Semin Reprod Med 2001; 19(4): 323-330
DOI: 10.1055/s-2001-18640
Copyright © 2001 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

Emergency Contraception

Charlotte Ellertson1 , James Trussell2 , Felicia Stewart3 , Jacqueline Koenig4 , Elizabeth G. Raymond5 , Tara Shochet6
  • 1Director of Reproductive Health for Latin America and the Caribbean, The Population Council-Mexico, Col. Villa Coyoacan, México
  • 2Professor of Economics and Public Affairs, Associate Dean, Woodrow Wilson School of Public and International Affairs, and Faculty Associate, Office of Population Research, Wallace Hall, Princeton University, Princeton, New Jersey
  • 3Co-Director, Center for Reproductive Health Research & Policy, University of California, San Francisco, California
  • 4Assistant Director, Online Outreach and Partnerships, The Henry J. Kaiser Family Foundation, Menlo Park, California
  • 5Associate Medical Director, Biomedical Affairs Division, Family Health International, Research Triangle Park, North Carolina
  • 6Research Assistant, Office of Population Research, Wallace Hall, Princeton University, Princeton, New Jersey
Further Information

Publication History

Publication Date:
29 November 2001 (online)

ABSTRACT

Emergency contraceptives are methods that prevent pregnancy when used shortly after unprotected sex. Three different emergency contraceptive methods are safe, simple, and widely available in the United States. These are: (1) ordinary combined oral contraceptives containing ethinyl estradiol and levonorgestrel taken in a higher dose for a short period of time and started within a few days after unprotected intercourse; (2) levonorgestrel-only tablets used similarly; and (3) copper-bearing intrauterine devices inserted within approximately 1 week after unprotected intercourse. Emergency contraceptive use is best known for women who have been raped, but the methods are also appropriate for women who have experienced condom breaks, women who did not use any method because they were not planning on having sex, or women who had unprotected intercourse for any other reason. Unfortunately, few women know about emergency contraceptives, and few clinicians think to inform their patients routinely about the option. A nationwide toll-free hotline (1-888-NOT-2-LATE) and a website (http://not-2-late.com) can help women learn about these options. Sharing ``family planning's best-kept secret'' widely with women could prevent as many as a million unwanted pregnancies annually in the United States.

REFERENCES

  • 1 Henshaw S K. Unintended pregnancy in the United States.  Fam Plann Perspect . 1998;  30 24-46
  • 2 Trussell J, Stewart F, Guest F, Hatcher R A. Emergency contraceptive pills: a simple proposal to reduce unintended pregnancies.  Fam Plann Perspect . 1992;  24 269-273
  • 3 Abma J C, Chandra A, Mosher W D, Peterson L S, Piccinino L J. Fertility, family planning, and women's health: new data from the 1995 National Survey of Family Growth. Vital Health Stat 1997; Series 23, No. 19
  • 4 Van Look P F A, Stewart F. Emergency contraception. In: Hatcher RA, Trussell J, Stewart F, et al, eds. Contraceptive Technology 17th revised ed. New York: Ardent Media 1998: 277-295
  • 5 Glasier A. Emergency postcoital contraception.  N Engl J Med . 1997;  337 1058-1064
  • 6 Hatcher R A, Trussell J, Stewart F, Howells S, Russell C R, Kowal D. Emergency Contraception: The Nation's Best Kept Secret.  Decatur, GA: Bridging the Gap Communications; 1995
  • 7 Trussell J, Koenig J, Ellertson C, Stewart F. Preventing unintended pregnancy: the cost-effectiveness of three methods of emergency contraception.  Am J Public Health . 1997;  87 932-937
  • 8 Ellertson C, Webb A, Blanchard K. Three simplifications of the Yuzpe regimen of emergency contraception: results of a randomized, controlled trial in five centers.  Work in progress.
  • 9 Trussell J, Ellertson C, Stewart F. The effectiveness of the Yuzpe regimen of emergency contraception.  Fam Plann Perspect . 1996;  28 58-87
  • 10 Trussell J, Rodríguez G, Ellertson C. New estimates of the effectiveness of the Yuzpe regimen of emergency contraception.  Contraception . 1998;  57 363-369
  • 11 Trussell J, Rodríguez G, Ellertson C. Updated estimates of the effectiveness of the Yuzpe regimen of emergency contraception.  Contraception . 1999;  59 147-151
  • 12 Task Force on Postovulatory Methods of Fertility Regulation. Randomised controlled trial of levonorgestrel versus the Yuzpe regimen of combined oral contraceptives for emergency contraception.  Lancet . 1998;  352 428-433
  • 13 Piaggio G, von Hertzen H, Grimes D A, Van Look F A P. Timing of emergency contraception with levonorgestrel or the Yuzpe regimen.  Lancet . 1999;  353 721
  • 14 Grou F, Rodrigues I. The morning-after pill: how long after?.  Am J Obstet Gynecol . 1994;  171 1529-1534
  • 15 Sánchez-Borrego R, Balasch J. Ethinyl oestradiol plus dl*-norgestrel or levonorgestrel in the Yuzpe method for post-coital contraception: results of an observational study.  Hum Reprod . 1996;  11 2449-2453
  • 16 Raymond E G, Creinin M D, Barnhart K T, Lovvorn A E, Rountree W, Trussell J. Meclizine for prevention of nausea associated with emergency contraceptive pills: a randomized trial.  Obstet Gynecol . 2000;  95 271-277
  • 17 Improving access to quality care in family planning. Geneva: World Health Organization; 2000 . 
  • 18 Webb A. How safe is the Yuzpe method of emergency contraception?.  Fert Control Rev . 1995;  4 16-18
  • 19 Webb A, Taberner D. Clotting factors after emergency contraception.  Adv Contracept . 1993;  9 75-82
  • 20 Raman-Wilms L, Tseng A L, Wighardt S, Einarson T R, Koren G. Fetal genital effects of first-trimester sex hormone exposure: a meta-analysis.  Obstet Gynecol . 1995;  85 141-149
  • 21 Bracken M B. Oral contraception and congenital malformations in offspring: a review and meta-analysis of the prospective studies.  Obstet Gynecol . 1990;  76 552-557
  • 22 Simpson J L, Phillips O P. Spermicides, hormonal contraception and congenital malformations.  Adv Contracept . 1990;  6 141-167
  • 23 Food and Drug Administration. Prescription drug products: certain combined oral contraceptives for use as postcoital emergency contraception.  Federal Regist . 1997;  62 8610-8612
  • 24 Swahn M L, Westlund P, Johannisson E, Bygdeman M. Effect of post-coital contraceptive methods on the endometrium and the menstrual cycle.  Acta Obstet Gynecol Scand . 1996;  75 738-744
  • 25 Ling W Y, Robichaud A, Zayid I, Wrixon W, MacLeod S C. Mode of action of dl-norgestrel and ethinylestradiol combination in postcoital contraception.  Fertil Steril . 1979;  32 297-302
  • 26 Rowlands S, Kubba A A, Guillebaud J, Bounds W. A possible mechanism of action of danazol and an ethinylestradiol/ norgestrel combination used as postcoital contraceptive agents.  Contraception . 1986;  33 539-545
  • 27 Kubba A A, White J O, Guillebaud J, Elder M G. The biochemistry of human endometrium after two regimens of postcoital contraception: a dl-norgestrel/ethinylestradiol combination or danazol.  Fertil Steril . 1986;  45 512-516
  • 28 Ling W Y, Wrixon W, Zayid I, Acorn T, Popat R, Wilson E. Mode of action of dl-norgestrel and ethinylestradiol combination in postcoital contraception II: effect of postovulatory administration on ovarian function and endometrium.  Fertil Steril . 1983;  39 292-297
  • 29 Yuzpe A A, Thurlow H J, Ramzy I, Leyshon J I. Post coital contraception: a pilot study.  J Reprod Med . 1974;  13 53-58
  • 30 Taskin O, Brown R W, Young D C, Poindexter A N, Wiehle R D. High doses of oral contraceptives do not alter endometrial α1 and ανβ3 integrins in the late implantation window.  Fertil Steril . 1994;  61 850-855
  • 31 Raymond E G, Lovely L P, Chen-Mok M, Seppala M, Kurman R J, Lessey B A. Effect of the Yuzpe regimen of emergency contraception on markers of endometrial receptivity.  Hum Reprod . 2000;  15 2351-2355
  • 32 Ling W Y, Wrixon W, Acorn T, Wilson E, Collins J. Mode of action of dl-norgestrel and ethinylestradiol combination in postcoital contraception III: effect of preovulatory administration following the luteinizing hormone surge on ovarian steroidogenesis.  Fertil Steril . 1983;  40 631-636
  • 33 Trussell J, Raymond E G. Statistical evidence concerning the mechanism of action of the Yuzpe regimen of emergency contraception.  Obstet Gynecol . 1999;  93 872-876
  • 34 Protection of Human Subjects. OPRR Reports, Code of Federal Regulations 45CFR 46, March 8, 1983
  • 35 Hughes E C. Committee on Terminology, The American College of Obstetricians and Gynecologists, Obstetric-Gynecologic Terminology.  Philadelphia: F.A. Davis Company; 1972
  • 36 Statement on Contraceptive Methods. Washington DC: American College of Obstetricians and Gynecologists; July 1998
  • 37 Kennedy K I, Trussell J. Postpartum contraception and lactation. In: Hatcher RA, Trussell J, Stewart F, et al, eds. Contraceptive Technology 17th revised ed. New York: Ardent Media; 1998
  • 38 Trussell J, Ellertson C. Efficacy of emergency contraception.  Fert Control Rev . 1995;  4 8-11
  • 39 Farley T MM, Rosenberg M J, Rowe P J, Chen J-H, Meirik O. Intrauterine devices and pelvic inflammatory disease: an international perspective.  Lancet . 1992;  339 785-788
  • 40 Food and Drug Administration. Use of approved drugs for unlabeled indications.  FDA Drug Bull . 1982;  12 4-5
  • 41 Delbanco S F, Stewart F H, Koenig J D, Parker M L, Hoff T, McIntosh M. Are we making progress with emergency contraception: recent findings on American adults and health professionals.  J Am Med Wom Assoc . 1998 (suppl 2);  53 (242-246)
  • 42 Harper C, Ellertson C. The emergency contraceptive pill: a survey of knowledge and attitudes among students at Princeton University.  Am J Obstet Gynecol . 1995;  173 1438-1445
  • 43 Glasier A, Baird D. The effects of self-administering emergency contraception.  N Engl J Med . 1998;  339 1-4
  • 44 Kosunen E, Sihvo S, Hemminki E. Knowledge and use of hormonal emergency contraception in Finland.  Contraception . 1997;  55 153-157
  • 45 Raine T, Harper C, Leon K, Darney P. Emergency contraception: advance provision in a young, high-risk clinic population.  Obstet Gynecol . 2000;  96 1-7
  • 46 Trussell J, Bull J, Koenig J, Bass M, Allina A, Gamble V N. Call 1-888-NOT-2-LATE: promoting emergency contraception in the United States.  J Am Med Wom Assoc . 1998 (suppl 2);  53 (247-250)
  • 47 Ellertson C, Trussell J, Stewart F, Winikoff B. Should emergency contraceptive pills be available without prescription?.  J Am Med Wom Assoc . 1998 (suppl 2);  53 (226-232)
  • 48 American College of Obstetricians and Gynecologists press release, 14 February 2001. Available at: http://www.acog.org/ from_home/publications/press_releases/nr02-14-01.htm. Accessed February 14, 2001
  • 49 Center for Reproductive Law and Policy press release, 14 February 2001. Available at: http://www.crlp.org/ pr_01_214 ecpetition.html. Accessed February 14, 2001
  • 50 ``Groups push for over-the-counter emergency contraceptive pill,'' Associated Press, 13 February 2001. Available at: http://www.msnbc.com/news/530547.asp?cp1=1. Accessed February 14, 2001
  • 51 Wells E S, Hutchings J, Gardiner J S. Using pharmacies in Washington State to expand access to emergency contraception.  Fam Plann Perspect . 1998;  30 288-290
  • 52 The Henry J. Kaiser Family Foundation. Kaiser Daily Reproductive Health Report. Available at: http://report.kff.org/archive/repro/2001/1/kr010126.6.htm. Accessed February 14, 2001
  • 53 The Henry J. Kaiser Family Foundation. Available at: http://www.kff.org/content/2000/20001115a/. Accessed February 15, 2001
  • 54 Emergency Oral Contraception. ACOG Practice Patterns.  No. 3. Washington DC: The American College of Obstetricians and Gynecologists; December 1996
  • 55 Emergency Contraceptive Pills: Common Legal Questions about Prescribing, Dispensing, Repackaging, and Advertising. New York: The Center for Reproductive Law and Policy; 1999
  • 56 Wells E, Crook B, Muller N. Emergency Contraception: Resources for Providers.  Seattle, WA: Program for Appropriate Technology in Health; 1997
  • 57 Emergency Contraception: Client Materials for Diverse Audiences. Seattle, WA: Program for Appropriate Technology in Health; 1998
  • 58 Trussell J, Leveque J A, Koenig J D. The economic value of contraception: a comparison of 15 methods.  Am J Public Health . 1995;  85 494-503
  • 59 Trussell J, Koenig J, Stewart F, Darroch J E. Medical care cost savings from adolescent contraceptive use.  Fam Plann Perspect . 1997;  29 248-295
  • 60 Brown S S, Eisenberg L. The Best Intentions: Unintended Pregnancy and the Well-Being of Children and Families.  Washington, DC: National Academy Press; 1995
  • 61 Ellertson C, Koenig J, Trussell J, Bull J. How many U.S. women need emergency contraception?.  Contemp Ob Gyn . 1997;  42 102-128
    >