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DOI: 10.1055/s-0044-1795512
DISTRIBUTION OF SINGLE NUCLEOTIDE POLYMORPHISMS (SNPS) IN GENES ASSOCIATED TO REPAIR, DETOXIFICATION, AND IMMUNE SYSTEM IN RURAL WORKERS WITH CANCER TREATED AT A REFERENCE HOSPITAL IN THE STATE OF GOIÁS
Authors
Occupational exposure to pesticides can damage the health of farmers, causing a series of diseases, including cancer. In this sense, we carried out a case-control study. The case group consisted of 54 farmers exposed to pesticides who underwent or are undergoing treatment at Hospital Araújo Jorge (HAJ) for head and neck, gastric, and hematological cancers. In addition, the control group consisted of 40 rural workers also exposed to pesticides but without a history of neoplasms. There were no differences in life habits, age, and sex in the sample group. Thus, this study aimed to characterize the sociodemographic groups, the frequency of use of PPE, and the geographical distribution of cases of head and neck cancer, gastric, and hematology in the state of Goiás. In addition, it was observed whether there was an association between polymorphisms of the PON1, XRCC1, IL6, IL6R, TNF-a, and MIR137 genes for developing head and neck, gastric, and hematological cancers. The most frequent cancers were multiple myeloma 12%, non-Hodgkin lymphoma 9%, and gastric adenocarcinoma 7%. Regarding the distribution of cancer among farmers in the State of Goiás, Rio Verde, Jataí Goianésia, and Itapuranga were the most prevalent cities ranging from 71 to 224 cases number. It is worth mentioning that to verify the distribution of cases of farmers with cancer treated at the HAJ, more than 1,000 medical records were analyzed. For pesticides, the most cited were insecticides (n=21, 32%), and the crops were grain production (45%). As for the distribution of allelic and genotypic frequencies of the 7 SNPs, in the case group, rs1625579 (MIR1 37) and rs1800795 (TNF-alpha) are not in Hardy-Weinberg equilibrium (p > 0.05), demonstrating that some evolutionary factor, such as mutations, may have increased the frequency of deleterious alleles. In addition, when comparing the distribution of wild-type and mutated alleles of the 7 SNPs between the sample group, a higher frequency of mutated alleles in workers with cancer was observed for SNPs rs1625579 (MIR-137), rs2228145 (IL-6), rs1800795 and 361525 (TNF-alpha), and rs662 (PON1). These findings showed that there might be a positive relationship between the risk and development of cancer when farmers are occupationally exposed to pesticides, regarding the presence of a mutated allele associated to repair, detoxification, or immune system genes.
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03. November 2022
© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit (https://creativecommons.org/licenses/by/4.0/)
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Thays Millena Alves Pedroso, Laura de Sousa Lopes, Miller Caldas Barradas, Elza Maria Gonçalves Uchoa, Hemily Gonçalves Ribeiro, Damiana Mirian da Cruz e Cunha, Fernanda Ribeiro Godoy, Fabiana Gonçalves dos Reis, Daniela de Melo e Silva. DISTRIBUTION OF SINGLE NUCLEOTIDE POLYMORPHISMS (SNPS) IN GENES ASSOCIATED TO REPAIR, DETOXIFICATION, AND IMMUNE SYSTEM IN RURAL WORKERS WITH CANCER TREATED AT A REFERENCE HOSPITAL IN THE STATE OF GOIÁS. Brazilian Journal of Oncology 2022; 18.
DOI: 10.1055/s-0044-1795512