A Large Population-Based Study on Patients with Meningioma Using the Surveillance, Epidemiology, and End Results Database

Introduction: Meningiomas are the most common benign tumors found in the central nervous system. The incidence of these tumors has been increasing. To fully comprehend the impact of meningiomas on public health and elucidate the key prognostic factors, we undertake a systematic epidemiological evaluation and conduct large-scale survival analysis.

Materials and Methods: From 2000 to 2020, patients with meningioma were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. Patient sex, patient age, patient race, patient household income, and patient house location (rural/suburban/urban) were selected as prognostic indicators. Univariate and multivariable Cox proportional hazard models were run to identify prognostic factors that had a significant impact on overall survival (OS). Kaplan–Meier survival curves were made for statistically significant factors. A predictive nomogram was built to predict 5- and 10-year survival probability.

Results: This retrospective cohort includes 139,222 patients with meningioma. Based on our literature review, this is the largest retrospective cohort study on this patient population. There are 456 deaths reported during the period of this study. Male patients have a poorer OS compared with female patients (p < 0.001). Ages 19 to 65 years and ages older than 65 have poorer OS compared with ages birth to 18 years (p < 0.001). African American patients have a poorer OS compared with white patients (p < 0.001). Patients with an income >$75,000 have a better OS compared with patients with an income <$75,000 (p < 0.001). Patients living in urban cities have a better OS compared with patients living in rural cities (p < 0.001). The nomogram demonstrates acceptable accuracy in estimating the 5-year and 10-year survival probability, with C-index of 0.70 (95% CI: 0.69–0.71).

Conclusion: This study highlights some of the key epidemiological factors that impact prognosis in patients with meningiomas. The nomogram provides a reliable system to assess survival probability in guiding clinical decision making.

No conflict of interest has been declared by the author(s).

Publication History

Article published online:
07 February 2025