To assess the eventual effects of acute oral salbutamol intake on performance and
metabolism during submaximal exercise, nine healthy volunteers completed two cycling
trials at a power corresponding to 80 - 85 % V˙O2max, after either placebo (Pla) or salbutamol (Sal, 6 mg) treatment, according to
a double-blind randomized protocol. Blood samples were collected both at rest and
during exercise (5 min-, 10 min-, 15 min-exhaustion) for C-peptide, FFA, lactate and
blood glucose measurements. Cycling performance was significantly improved in the
Sal vs. Pla trials (p < 0.05). After Sal intake, resting C-peptide, lactate, FFA and
blood glucose values were higher whereas exercise lactate and free fatty acid concentrations
were greater during and at the conclusion of the exercise period (p < 0.05). These
results suggest that acute salbutamol ingestion improved performance during submaximal
exercise probably through an enhancement of the overall contribution to energy production
from both aerobic and anaerobic metabolisms.
Key words:
β2-adrenoceptor agonist, oral intake, performance, lactate, free fatty acids.
References
- 1
Bedi J, Gong H, Horvath S.
Enhancement of exercise performance with inhaled albuterol.
Can J Sport Sci.
1988;
13
144-148
- 2
Dill D, Costill D.
Calculation of percentage changes in volume of blood, plasma, and red blood cells
in dehydratation.
J Appl Physiol.
1974;
37
247-248
- 3
Fleck S, Lucia A, Storms W, Wallach J, Vint P, Zimmerman S.
Effects of acute inhalation of albuterol on submaximal and maximal V˙O2 and blood lactate.
Int J Sports Med.
1993;
14
239-243
- 4
Freeman W, Packe G, Cayton R.
Effect of nebulised salbutamol on maximal exercise performance in men with mild asthma.
Thorax.
1989;
44
942-947
- 5
Granier P, Mercier B, Mercier J, Anselme F, Préfaut C.
Aerobic and anaerobic contribution to Wingate test performance in sprint and middle-distance
runners.
Eur J Appl Physiol.
1995;
70
58-65
- 6
Hopkins W, Hawley J, Burke L.
Design and analysis of research on sport performance enhancement.
Med Sci Sports Exerc.
1999;
31
472-485
- 7 International Olympic Committee .List of doping classes and methods. 1999
- 8
Issekutz B, Paul P, Miller H, Bortz M.
Oxidation of plasma FFA in lean and obese humans.
Metabolism.
1968;
17
62-68
- 9
Katz A, Sahlin K, Juhlin-Dannfelt A.
Effect of β-adrenoceptor blockade on H+ and K+ flux in exercising humans.
J Appl Physiol.
1985;
59
336-341
- 10
Larsson K, Gavhed D, Larsson L, Holmer I, Jorfelt L, Ohlsen P.
Influence of a β2-agonist on physical performance at low temperature in elite athletes.
Med Sci Sports Exerc.
1997;
29
1631-1636
- 11
McKenzie S, Rhodes E, Stirling D, Wiley J, Dunwoody D, Filsinger I.
Salbutamol and treadmill performance in non-atopic athletes.
Med Sci Sports Exerc.
1983;
15
520-522
- 12
Meeuwisse W, McKenzie D, Hopkins S, Road J.
The effect of salbutamol on performance in elite nonasthmatic athletes.
Med Sci Sports Exerc.
1992;
24
1161-1166
- 13
Morton A, Palpea S, Fitch K.
Is salbutamol ergogenic? The effects of salbutamol on physical performance in high-performance
nonasthmatic athletes.
Clin J Sport Med.
1992;
2
93-97
- 14
Price A, Clissold S.
Salbutamol in the 1980s. A reappraisal of its clinical efficacy.
Drugs.
1989;
38
77-122
- 15
Richter E, Ruderman N, Gavras H, Belur E, Galbo H.
Muscle glycogenolysis during exercise: dual control by epinephrine and contractions.
Am J Physiol.
1982;
242
E25-E32
- 16
Rolf Smith S, Kendall M.
Metabolic responses to β2 stimulants.
J R Coll Chest Physiol.
1984;
18
190-194
- 17
Smith A, Banks J, Buchenen K, Cheong B, Gunawardena K.
Mechanisms of abnormal glucose metabolism during the treatment of acute severe asthma.
Q J Med.
1992;
82
71-80
- 18
Voy R.
The U.S. Olympic Committee experience with exercise-induced bronchospasm, 1984.
Med Sci Sports Exerc.
1986;
18
328-330
- 19
Wager J, Fredholm B, Lunell N, Persson B.
Metabolic and circulatory effects of intravenous and oral salbutamol in late pregnancy
in diabetic and non diabetic women.
Acta Obstet Gynaecol Scand.
1982;
108
41-46
- 20
Weiler J, Layton M, Hunt M.
Asthma in United States Olympic athletes who participated in the 1996 Summer Games.
J Allergy Clin Immunol.
1998;
102
722-726
- 21
Whyte K, Addis G, Whitesmith R, Reid J.
The mechanism of salbutamol-induced hypokalaemia.
Br J Clin Pharm.
1987;
23
65-71
Katia Collomp
Laboratoire National de Dépistage du Dopage CREPS
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