Abstract
The efficacy of a series of aurones, auronols and 4-methoxy-α-pyrones has been screened
for the ability to inhibit the intracellular growth of the parasitic protist Cryptosporidium parvum using an in vitro enzyme linked immunosorbent assay (ELISA). All aurones of this series were active
at 25 to 100 μM. 10 of 19 aurones inhibited the intracellular growth of C. parvum by > 90 % with moderate to no toxicity. The most active of these was 3′,4′,6-trihydroxy-2-[phenylmethylene]-3(2H)-benzofuranone.
Key words
Aurones -
Cryptosporidium
- ELISA assay - protist chemotherapy - drug testing
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Dr. Oliver Kayser
Freie Universität Berlin
Institut für Pharmazie
Pharmazeutische Biotechnologie
Kelchstraße 31
12169 Berlin
Germany
Email: kayser@zedat.fu-berlin.de
Fax: +49-30-838 50605
Phone: Tel.: +49-30-838 50689
