Background Despite best intentions and even when producing beneficial outcomes, public health
interventions can cause adverse and other unintended consequences (AUCs). These are
usually not systematically examined in the development, evaluation, or implementation
of public health interventions. The objective of this research project was to develop
a framework intended to guide the anticipation and assessment auf AUCs of public health
interventions.
Methods We employed the ‘best-fit’ synthesis approach: an a priori framework was used as
a starting point and iteratively revised based on evidence identified through systematic
reviews of the scientific literature. The a priori framework was advanced in an iterative
process, based on a thematic analysis of systematic reviews of theoretical and conceptual
studies as well as systematic reviews focused on AUCs of public health interventions.
This preliminary framework coded against four systematic reviews addressing AUCs of
four different public health interventions to validate it.
Results The Consequences of Public Health Interventions (CONSEQUENT) framework includes two
components: the first focuses on AUCs and serves to categorize them; the second (supplementary)
component highlights the mechanisms through which AUCs may arise. The consequences
component comprises eight domains of AUCs: (i) health, (ii) health system, (iii) human
rights, (iv) acceptability and adherence, (v) equality and equity, (vi) social and
institutional, (vii) economic and resource-related, (viii) and the environment. The
mechanisms component consists of eight mechanisms, through which AUCs might arise.
It also offers structured definitions and examples for each of these domains, as well
as of the potential mechanisms leading to them.
Conclusion The CONSEQUENT framework can serve as a tool for researchers to assess and classify
adverse and other unintended consequences of a broad range of public health interventions
and to explore underlying mechanisms. The framework may facilitate structured reflections
on the adverse and other unintended consequences while developing, evaluating, and
implementing a broad range of heterogenous public health interventions. In upcoming
studies, we aim to evaluate and further refine the framework through practical application.