Zusammenfassung
Kaum ein Vorgehen ist sowenig standardisiert wie das Vorgehen beim
vorzeitigen Blasensprung am Termin (PROM). Nach unseren Vorstellungen sollte
daher das eigene Management immer wieder anhand eigener Daten
überprüft und ggf. modifiziert werden. Zur Feststellung des
Ist-Zustands haben wir über drei Monate 400 Schwangerschaften retrospektiv
analysiert. Die Patientinnen mit vorzeitigem Blasensprung am Termin
(> 36 + 0 SSW) wurden zunächst 24 h
lang abwartend beobachtet und dann bei Fehlen eigener Wehen abhängig vom
Zervixbefund eingeleitet. Sie wurden hinsichtlich Parität, Zervixbefund
bei Aufnahme, Anzahl der vaginalen Untersuchungen, Geburtsmodus,
Amnioninfektionssyndrom und Neugeboreneninfektion aufgeschlüsselt. Ein
vorzeitiger Blasensprung fand sich in 10 %. Erstgebärende
waren mit 73 % überdurchschnittlich häufig vertreten.
Erwartungsgemäß fand sich bei 73 % ein unreifer
Muttermundbefund. Das Intervall zwischen Blasensprung und Geburt betrug im
Mittel 27 h. Die Hälfte der Kinder kam erst 24 h nach PROM
zur Welt. Lag der Blasensprung länger als 24 h zurück, so
verdoppelte sich die Rate der Kaiserschnitte (15 vs. 30 %), die
Rate der vaginal-operativen Entbindungen (11 vs. 20 %), die
Anzahl der Amnioninfektionssyndrome (16 vs. 35 %) und die
Verlegung auf die Neugeborenenintensivstation (16 vs. 25 %). Bis
zur Geburt wurden die Patientinnen vergleichsweise häufig vaginal
untersucht (bis zu 18-mal; im Mittel 8-mal). Aufgrund der dargelegten Resultate
halten wir ein aktiveres Vorgehen 6 - 8 h nach
Blasensprung und Ausbleiben eigener regelmäßiger Wehentätigkeit
für indiziert. Insbesondere Erstgebärende mit unreifer Zervix
können davon profitieren. Die Häufigkeit vaginaler Untersuchungen
sollte reduziert werden.
Few procedures are less standardised than the procedure in case of
prelabour rupture of the membranes at term (PROM). We propose that management
should be reviewed regularly on the basis of one's own data and be modified
accordingly if necessary. For the duration of three months we analysed 400
pregnancies retrospectively. Patients with PROM were observed expectantly for
24 hours. If there were no spontaneous uterine contractions, labour was
induced, depending on the degree of cervical dilatation. 10 percent of the
cases studied had PROM. Of these a high proportion of 73 percent were
primigravida, likewise 73 percent had an unripe cervix. The average time
between PROM and delivery was 27 h. 50 percent of the babys were born
24 h after PROM. If delivery occurred more than 24 h after PROM,
the rate of caesarean section (15 vs. 30 percent), the rate of forceps
deliveries (11 vs. 20 percent), the rate of amnionitis (16 vs. 35 percent) and
the number of admissions to the newborn-ICU (16 vs. 25 percent) almost doubled.
The patients were examined vaginally relatively often prior to delivery (up to
18 times, with a mean of 8 times). We therefore recommend active management
6 - 8 h after PROM, should there be no onset of
spontaneous uterine contractions. This is particularly beneficial to
primigravida with an unripe cervix.
Schlüsselwörter
vorzeitiger Blasensprung am Termin - Geburtseinleitung - Erstgebärende - unreife Zervix
Key words
Prelabor rupture of the membranes at term - induction of labor - nulliparous women
- unripe cervix
Literatur
- 01
Lewis
D F, Major
C A, Towers C V et
al.
Effects of digital vaginal examinations on latency period in
term rupture of membranes.
Obstet Gynecol.
1992;;
80
630-634
- 02
Meikle
S F, Bissell
M E, Freedman W L et
al.
A retrospective review of the efficacy and safety of
prostaglandin E2 with premature rupture of the membranes at term.
Obstet Gynecol.
1992;;
80
76-79
- 03
Cunn
G C, Mishell
D R, Morton
D G.
Premature rupture of fetal membranes: a review.
Am J Obstet Gynecol.
1970;;
106
469-483
- 04
Duff P, Huff
R W, Gibbs R S.
Management of premature rupture of the membranes and
unfavorable cervix in term pregnancy.
Obstet Gynecol.
1984;;
63
697-702
- 05
Kappy
K A, Cetrulo
C L, Knuppel R A et
al.
Premature rupture of membranes: a conservative approach.
Am J Obstet Gynecol.
1979;;
134
655-661
- 06
Martius J, Krohn
M A, Hillier
S L, Stamm W E et
al.
Relationship of vaginal lactobacillus species, cervical
chlamydia trachomatis and bacterial vaginosis to preterm birth.
Obstet Gynecol.
1988;;
71
89-95
- 07
Miller
J M, Pupkin
M J, Hill G B.
Bacterial colonization from amniotic fluid with intact fetal
membranes.
Am J Obstet Gynecol.
11980;;
36
796-804
- 08
Toth M, Witkin
S S, Ledger W et al.
The role of infection in the etiology of preterm birth.
Obstet Gynecol.
1988;;
71
723-726
- 09
Romen Y, Greenspoon
J, Artal R.
Clinical chorioamnionitis: analysis of the incubation period
in patients with preterm premature rupture of the membranes.
Am J Perinatol.
1985;;
2
314-316
- 10
Romero R, Hobbins
J C, Mitchell
M D.
Endoxin stimulates prostaglandin E2 production by human
amnion.
Obstet Gynecol.
1988;;
71
227-228
- 11
Romero R, Brody
D T, Oyarzum E et al.
Infection and labor, III: interleukin-1: a signal for the
onset of parturition.
Am J Obstet Gynecol.
1989;;
160
1117-1123
- 12
Calkins L A.
Premature spontaneous rupture of the membranes.
Am J Obstet Gynecol.
1952;;
16
5
- 13
Shubeck F, Benson
R C, Clark W W et
al.
Fetal hazard after rupture of the membranes.
Obstet Gynecol.
1966;;
28
22
- 14
Lanier
L R, Scarbrough
R W, Fillingim
D W, Baker R E.
Prudence of maternal and fetal complications associated with
rupture of the membranes before onset of labor.
Am J Obstet Gynecol.
1965;;
93
398-404
- 15
Russell
K P, Anderson
G V.
The aggressive management of ruptured membranes.
Am J Obstet Gynecol.
1962;;
83
930-937
- 16
Webb G A.
Maternal death associated with premature rupture of the
membranes.
Am J Obstet Gynecol.
1967;;
98
594
- 17
Calkins L A.
Premature spontaneous rupture of the membranes.
Am J Obstet Gynecol.
1952;;
64
871-877
- 18
Wagner
M V, Chin
V P, Peters C J et
al.
A comparison of early and delayed induction of labor with
spontaneous rupture of membranes at term.
Obstet Gynecol.
1989;;
74
93-97
- 19
Rhydström
H, Ingemarsson I.
No benefit from conservative management in nulliparous women
with premature rupture of the membranes (PROM) at term: a randomized
study.
Acta Obstet Gynecol Scand.
1991;;
70
543-547
- 20
Rhydström
H, Arulkumaran S, Ingemarsson
I et al.
Premature rupture of the membranes at term: obstetric outcome
with oxytocin stimulation in relation to parity and cervical dilation at
admission.
Acta Obstet Scand.
1986;;
65
587-591
- 21
Kappy
K A, Cetrulo
C L, Knuppel
R A.
Premature rupture of the membranes at term.
J Reprod Med.
1982;;
27
29-33
- 22
Conway
D I, Prendiville
W J, Morris A et al.
Management of spontaneous rupture of the membranes in the
abscence of labor in primigravid women at term.
Am J Obstet Gynecol.
1984;;
150
947-951
- 23
Grant
J M, Serle E, Mahmood
T et al.
Management of prelabor rupture of the membranes in term
primigravidae: a report of a randomized prospective trial.
Br J Obstet Gynaecol.
1992;;
99
557-562
- 24
Hannah
M E, Ohlsson
A, Farine D et al.
Induction of labor compared with expectant management for
prelabor rupture of the membranes at term.
N Engl J Med.
1996;;
334
1005-1010
- 25
Chua S, Arulkumaran
S, Yap C et al.
Premature rupture of the membranes in Nulliparae at term with
unfavorable cervices: a double-blind randomized control of prostaglandin and
placebo.
Obstet Gynecol.
1995;;
86
550-554
- 26
Sperling
L S, Schantz
A L, Wählin A et
al.
Management of prelabour rupture of membranes at term. A
Randomized study.
Acta Obstet et Gynecol Scand.
1993;;
72
627-632
- 27
Garite
T J, Freeman
R K, Linzey E M et
al.
Prospective randomized study of corticoids in the management
of premature rupture of the membranes and the premature gestation.
Am J Obstet Gynecol.
1981;;
141
508
- 28
Cammu H, Verlaenen
H, Derde M P.
Premature rupture of membranes at term in nulliparous women:
a hazard?.
Obstet Gynecol.
1990;;
76
671-674
- 29
Garite T J.
Premature rupture of the membranes: the enigma of the
obstetrician.
Am J Obstet Gynecol.
1985;;
151
1001-1005
- 30
Lettau R, Hege
G, Steldinger R.
Vorzeitiger Blasensprung am Termin: Eine Indikation zur
Geburtseinleitung mit Protaglandinen?.
Zentralblatt für Gynäkologie.
1995;;
117
121-125
- 31
Tamsen L, Lyrenas
S, Cnattinguis S.
Premature rupture of the membranes - intervention or
not.
Gynecol Obstet Invest.
1990;;
29
128-131
- 32
Ekman-Ordeberg
G, Uldbjerk N, Ulmsten
U.
Comparison of intravenous oxytocin and vaginal prostaglandin
E2 gel in women with unripe cervices and premature rupture of the
membranes.
Obstet Gynecol.
1985;;
66
307-310
- 33 Rath W. Fortschritte in der medikamentösen
Geburtseinleitung. H.U.F.-Verlag, Mühlheim (Ruhr); 1996:
- 34
van der Walt D, Venter
P F.
Management of term pregnancy with premature rupture of the
membranes and unfavorable cervix.
S Afr Med J.
1989;;
75
54-56
- 35
Mc Caul
J F, Rogers
L W, Perry K G et
al.
Premature rupture of the membranes at term with unfavorable
cervix: comparison of expectant management, vaginal prostaglandin, and oxytocin
induction.
South Med J.
1997;;
90
1229-1233
- 36
Gafni A, Goeree
R, Myhr T L et al.
Induction of labor versus expectant management for prelabor
rupture of the membranes at term: an economic evaluation. TERMPROM Study Group.
Term Prelabour Rupture of the membranes.
CMAJ.
1997;;
157
1519-1525
- 37
Guise J M, Duff
P, Christian J S.
Management of term patients with premature rupture of
membranes and an unfavorable cervix.
Am J Perinatol.
1992;;
9
56-60
- 38
Mozurkewich
E L, Wolf F M.
Premature rupture of the membranes at term: a metaanalysis of
three management schemes.
Obstet Gynecol.
1997;;
89
1035-1043
- 39
Hjertberg
R, Hammarström
M, Moberger B.
Premature rupture of the membranes at term in nulliparous
women with a ripe cervix.
Acta Obstet Gynecol Scand.
1996;
75
48-53
- 40
Burchell R C.
Premature spontaneous rupture of the membranes.
Am J Obstet Gynecol.
1964;;
88
251
- 41
Newton
E R, Prihoda
T J, Gibbs R S.
Logistic regression analysis of risk factors of
intra-amniotic infection.
Obstet Gynecol.
1989;
73
571-575
- 42
Seaward
P G, Hannah
M E, Myhr T L et
al.
International Multicentre Term Prelabor Rupture of Membranes
Study: evaluation of predictors of clinical chorioamnionitis and postpartum
fever in patients with prelabor rupture of membranes at term.
Am J Obstet Gynecol.
1997;;
177
1024-1029
- 43
Schutte
M F, Treffers
P E, Kloostermann G J et
al.
Management of PROM: The risk of vaginal examination to the
infant.
Am J Obstet Gynecol.
1983;;
146
395
- 44
Morales
W J, Lazar A J.
Expectant management of rupture of the membranes at
term.
South Med J.
1986;;
79
955-958
- 45
Egan D, O'Herlihy
C.
Expectant management of spontaneous rupture of the membranes
at term.
J Obstet Gynecol.
1988;;
8
243-247
- 46
Duff P.
Premature rupture of the membranes at term.
New Eng J Med.
1996;;
334
1005-1010
- 47
Panel Discussion.
Br J.
Obstet Gynaecol.
1997;;
104 Suppl 15
20-25
Dr. med. Lutz Rathmer
Marienkrankenhaus HamburgFrauenklinik
Alfredstraße 9
22087 Hamburg