Negative Pressure Therapy for Post-Operative Complications: Endoscopic Application Based on Single-Center Experience

Aims Anastomotic leaks are a significant complication following gastrointestinal surgery, often leading to increased morbidity and prolonged hospitalization. This study evaluates the efficacy of endoscopic negative pressure therapy (ENPT) in managing anastomotic leaks and explores potential additional applications of the technique.

Methods A retrospective analysis was conducted on patients who experienced anastomotic leaks and were treated with ENPT at our institution from June 2022 to October 2024. Data on demographics, leak characteristics, treatment protocols, and outcomes were collected. The primary endpoint was the rate of successful leak closure. Secondary endpoints included complications, duration of treatment, and potential additional applications of negative pressure therapy.

Results A total of 10 patients (6 males, mean age 71 years) were included in the study. Indications for treatment included anastomotic leak after subtotal/total gastrectomy (50%), rectal stump leakage (20%), anastomotic leak after anterior rectal resection (10%), duodenal fistula (10%), and jejunal fistula (10%). ENPT successfully achieved leak closure in 80% of cases. No adverse events were reported. The treatment required an average of 4 endoscopic revisions performed weekly over a mean duration of 24 days. Two patients were treated on an outpatient basis.

Conclusions Our experience suggests that ENPT is a safe and effective intervention for managing anastomotic leaks, with a high success rate and minimal complications. The technique shows promise not only for anastomotic leaks but also for enteric fistulas, indicating its potential for broader applications in gastrointestinal and endoscopic practice. Further studies are needed to establish standardized protocols.

Conflicts of Interest

Authors do not have any conflict of interest to disclose.

Publication History

Article published online:
27 March 2025