Download PDF
CC BY 4.0 · Journal of Coloproctology 2024; 44(S 01): S1-S138
DOI: 10.1055/s-0045-1808789
Enteroscopia, Colonoscopia e Pólipos
Enteroscopy, Colonoscopy, and Polyps
ID – 141768
E-poster

INFLUENCE OF LATERALITY ON THE ENDOSCOPIC AND HISTOPATHOLOGICAL CHARACTERISTICS OF PREMALIGNANT COLON LESIONS IN WOMEN AGED 60 YEARS AND OLDER

Rafaela de Melo Sprogis
1   Universidade de Brasília, Brasilia, Brazil
,
Vanessa Siqueira Reis
1   Universidade de Brasília, Brasilia, Brazil
,
Catarina Ferreira Costa Praia
1   Universidade de Brasília, Brasilia, Brazil
,
Luís Felipe Mendonça de Oliveira
1   Universidade de Brasília, Brasilia, Brazil
,
Flavia Berford Leão dos Santos Gonçalves de Oliveira
2   Hospital Universitário de Brasília, Brasília, Brazil
,
Camila Oliveira Barbosa
2   Hospital Universitário de Brasília, Brasília, Brazil
,
Bruno Augusto Alves Martins
2   Hospital Universitário de Brasília, Brasília, Brazil
,
João Batista de Sousa
1   Universidade de Brasília, Brasilia, Brazil
› Author Affiliations
› Further Information
Also available at
 
 PDF Download Permissions and Reprints

    Introduction The laterality of colon tumors influences clinical presentation and prognosis. These tumors often originate from premalignant lesions, which can be identified and characterized through colonoscopy and biopsy.

    Objective To analyze the influence of laterality on the endoscopic and histopathological characteristics of premalignant colon lesions in women aged 60 years and older.

    Method A retrospective, cross-sectional study of 4,412 consecutive colonoscopies performed in the coloproctology department of a university hospital between January 2019 and December 2023. The sample was limited to women aged 60 years and older, without previous intestinal resection, who underwent complete colonoscopies, presented with polyps during the examination, and whose histopathological analysis was conducted in the same service, totaling 262 patients. Each polyp found was individually analyzed for location, morphology, size, and histopathology. Polyps located at or distal to the splenic flexure were classified as left colon (LC), while those proximal to the splenic flexure were classified as right colon (RC). Statistical analysis was performed using Fisher's exact test and Chi-square test, with laterality as the dependent variable.

    Results A total of 510 polyps resected from the 262 patients were analyzed. Regarding location, 282 (55.3%) were in the LC, and 228 were in the RC. Morphologically, 234 (88%) of the LC polyps were sessile, while 208 (93.3%) in the RC had the same characteristic (p = 0.087). Polyps larger than 5 mm were observed in 45 (16.4%) cases in the LC and 39 (17.2%) in the RC (p = 0.901). In the LC, 135 (47.9%) polyps were histopathologically classified as hyperplastic, 109 (38.7%) as tubular adenomas, 23 (8.2%) as tubulovillous adenomas, and 6 (2.1%) as serrated adenomas. In the RC, 167 (73.2%) were classified as tubular adenomas, 33 (14.5%) as hyperplastic polyps, 15 (6.6%) as tubulovillous adenomas, and 8 (3.5%) as serrated adenomas (p < 0.001). Dysplasia was absent in 142 LC polyps (51.1%) and in 40 RC polyps (17.5%) (p < 0.001).

    Conclusion The RC was associated with a higher prevalence of tubular and serrated adenomas, while the LC was linked to hyperplastic polyps and the absence of dysplasia.


    #

    No conflict of interest has been declared by the author(s).

    Publication History

    Article published online:
    25 April 2025

    © 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit (https://creativecommons.org/licenses/by/4.0/)

    Thieme Revinter Publicações Ltda.
    Rua do Matoso 170, Rio de Janeiro, RJ, CEP 20270-135, Brazil

      Permissions and Reprints