Welcome to the second 2025 issue of the International Journal of Epilepsy! As an editorial team, we are delighted to present this edition, which expands our
reach and fosters global collaboration in epilepsy research and clinical practice.
With heavy hearts, we remember
Prof P.A Mohammed Kunju
and invite you to read his heartfelt obituary in this issue by Prof Mini S - —a tribute
to a life that touched so many. This issue features two thought-provoking reviews
on pediatric epilepsy. The comprehensive review on developmental and epileptic encephalopathies
(DEEs) by Vinayan et al provides an overview of well-established DEE syndromes and
highlights available precision therapies, assisting clinicians in the effective evaluation
and management of affected children. The second review, by Valaparambil et al, explores
the intricate relationship between autism spectrum disorder and epilepsy, focusing
on shared neurobiological features such as synaptic dysfunction and imbalances in
excitation and inhibition, and discussing the implications for understanding their
co-occurrence.
In today's technologically advanced era, the In the Spotlight section on innovations in epilepsy, by Prof. Lakshmi Narasimhan Ranganathan, highlights
recent developments in epilepsy care. This includes innovations in pharmacological
therapies, surgical techniques, neurostimulation methods, and technological advances
aimed at seizure prediction and monitoring.
The original study by Anguelova et al, from the Netherlands, investigates the challenges
and potential of automated detection of interictal epileptiform discharges using deep
learning algorithms. While integrating artificial intelligence into clinical practice
holds promise, this research emphasizes the need for further refinement to achieve
accuracy comparable to expert human analysis. Shifting to genetic insights, Saadi
et al investigate the molecular underpinnings of infantile-onset epilepsy in Iraqi
children. With a high diagnostic yield and a predominance of autosomal recessive inheritance,
their findings provide valuable data for clinicians in similar regions and underscore
the importance of genetic testing in early-onset epilepsy. The study by Shivde et
al, from India, evaluates the clinical, neuroimaging, and electroencephalographic
profiles of patients with isolated nocturnal seizures, concluding that nocturnal seizures
may disrupt sleep architecture and impair quality of life.
We also present interesting cases in the Neuroimage of the Month (neurofibromatosis type-1) and EEG of the Month (idiopathic generalized epilepsy) sections. To further engage readers, we are pleased
to introduce another series of MCQs in this issue, encouraging participation to deepen
understanding of this complex and evolving field. Additionally, we feature abstracts
from ECON-2025, held from August 21 to 24, 2025, in Chennai, India. This premier national
conference, organized by the Indian Epilepsy Association and Indian Epilepsy Society,
showcased cutting-edge research and clinical advancements in epilepsy care.
Collectively, the articles in this issue underscore the multifaceted nature of epilepsy
and ongoing advancements in research and clinical practice aimed at improving the
lives of individuals affected by this condition. We hope this issue serves as a valuable
resource for clinicians, researchers, and all those dedicated to the field of epilepsy.
Sincerely,
The Editorial Team
