Zusammenfassung
Berichtet wird über die Anwendung einer adjuvanten Chemotherapie mit Adriamycin (50
mg/m2 ) und Cyclophosphamid (600 mg/m2 ) bei einer 37 Jahre alten VIIG/IVP, bei der in der 16. Schwangerschaftswoche ein
pT1c pN0 (0/12) Mx-Karzinom der Mamma diagnostiziert wurde. Nach Mastektomie und Axilladissektion
wurden vier Therapiezyklen in dreiwöchentlichen Abständen appliziert. Nach primärer
Sectio in der 35. Schwangerschaftswoche bei Oligohydramnion und Wachstumsstillstand
sowie Beckenendlage kam es zu einer normalen kindlichen Entwicklung. Ein Vergleich
mit anderen Therapieformen bei Mammakarzinomen in der Schwangerschaft wird aufgezeigt.
Abstract
A 37-year-old G7P4 in the 16th gestational week presented with a 1.5 cm breast mass.
Biopsy showed grade 3 invasive carcinoma. The patient underwent mastectomy and axillary
dissection. Histology showed a pT1c pN0 tumor that stained negative for estrogen and
progesterone receptors. Adjuvantly the patient received four cycles of Adriamcyin
(50 mg/m2 ) and cyclophosphamide (600 mg/m2 ). Elective caesarean delivery was performed at 35 weeks' gestation because of intrauterine
growth retardation, oligohydramnios, and breech presentation. Postnatal development
was normal.
Literatur
1
Anderson, B. O.,, Petrek, J. A. , Byrd, D. R. , Senie, R. T. , Borgen P. I.
.
Pregnancy influences breast cancer stage at diagnosis in woman 30 years of age and
younger.
Ann. Surg. Oncol..
3 (2)
Mar 1996;
204-211
2
Barni, S.,, Ardizzoia, A. , Zanetta, G. , Strocchi, E. , Lissoni, P. , Tancini G.
.
Weekly doxorubicin chemotherapy for breast cancer in pregnancy. A case report.
Tumori.
78 (5)
Oct. 31, 1992;
349-350
3
Barrat, J.,, Marpeau, L. , Demuynck B. .
Breast cancer and pregnancy.
Rev. Fr. Gynecol. Obstet..
88 (11)
Nov. 1993;
544-549
4
DiFronzo, L. A.,, O'Connell T. X. .
Breast cancer in pregnancy and lactation.
Surg. Clin. North. Am..
76 (2)
Apr. 1996;
267-278
5
Dreicer, R.,, Love R. R. .
High total dose 5-fluorouracil treatment during pregnancy.
Wis. Med. J..
90 (10)
Oct. 1991;
582-583
6
Espie, M.,, Cuvier C. .
Treatment of breast cancer during pregnancy.
Contracept. Fertil. Sex..
24 (11)
Nov. 1996;
805-810
7
Fiorica, J. V..
Special problems. Breast cancer and pregnancy.
Obstet. Gynecol. Clin. North. Am..
21 (4)
Dec. 1994;
721-732
8
Gallenberg, M. M.,, Loprinzi C. I. .
Breast cancer and pregnancy.
Semin. Oncol..
16 (5)
Oct. 1989;
369-376
9
Hoover, H. C. .
Breast cancer during pregnancy and lactation.
Surg. Clin. North. Am..
70 (5)
Oct 1990;
1151-1163
10
Jereczek, B..
Breast cancer during pregnancy.
Ginecol. Pol..
66 (8)
Aug. 1995;
480-483
11
Marchant, D. J..
Breast cancer in pregnancy.
Clin. Obstet. Gynecol..
37 (4)
Dec. 1994;
993-997
12
Merkel, D. E..
Pregnancy and breast cancer.
Semi. Surg. Oncol..
12 (5)
Sep. - Oct. 1996;
370-375
13
Merviel, P.,, Salat-Baroux, J. , Uzan S. .
Breast cancer during pregnancy.
Bull. Cancer.
83 (4)
Apr. 1996;
266-275
14
Muller, T.,, Hofmann, J. , Steck T. .
Eklampsia after polychemotherapy for nodel-positive breast cancer during pregnancy.
Eur. J. Obstet. Gynecol. Reprod. Biol..
67 (2)
Aug. 1996;
197-198
15
Murray, E. M.,, Werner I. D. .
Pregnancy and abortion in breast cancer patients. Two case reports and a literature
review.
S. Afr. Med. J..
87 (11)
Nov. 1997;
1538-1539
16
Petrek, J. A..
Breast cancer during pregnancy.
Cancer.
74 (1)
Jul. 1994;
518-527
17
Petrek, J. A..
Breast cancer during pregnancy.
J. Natl. Cancer. Inst. Monogr..
16
1994;
113-121
18
Reichmann, B. S.,, Green K. B. .
Breast cancer in young women: effect of chemotherapy on ovarian function, fertility
and birth defects.
J. Natl. Cancer. Inst. Monogr..
16
1994;
125-129
19
Willemse, P. H.,, van der Sijde, R. , Sleijfer D. T. .
Combination chemotherapy and radiation for stage IV breast cancer during pregnancy.
Gynecol. Oncol..
36 (2)
Feb. 1990;
281-284
Prof. Dr. S. Schmidt
Direktor der Klinik für Geburtshilfe und Perinatalmedizin der Philipps-Universität
Marburg
Pilgrimstein 3
D-35033 Marburg