Planta Med 2000; 66(3): 273-274
DOI: 10.1055/s-2000-8569
Letter
Georg Thieme Verlag Stuttgart · New York

α-Glycosidase Inhibitory Activity of Hexagalloylglucose from the Galls of Quercus infectoria

Jae-Kwan Hwang1,*, Tae-Wook Kong1 , Nam-In Baek2 , Yu-Ryang Pyun1
  • 1 Dept. of Biomaterials Science and Engineering & Bioproducts Research Center, Yonsei University, Seoul, Korea
  • 2 Dept. of Life Science, Kyunghee University, Seoul, Korea
Further Information

Publication History

Publication Date:
31 December 2000 (online)

Abstract

Hexagalloylglucose (3-O-digalloyl-1,2,4,6-tetra-O-galloyl-β-D-glucose), which was isolated from the methanol extract of the galls of Quercus infectoria, significantly inhibited α-glycosidases such as sucrase, maltase and isomaltase. Its inhibitory activity was comparable to acarbose being used as a hypoglycemic agent, while the inhibitory activity on α-amylase was approximately 10 times lower than that of acarbose. The results indicate that, when compared to acarbose, hexagalloylglucose might reduce the side effects by reducing inhibition of α-amylase.

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Ph.D. Jae-Kwan Hwang

Bioproducts Research Center Yonsei University

134 Shinchon-dong, Sudaemoon-ku

Seoul 120-749

Korea

Email: jkhwang@yonsei.ac.kr

Phone: +82-2-312-6821