J Neurol Surg B Skull Base 2025; 86(S 01): S1-S576
DOI: 10.1055/s-0045-1803571
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How Important Is Complete Surgical Resection for Survival of Acute Invasive Fungal Sinusitis? Case Series and Review of the Literature

Authors

  • Chelsey Witsberger

    1   University of Michigan, Ann Arbor, Michigan, United States

  • Mary Kress

    1   University of Michigan, Ann Arbor, Michigan, United States

  • Erin McKean

    1   University of Michigan, Ann Arbor, Michigan, United States
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    Objectives: Describe cases in which complete surgical resection was not required to survive acute invasive fungal sinusitis (AIFS). Compare patient demographics, disease extent, and treatment in these patients with those who underwent complete surgical resection of AIFS.

    Study Design: Retrospective case series at a single tertiary care institution.

    Results: Sixty-eight patients with acute invasive fungal sinusitis treated at our institution were identified. The cause of immune suppression in most cases included: bone marrow transplant (17), AML (14), type 2 diabetes mellitus (12), and chronic immunomodulator use (11). At the time of data analysis, 56% survived their infection despite incomplete or no surgical excision. Seven patients survived with medication management alone and all cases included treatment with IV antifungals.

    Conclusion: Complete surgical resection is not required to survive acute invasive fungal sinusitis in all cases. The complex risk-benefit equation of radical surgical excision must be carefully considered for each individual patient by their team of experienced physicians.


     

    No conflict of interest has been declared by the author(s).

    Publication History

    Article published online:
    07 February 2025

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