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Horm Metab Res 2002; 34(1): 13-15
DOI: 10.1055/s-2002-19960
Original Basic

© Georg Thieme Verlag Stuttgart · New York

Resistance of Succinic Acid Dimethyl Ester Insulinotropic Action to Exendin (9-39) Amide

J.  Cancelas 1 , J.  A.  García-Martínez 1 , M.  L.  Villanueva-Peñacarrillo 1 , I.  Valverde 1 , W.  J.  Malaisse 2
  • 1Fundación Jiménez Diaz, Madrid, Spain
  • 2Laboratory of Experimental Medicine, Brussels Free University, Brussels, Belgium
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Publication History

2 May 2001

20 August 2001

Publication Date:
14 August 2002 (online)

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Abstract

Exendin (9-39) amide (Ex [9-39]) was recently proposed for use in the treatment of alimentary or reactive hypoglycaemia. It was indeed found to antagonise the insulinotropic action of GLP-1 in rats infused with the dimethyl ester of succinic acid (SAD). We have now investigated whether, under comparable experimental conditions, Ex (9-39) also opposes the insulin-releasing action of SAD itself. Since this was not the case, Ex (9-39) could be safely used to abolish the incretin effect of GLP-1 without interfering with the control of insulin secretion by circulating nutrients.

Key words

Exendin (9-39) Amide - Succinic Acid Dimethyl Ester - Insulin Secretion - Anaesthetized Rats

References

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Prof. W. J. Malaisse

Lab. de Médecine Experimentale · Université Libre de Bruxelles

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