Horm Metab Res 2002; 34(1): 32-35
DOI: 10.1055/s-2002-19964
Original Clinical

© Georg Thieme Verlag Stuttgart · New York

A Blood Pressure Cut-Off Level Identified for Renal Failure, but not for Macrovascular Complications in Type 2 Diabetes: A 10-year Observation Study

O.  Torffvit 1 , C.-D.  Agardh 2
  • 1Departments of Medicine, University Hospital, Lund, Sweden
  • 2Departments of Endocrinology, University Hospital MAS, Malmö, Sweden
Further Information

Publication History

23 January 2001

2 August 2001

Publication Date:
14 August 2002 (online)

Abstract

Aims: Can a cut-off blood pressure level for major complications be identified?

Methods: A 10 years observation study in 385 type 2 diabetic patients.

Results: 158 patients were affected with myocardial infarction, stroke, renal failure or death, which occurred in 68, 55, 19 and 109 patients, respectively. No patient with a blood pressure below 140 mmHg and/or a diastolic blood pressure below 75 mmHg developed uraemia during the observation period. No such cut-off level was seen for myocardial infarction, stroke or death.

Conclusions: This study shows that there seems to be a cut-off level for blood pressure for development of renal failure, while no level was found for cardio- or cerebrovascular disorders.

References

  • 1 UK Prospective Diabetes Study Group. Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38.  BMJ 1998 317: 703-713
  • 2 Agardh C-D, Agardh E, Torffvit O. The prognostic value of albuminuria for the development of cardiovascular disease and retinopathy: a 5-year follow-up study of 451 patients with type 2 diabetes mellitus.  Diab Res Clin Pract. 1996;  32 35-44
  • 3 Sasaki A, Horiuchi N, Hasagawa K, Uehara M. Persistent albuminuria as an index of diabetic nephropathy in type 2 diabetic patients in Osaka, Japan - incidence, risk factors, prognosis and causes of death.  Diab Res Clin Pract. 1989;  7 299-306
  • 4 MacLeod J M, Lutale J, Marshall S M. Albumin excretion and vascular death in NIDDM.  Diabetologia. 1995;  38 610-616
  • 5 Hanefeld M, Fischer S, Julius U, Schulze J, Schwanebeck U, Schmechel H. et al . Risk factors for myocardial infarction and death in newly detected NIDDM: the Diabetes Intervention Study, 11-year follow-up.  Diabetologia. 1996;  39 1577-1583
  • 6 Walters D P, Gatling W, Houston A C, Mullee M A, Julious S A, Hill R D. Mortality in diabetic subjects: an eleven-year follow-up of a community-based population.  Diabetic Med. 1994;  11 968-973
  • 7 Niskanen L K, Parviainen M, Penttilä I, Uusitupa M IJ. Evolution, risk factors, and prognostic implications of albuminuria in NIDDM.  Diabetes Care. 1996;  19 486-493
  • 8 Standl E, Balletshofer B, Dahl B, Weichenhain B, Stiegler H, Hörmann A, Holle R. Predictors of 10-year macrovascular and overall mortality in patients with NIDDM: the Munich general practitioner project.  Diabetologia. 1996;  39 1540-1545
  • 9 Damsgaard E M, Frøland A, Jørgensen O D, Mogensen C E. Eight to nine year mortality on known non-insulin dependent diabetics and controls.  Kidney Int. 1992;  41 731-735
  • 10 Hasslacher C, Bostedt-Kiesel A, Kempe H P, Wahl P. Effect of metabolic factors and blood pressure on kidney function in proteinuric type 2 (non-insulin-dependent) diabetic patients.  Diabetologia. 1993;  36 1051-1056

O. Torffvit, M.D., Ph.D.

Department of Medicine · University Hospital

221 85 Lund · Sweden

Phone: + 46 (46) 2220702

Fax: + 46 (46) 2110908

Email: Ole.Torffvit@med.lu.se

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