Fungal Meningitis

Magnús Gottfredsson; John R. Perfect

doi:10.1055/s-2000-9394

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Semin Neurol 2000; Volume 20(Number 03): 307-322
DOI: 10.1055/s-2000-9394

Fungal Meningitis

Magnús Gottfredsson^1,2 , John R. Perfect²

¹Department of Medicine, Infectious Diseases Section, Landspitalinn, National University Hospital, Reykjavik Iceland
²Department of Medicine, Division of Infectious Diseases and International Health, Duke University Medical Center, Durham, North Carolina

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Publication History

Publication Date:
31 December 2000 (online)

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ABSTRACT

Fungi provide many benefits to humans. However, some of these fungi have the ability to become human pathogens. All the major fungal pathogens can produce meningitis. From the common cryptococcal meningitis to the rare fungal meningitis caused by a dimorphic or filamentous fungus, medical issues are discussed in this review on a fungus-specific basis. Both primary (Cryptococcus, Blastomyces, Histoplasma, Coccidioides, and other dimorphic fungi) and secondary (Aspergillus, Candida, and a series of molds) fungal pathogens can produce life-threatening central nervous system infections. These infections require immediate and precise diagnosis and carefully selected management strategies to optimize outcomes. In this review, we examine the epidemiology, pathogenesis, clinical manifestations, and treatment for fungal meningitis in all the major fungal groups.

KEYWORD

Meningitis - fungi - central nervous system infections

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