Homocysteine and Venous Thrombosis: Outline of a Vitamin Intervention Trial

H. U. U. B. P. J. WILLEMS; M. A. R. T. I. N. DEN HEIJER; G. E. R. A. R. D. M. J. BOS

doi:10.1055/s-2000-8097

Seminars in Thrombosis and Hemostasis, Table of Contents

Semin Thromb Hemost 2000; Volume 26(Number 03): 297-304
DOI: 10.1055/s-2000-8097

Homocysteine and Venous Thrombosis: Outline of a Vitamin Intervention Trial

HUUB. P.J. WILLEMS¹ , MARTIN. DEN HEIJER² , GERARD. M.J. BOS³

¹Department of Haematology, Leyenburg Hospital, The Hague
²Department of Internal Medicine, Academical Hospital, Nijmegen
³Department of Internal Medicine, Academical Hospital, Maastricht, The Netherlands

Abstract

ABSTRACT

In the past years several case-control studies established the association of an elevated plasma homocysteine concentration and the risk of venous thromboembolism. It is still unclear if elevated homocysteine concentrations can cause venous thrombosis. The VITRO (VItamins and ThROmbosis) trial is the first multicenter, randomized, double-blind and placebo-controlled study to evaluate the effect of homocysteine-lowering therapy by means of 5 mg folic acid, 0.4 mg vitamin B₁₂ and 50 mg vitamin B₆. The study is a secondary prevention trial in 600 patients who suffered from a first episode of idiopathic deep vein thrombosis (DVT) or pulmonary embolism (PE), or both. There will be 300 hyperhomocysteinemic and 300 normohomocysteinemic patients included, all with an objectivated venous thrombosis. The end point is recurrence of venous thrombosis.

KEYWORD

Homocysteine - hyperhomocysteinemia - venous thrombosis - vitamin treatment - multicenter trial

Full Text

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