Zusammenfassung
Zur tierexperimentellen Erforschung der Zusammenhänge zwischen Trauma und laborchemisch
erfassbarer Traumaantwort wurde ein Modell entwickelt, welches bei einem Schermechanismus
und Stempelstoß C2- und C3-Frakturen mit I° offenem Weichteilschaden am Hinterlauf
eines Schafes erzeugt. Da keine invasiven oder operativen Vorbereitungen notwendig
sind, ist die laborchemisch erfassbare Systemveränderung ausschließlich auf das standardisierte
Trauma zurückzuführen. Gleichzeitig werden durch die standardisiert einwirkenden Kräfte
gleichförmige Verletzungsmuster erzeugt, welche zur Erforschung operativer Versorgungen
von Defektfrakturen genutzt werden können.
A New Fracture Model to Produce a Combined Soft Tissue- and Bone Trauma in Sheep
We developed a new trauma model to examinate the connection between trauma and laboratory
findings as trauma response in an animal experiment. A transverse mechanism by impact
force produced C2 and C3 fractures with I° open soft tissue injury in hind leg of
sheep. Because there are no invasive preparations necessary the laboratory findings
are only responsed to the trauma. Also the injury of bone and soft tissue is constant
to examinate the operative treatment of defect fractures.
Literatur
- 1
Anderson D E, St Jean G, Richardson D C, DeBowes R M, Roush J K, Lowry S R, Toll P W,
Aberman H M, Van Sickle D C, Hoskinson J J.
Improved osseointeraction of calcium phosphate-coated external fixation pins. Studies
in calves.
Acta Orthop Scand.
1997;
68
571-576
- 2
Aronson J, Shen X C, Skinner R A, Hogue W R, Badger T M, Lumpkin C K.
Rat model of distraction osteogenesis.
J Orthop Res.
1997;
15
221-226
- 3
Augat P, Margevicius K, Simon J, Wolf S, Suger G, Claes L.
Local tissue properties in bone healing: influence of size and stability of the osteotomy
gap.
J Orthop Res.
1998;
16
475-481
- 4
Augat P, Merk J, Genant H K, Claes L.
Quantitative assessment of experimental fracture repair by peripheral computed tomography.
Calcif Tissue Int.
1997;
60
194-199
- 5
Baumgaertel F, Perren S M, Rahn B.
Experimental Investigations on Biological Plate Fixation of Comminuted Femur Fractures
in Sheep.
Unfallchirurg.
1994;
97
19-27
- 6
Carls J, Kohn D, Kirsch L, Carls G.
An in-vitro Model for Initiation for Femur Fractures and Strenght Measurement of Cerclage
Systems.
Z Orthop.
1998;
136
126-131
- 7
Claes L, Heitemeyer U, Krischak G, Braun H, Hierholzer G.
Fixation Technique Influences Osteogenesis of Comminuted Fractures.
Clin Orthop Rel Res.
1999;
365
221-229
- 8
Claes L, Augat P, Suger G, Wilke H J.
Influence of size and stability of the osteotomy gap on the success of fracture healing.
J Orthop Res.
1997;
15
577-584
- 9
Duda G N, Eckert Hubner K, Sokiranski R, Kreutner A, Miller R, Claes L.
Analysis of inter-fragmentary movement as a function of musculoskeletal loading conditions
in sheep.
J Biomech.
1998;
31
201-210
- 10
Duwelius P J, Huckfeldt R, Mullins R J, Shiota T, Woll T S, Lindsey K H, Wheeler D.
The effects of femoral intramedullary reaming on pulmonary function in a sheep lung
model.
J Bone Joint Surg Am.
1997;
79
194-202
- 11
Hillard P J, Harrison A J, Atkins R M.
The yielding of tensioned fine wires in the Ilizarov frame.
Proc Inst Mech Eng H.
1998;
212
37-47
- 12
Hudson J W, Russell R M, Gerhard D A, Lake H P.
Experimentally Induced Upper Fascial Third Fracture in Unembalmed Human Cadaver Heads.
J Trauma.
1997;
42
705-710
- 13
Jin H, Thomas H F, Chen J.
Wound healing and revascularization: a histologic observation of experimental tooth
root fracture.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod.
1996;
81
26-30
- 14
Johnson K D, August A, Sciadini M F, Smith C.
Evaluation of ground cortical autograft as a bone graft material in a new canine bilateral
segmental long bone defect model.
J Orthop Trauma.
1996;
10
28-36
- 15
Kowalski M J, Schemitsch E H, Kregor P J, Senft D, Swiontkowski M F.
Effect of periosteal stripping on cortical bone perfusion: a laser doppler study in
sheep.
Calcif Tissue Int.
1996;
59
24-26
- 16
Lammens J, Liu Z, Aerssens J, Dequeker J, Fabry G.
Distraction bone healing versus osteotomy healing: a comparative biochemical analysis.
J Bone Miner Res.
1998;
13
279-286
- 17
Landry P S, Marino A A, Sadasivan K K, Albright J A.
Bone injury response. An animal model for testing theories of regulation.
Clin Orthop.
1996;
260-273
- 18
Lewandrowski K U, Tomford W W, Schomacker K T, Deutsch T F, Mankin H J.
Improved osteoinduction of cortical bone allografts: a study of the effects of laser
perforation and partial demineralization.
J Orthop Res.
1997;
15
748-756
- 19
Madsen J E, Hukkanen M, Aune A K, Basran I, Moller J F, Polak J M, Nordsletten L.
Fracture healing and callus innervation after peripheral nerve resection in rats.
Clin Orthop.
1998;
230-240
- 20
Newberry W N, Mackenzie C D, Haut R C.
Blunt impact causes changes in bone and cartilage in a regularly exercised animal
model.
J Orthop Res.
1998;
16
348-354
- 21
Pape H C, Grotz M, Remmers D, Dwenger A, Vaske R, Wisner D, Tscherne H.
Multiple organ failure (MOI) after severe trauma - a sheep model.
Intensive Care Med.
1998;
24
590-598
- 22 Park S H, O’Connor K, Sung R, McKellop H, Sarmiento A. Comparison of the Healing
Process in Open Osteotomy and Closed Fractures. Ulm; Anonymous 1999
- 23
Pasquale M D, Cipolle M D, Monaco J, Simon N.
Early inflammatory response correlates with the severity of injury.
Crit Care Med.
1996;
24
1238-1242
- 24
Probst A, Spiegel H U.
Cellular mechanisms of bone repair.
J Invest Surg.
1997;
10
77-86
- 25
Reynders P, Becker J, Broos P.
The osteogenic potential of free periosteal autografts in tibial fractures with severe
soft tissue damage: an experimental study.
Acta Orthop Belg.
1998;
64
184-192
- 26
Sakkers R J, Dalmeyer R A, Brand R, Rozing P M, van Blitterswijk C A.
Assessment of bioactivity for orthopedic coatings in a gap-healing model.
J Biomed Mater Res.
1997;
36
265-273
- 27
Samuelsson S M, Alfredson B B, Hagberg B, Samuelsson G, Nordbeck B, Brun A, Gustafson L,
Risberg J.
The Swedish Centenarian Study: a multidisciplinary study of five consecutive cohorts
at the age of 100.
Int J Aging Hum Dev.
1997;
45
223-253
- 28
Schemitsch E H, Turchin D C, Kowalski M J, Swiontkowski M F.
Quantitative assessment of bone injury and repair after reamed and unreamed locked
intramedullary nailing.
J Trauma.
1998;
45
250-255
- 29
Schemitsch E H, Kowalski M J, Swiontkowski M F.
Soft-tissue blood flow following reamed versus unreamed locked intramedullary nailing:
a fractured sheep tibia model.
Ann Plast Surg.
1996;
36
70-75
- 30
Schilling T, Muller M, Minne H W, Ziegler R.
Influence of inflammation-mediated osteopenia on the regional acceleratory phenomenon
and the systemic acceleratory phenomenon during healing of a bone defect in the rat.
Calcif Tissue Int.
1998;
63
160-166
- 31
Sciadini M F, Dawson J M, Johnson K D.
Evaluation of bovine-derived bone protein with a natural coral carrier as a bone-graft
substitute in a canine segmental defect model.
J Orthop Res.
1997;
15
844-857
- 32
Seibold R, Schlegel U, Cordey J.
A Technique for Production of Standard Spiral Fractures of the Tibia in Animal Experiments.
Unfallchirurg.
1995;
98
376-378
- 33
Seligson D, Mehta S, Mishra A K, FitzGerald T J, Castleman D W, James A H, Voor M J,
Been J, Nawab A.
In vivo study of stainless steel and Ti-13Nb-13Zr bone plates in a sheep model.
Clin Orthop.
1997;
213-223
- 34
Welch R D, Birch J G, Makarov M R, Samchukov M L.
Histomorphometry of distraction osteogenesis in a caprine tibial lengthening model
(see comments).
J Bone Miner Res.
1998;
13
1-9
- 35
Wolinsky P R, Banit D, Parker R E, Shyr Y, Snapper J R, Rutherford E J, Johnson K D.
Reamed intramedullary femoral nailing after induction of an „ARDS-like” state in sheep:
effect on clinically applicable markers of pulmonay function.
J Orthop Trauma.
1998;
12
169-175
- 36
Wolinsky P R, Sciadini M F, Parker R E, Plitman J D, Snapper J R, Rutherford E J,
Schulman M, Johnson K D.
Effects on pulmonary physiology of reamed femoral intramedullary nailing in an open-chest
sheep model.
J Orthop Trauma.
1996;
10
75-80
Dr. med. J. Schmidt
Klinik für Unfall-, Hand- und
Wiederherstellungschirurgie
am Klinikum Erfurt
Nordhäuser Straße 74
99089 Erfurt
