesion molecule-1.  J. Pharmacol. Exp. Ther.. 2000;  295 183-9
    PubMedGoogle Scholar

Tie Hong

Department of Bioregulatory Function

University of Tokyo

Graduate School of Medicine

7-3-1 Hongo, Bunkyo-Ku

Tokyo 113-8655

Japan

Email: tie-tky@umin.ac.jp

Fax: (Japan: +81) 3-3818-4754

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