Abstract
In a photochemical reaction microvessel thrombosis model, the anti-thrombotic effect of PT was evaluated and the results showed that PF could significantly prolong thromobosis time. The anti-thrombotic effect of PF may relate to the inhibition of arachidonic acid metabolism, the increase of t-PA activity, and the protective effect against free radical.
Abbreviations
PF:paeoniflorin
t-PA:tissue-type plasminogen activator
PAI:plasminogen activator inhibitor
HUVEC:human umbilical vein endothelial cell
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Prof. Xiaoxiang Zheng
Department of Biomedical Engineering
Zhejiang University
Hangzhou
P.R. China 310027
Email: zxx@mail.hz.zj.cn
Fax: 086-571-87951676
