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Planta Med 2000; 66(3): 251-256
DOI: 10.1055/s-2000-8562
Original Paper
Georg Thieme Verlag Stuttgart · New York

Anti-Platelet Aggregation Alkaloids and Lignans from Hernandia nymphaeifolia

Jih-Jung Chen1 , Ya-Ling Chang2 , Che-Ming Teng2 , Ih-Sheng Chen3,*
  • 1 Department of Pharmacy, Tajen Institute of Technology, Pingtung, Taiwan, Republic of China
  • 2 Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of China
  • 3 Graduate Institute of Pharmaceutical Sciences, Kaohsiung Medical College, Kaohsiung, Taiwan, Republic of China
Further Information

Publication History

Publication Date:
31 December 2000 (online)

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Abstract

A new aporphine, N-(N-methylcarbamoyl)-O-methylbulbocapnine (1), together with seven known compounds, (-)-5′-methoxypodorhizol (2), a mixture of β-sitosterone (3) and stigmasta-4,22-dien-3-one (4), a mixture of 3β-hydroxystigmast-5-en-7-one (5) and 3β-hydroxystigmasta-5,22-dien-7-one (6), and a mixture of 6α-hydroxystigmast-4-en-3-one (7) and 6α-hydroxystigmasta-4,22-dien-3-one (8), were isolated in continuing studies on the trunk bark of Formosan Hernandia nymphaeifolia. The structures of these compounds were determined through spectral analyses. In addition, the previously reported six alkaloids, laurotetanine, oxohernagine, thalicarpine, reticuline, (+)-vateamine-2′-β-N-oxide, (+)-hernandaline and six lignans, (+)-epiaschantin, (+)-epimagnolin, (+)-epiyangambin, (-)-hernone, (-)-yatein, (-)-deoxypodophyllotoxin were demonstrated to have anti-platelet aggregation activity.

Key words

Hernandia nymphaeifolia - Hernandiaceae - bark - aporphine alkaloids - lignans - N-(N-methylcarbamoyl)-O-methylbulbocapnine - anti-platelet aggregation activity

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Prof. Dr. I. S. Chen

Graduate Institute of Pharmaceutical Sciences Kaohsiung Medical College

Kaohsiung

Taiwan

Republic of China

Email: m635013@cc.kmc.edu.tw

Phone: +886-7-3210683

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