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CC BY 4.0 · Arq Neuropsiquiatr 2024; 82(S 02): S53-S176
DOI: 10.1055/s-0045-1807080
ID: 692
Area: Others
Presentation method: Eletronic Poster

Aseptic conjunctivitis secondary to risperidone: case report

Authors

  • Juliana Dos Santos Cristovão

    1   Universidade Estadual Paulista, Botucatu SP, Brazil.
    2   Centro Universitário do Planalto Central Apparecido dos Santos, Brasília DF, Brazil.

  • Valkiria Kohlrausch Vidal Araujo

    1   Universidade Estadual Paulista, Botucatu SP, Brazil.
    2   Centro Universitário do Planalto Central Apparecido dos Santos, Brasília DF, Brazil.

  • Raphael Rocha Gomes Urbano

    1   Universidade Estadual Paulista, Botucatu SP, Brazil.
    2   Centro Universitário do Planalto Central Apparecido dos Santos, Brasília DF, Brazil.

  • Ada Maria Farias Sousa Borges

    1   Universidade Estadual Paulista, Botucatu SP, Brazil.
    2   Centro Universitário do Planalto Central Apparecido dos Santos, Brasília DF, Brazil.
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    *Correspondence: valkiria2002@hotmail.com.

    Abstract

    Case Presentation: This is a report of a 6-and-a-half-year-old child, with a diagnosis of Autistic Spectrum Disorder (ASD) support level 2 and ADHD (Attention Deficit Hyperactivity Disorder) as comorbidity. Pharmacological therapy with risperidone was initiated, with a gradual increase in dose up to 1.25 mL/day, divided into 2 doses, with significant improvement in aggressiveness, agitation, and impulsiveness, as well as evident gains in verbal communication. About 90 days after starting the drug, the mother reported increased appetite, abundant hyaline nasal discharge, and the presence of thick, yellowish eye discharge and red-eye syndrome. In ophthalmologic evaluation, the patient was refractory to the use of antiallergic medication, antibiotics, and lubricants. Due to the persistence of signs and symptoms, a gradual reduction of risperidone was chosen; however, the resolution of ocular complaints was only after the total suspension of the drug. Aripiprazole was subsequently started.

    Discussion: Risperidone is an atypical antipsychotic that has a high affinity for serotonin and dopamine receptors. Among the many situations in which this drug can be administered, it includes the treatment of irritability and aggressiveness associated with ASD. Although safe in the pediatric age group, the drug is not free of side effects. In the case described, the rare manifestation observed was aseptic conjunctivitis, and discontinuation was chosen due to refractory ocular hypersecretion.

    Final Comments: It is necessary that individuals undergoing pharmacological therapy with antipsychotics have continuous and longitudinal monitoring. Although the drug chosen is safe for use in pediatric patients, its use is not free of negative and unusual side effects, such as aseptic conjunctivitis. Knowing the indications and complications related to risperidone is important for the safety and clinical management of cases.


     

    Publication History

    Article published online:
    12 May 2025

    © 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit (https://creativecommons.org/licenses/by/4.0/)

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