Download PDF
Planta Med 2000; 66(7): 627-629
DOI: 10.1055/s-2000-8629
Original Paper
Georg Thieme Verlag Stuttgart · New York

Cardioactive Terpenoids and a New Rearranged Diterpene from Salvia syriaca

Ayhan Ulubelen1,*, Sevil Öksüz1 , Ufuk Kolak1 , Hüsniye Birman2 , Wolfgang Voelter3
  • 1 University of Istanbul, Faculty of Pharmacy, Department of Chemistry, Istanbul, Turkey
  • 2 University of Istanbul, Faculty of Medicine, Department of Physiology, Istanbul, Turkey
  • 3 Abteilung für Physikalische Biochemie des Physiologisch-chemischen Instituts, Universität Tübingen, Tübingen, Germany
Further Information

Publication History

Publication Date:
31 December 2000 (online)

    Permissions and Reprints

Abstract

From the roots of Salvia syriaca L., in addition to known terpenoids, a new rearranged diterpene, named salvisyrianone, was isolated. The structure of the new compound was assigned from spectral data. The crude extract and the single compounds were tested for cardiovascular parameters using Wistar Albino rats. Antihypertensive activity was established in the crude extract of the roots as well as in two compounds, ferruginol and 3β-hydroxystigmast-5-en-7-one.

References

  • 1 Baytop  T.. Theraphy with Medicinal Plants of Turkey,. Univ. of Istanbul Pub., No. 3255, Istanbul:; 1984: 156-8
  • 2 Ulubelen  A,, Topcu  G.. Studies in Natural Products Chemistry,. Vol. 20, 1998: 659-718
  • 3 Rustaiyan  A,, Sadjadi  A.. Salvisyriacolide, a sesterterpene from Salvia syriaca. .  Phytochemistry. 1987;;  26 3078-9
    CrossrefPubMedGoogle Scholar
  • 4 Hatam  N AR,, Yousif  N J.. Flavonoids from Salvia syriaca. .  Int. J. Pharmacogn.. 1992;;  30 109-11
    PubMedGoogle Scholar
  • 5 Cambie  R C,, Madden  R J,, Parnell  J C.. Chemistry of Podocarpaceae XXVIII Constituents of some Podocarpus and other species.  Aust. J. Chem.. 1971;;  24 217-21
    PubMedGoogle Scholar
  • 6 Topçu  G,, Eriş  C,, Ulubelen  A.. Rearranged abietane diterpenes from Salvia limbata.  Phytochemistry. 1996;;  41 1143-7
    CrossrefPubMedGoogle Scholar
  • 7 Ulubelen  A,, Öksüz  S,, Kolak  U,, Bozok-Johansson  C,, Çelik  C,, Voelter  W.. Antibacterial Diterpenes from the roots of Salvia viridis. .  Planta Medica. 2000;;  66 458-62
    Article in Thieme ConnectPubMedGoogle Scholar
  • 8 Ulubelen  A,, Topçu  G,, Tan  N.. Diterpenoids from Salvia candidissima. .  Tetrahedron Lett.. 1992;;  33 7241-4
    CrossrefPubMedGoogle Scholar
  • 9 Karrer  W.. Konstitution und Vorkommen der Organischen Pflanzenstoffe,. Birkhäuser, Basel and Stuttgart,; 1958: p. 855
  • 10 Greca  M D,, Monaco  P,, Previtera  L.. Stigmasterols from Typha latifolia. .  J. Nat. Prod.. 1990;;  53 1430-5
    CrossrefPubMedGoogle Scholar
  • 11 Boiteau  P,, Pasich  B,, Ratsimamanga  A R.. Les Triterpenoids,. Gauthier-Villards, Paris,; 1964: p. 139-184
  • 12 Ulubelen  A,, Öztürk  S,, Işldatıcı  S.. A New Flavone from Salvia triloba L.  J. Pharm. Sci.. 1968;;  57 1037-8
    PubMedGoogle Scholar
  • 13 Williams  G H.. Harrison's Principles of Internal Medicine, 14th edition,. Vol. 1, 1998: 1392-4
  • 14 Abdalla  S,, Abu-Zarga  M,, Sabri  M.. Effects of the flavone luteolin, isolated from Colchicum richii, on guinea-pig isolated smooth muscle and heart and on blood pressure and blood flow.  Phytother. Res.. 1994;;  8 265-70
    PubMedGoogle Scholar

Prof. Dr. Ayhan Ulubelen

Department of Chemistry Faculty of Pharmacy University of Istanbul

34452 Istanbul

Turkey

Phone: +90 212 5193086

      >