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Planta Med 2000; 66(8): 709-713
DOI: 10.1055/s-2000-9907
Original Paper
Georg Thieme Verlag Stuttgart · New York

Hepatocurative Effect of Picroliv and Silymarin Against Aflatoxin B1 Induced Hepatotoxicity in Rats1 []

Ravi Rastogi1 , Arvind Kumar Srivastava1,*, Mukesh Srivastava2 , Anil Kumar Rastogi1
  • 1 Division of Biochemistry, CDRI, Lucknow
  • 2 Division of Biometry & Statistics, CDRI, Lucknow
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Publication History

Publication Date:
31 December 2000 (online)

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Abstract

Single doses of aflatoxin B1 (2 mg/kg, i.p.) caused significant increases in the activities of τ-glutamyl transpeptidase, 5′-nucleotidase, acid phosphatase and acid ribonuclease, and decreases in the activities of succinate dehydrogenase and glucose-6-phosphatase in liver, after 8 weeks. The level of lipid peroxides, DNA, RNA, and cholesterol increased while glycogen decreased. It also increased the serum level of transaminases, sorbitol dehydrogenase, glutamate dehydrogenase, lactate dehydrogenase, acid phosphatase, alkaline phosphatase, and bilirubin. Oral administration of picroliv (25 mg/kg/day for 15 days), a standardised iridoid glycoside fraction of Picrorhiza kurroa, 6 weeks after aflatoxin B1 toxication, significantly prevented the biochemical changes induced in liver and serum of aflatoxin B1 treated rats. The hepatocurative effect of picroliv and silymarin, a plant based standard hepatoprotective are comparable.

Key words

Picrorhiza kurroa - Scrophulariaceae - silymarin - hepatotoxicity - hepatoprotection - aflatoxin-B1 - picroliv

1 CDRI Communication No. 5982

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1 CDRI Communication No. 5982

Dr. A. K. Srivastava

Biochemistry Division Central Drug Research Institute

226001 Lucknow

India