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Semin Reprod Med 2001; 19(1): 097-102
DOI: 10.1055/s-2001-13916
Copyright © 2001 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

A New Function for the LH/CG Receptor: Transcytosis of Hormone Across the Endothelial Barrier in Target Organs

Nicolae Ghinea, Edwin Milgrom
  • INSERM U-135, Hormones, Gènes, et Reproduction, Hôpital de Bicêtre, Le Kremlin-Bicêtre, France
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Publication History

Publication Date:
31 December 2001 (online)

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ABSTRACT

Gonadotropins cross the vascular endothelial barrier to reach their target organs. Hormone concentrations in blood are very low and fluctuate rapidly to give sharp biological effects. Nonspecific transendothelial transport mechanisms are slow and markedly concentration dependent. There is thus a need for specific transendothelial transport mechanisms for these hormones. We will describe a specific transcytosis mechanism involving endothelial lutropin/chorionic gonadotropin (LH/CG) receptors identical to those observed in the target Leydig cells. A new role for the LH/CG receptor as a transcytotic carrier of its ligands in endothelial cells is suggested.

KEYWORD

LH/CG receptor - endothelial cells - receptor-mediated transcytosis - lutropin - protein hormones

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