Assessment of Antimycobacterial Activity of a Series of Mainly Marine Derived Natural Products

Abstract

A series of mainly marine derived natural products were tested for their activities against Mycobacterium tuberculosis and M. avium. Of the thirty-nine compounds tested fifteen demonstrated minimum inhibition concentrations (MICs) of 32 μg/ml or less, and eleven had MICs of 16 μg/ml or less. The most active compound found in this study was the sponge derived metabolite axisonitrile-3 (MIC 2 μg/ml).

Key words

Marine natural products - Mycobacterium tuberculosis - Mycobacterium avium - biological testing - tuberculosis

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