An investigation was made to evaluate the role of Convolvulus pluricaulis root extract in the regulation of hyperthyroidism in female mice. Its possible site
of action was also studied. L-Thyroxine treatment for 30 days increased serum concentrations
of thyroxine (T4) and triodothyronine (T3). The activity of hepatic 5’-monodeiodinase (5’-DI) and glucose-6-phosphatase (G-6-Pase)
was also enhanced. On the other hand, administration of the plant extract either alone
or with L-T4, decreased serum T3 concentration and the activity of hepatic 5’-DI and G-6-phase, without marked alteration
in hepatic lipid peroxidation, indicating the possible regulation of hyperthyroidism
by the plant extract. It appears that the action of the plant extract on thyroid function
is primarily mediated through the inhibition of 5’-DI enzyme activity.
Key words:
L-Thyroxine - Convolvulus pluricaulis - Triodothyronine - 5’-Monodeiodinase - Lipid peroxidation - Glucose-6-phosphatase
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Dr. A Kar
Thyroid Research Unit, School of Life Sciences
Devi Ahilya University,
Khandwa Road
Indore-452017
India
Phone: Phone:+ 0091 (731) 467029
Fax: Fax:+ 0091 (731) 472793
