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CC BY 4.0 · Arq Neuropsiquiatr 2024; 82(S 01): S1-S52
DOI: 10.1055/s-0044-1789411
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The effect of total dietary antioxidant capacity (TDAC) in clinical and nutritional status in people with neuromyelitis optica spectrum disorder

Authors

  • Carine Costa dos Santos

    1   Universidade Estadual do Ceará, Fortaleza CE, Brazil.

  • Renan Souto Pereira

    1   Universidade Estadual do Ceará, Fortaleza CE, Brazil.

  • Alane de Sousa Nascimento Almeida

    1   Universidade Estadual do Ceará, Fortaleza CE, Brazil.

  • Pedro Henrique Aragão Gomes

    1   Universidade Estadual do Ceará, Fortaleza CE, Brazil.

  • Larissa Lara de Sousa Avelino

    1   Universidade Estadual do Ceará, Fortaleza CE, Brazil.

  • Ana Luísa Araújo Brito

    1   Universidade Estadual do Ceará, Fortaleza CE, Brazil.

  • Virna Luisa Nogueira Mesquita Braga

    1   Universidade Estadual do Ceará, Fortaleza CE, Brazil.

  • Lia Gomes Crisóstomo Sabóia

    1   Universidade Estadual do Ceará, Fortaleza CE, Brazil.

  • Ana Beatriz Soares Pontes

    1   Universidade Estadual do Ceará, Fortaleza CE, Brazil.

  • Ana Clara Sousa de Queiroz Campos

    1   Universidade Estadual do Ceará, Fortaleza CE, Brazil.

  • Rachel Elizabete Nascimento Serpa

    1   Universidade Estadual do Ceará, Fortaleza CE, Brazil.

  • Victor Vincent Morais de Lima

    1   Universidade Estadual do Ceará, Fortaleza CE, Brazil.

  • Gabriela Joca Martins

    2   Hospital Geral de Fortaleza, Fortaleza CE, Brazil.

  • Lorena do Nascimento Rocha Mapurunga

    2   Hospital Geral de Fortaleza, Fortaleza CE, Brazil.

  • Keyla Rejane Frutuoso de Morais

    2   Hospital Geral de Fortaleza, Fortaleza CE, Brazil.

  • Carla Welch da Silva

    2   Hospital Geral de Fortaleza, Fortaleza CE, Brazil.

  • Paulo Sérgio Lisboa

    2   Hospital Geral de Fortaleza, Fortaleza CE, Brazil.

  • Paulo Filho Soares Marcelino

    2   Hospital Geral de Fortaleza, Fortaleza CE, Brazil.

  • Patrícia Chagas Rocha D’Almeida

    2   Hospital Geral de Fortaleza, Fortaleza CE, Brazil.

  • José Artur Costa D’Almeida

    2   Hospital Geral de Fortaleza, Fortaleza CE, Brazil.

  • Maria Luisa Pereira de Melo

    1   Universidade Estadual do Ceará, Fortaleza CE, Brazil.
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    Address for correspondence: Renan Souto Pereira (email: renanpereira.ce@gmail.com).

    Abstract

    Background: The environmental risk factors of neuromyelitis optica spectrum disorder (NMOSD) are not fully understood. Some evidence suggests the possible protective effects of antioxidants on the progression of disease.

    Objective: To analyze the total dietary antioxidant capacity (TDAC) and its relationship with the clinical and nutritional status of people with NMOSD.

    Methods: The present cross-sectional study was approved by the Human Research Ethics Committee of Hospital Geral de Fortaleza (no. 365.222). We included 37 patients with a definite diagnosis of NMOSD, and collected data on demographic, clinical, and anthropometric characteristics. We evaluated the Expanded Disability Status Scale (EDSS) score, body mass index (BMI) and percentage of body fat (BF%) that was calculated by bioelectrical impedance analysis (BIA). Two 24-hour dietary recalls were obtained, and the TDAC was estimated using the ferric reducing antioxidant potential (FRAP). The variables were expressed as simple frequencies, percentages, and mean, median, and standard deviation values. The normality of the data was verified by the Shapiro-Wilk test. To compare means, we used was the Mann-Whitney test (p < 0.05).

    Results: The mean age was of 41.9±13.5 years, and there was a predominance of female patients (33 out of 37; 89.2%). Regarding family income, 74,3% of the patients reported receiving 1 to 3 minimum wages, while 75.7% had more than 8 years of schooling, and 78.4% had no professional occupation. According to the BMI, overweight/obesity was prevalent (59.5%), but the BF% was normal in 67.6%. The median EDSS score was of 3.0. The TDAC had a median of 3.7 mmol/1,000kcal, characterizing a diet low in antioxidant nutrients. There were no associations between the TDAC and the EDSS score (p = 0.775), the TDAC and the BMI (p = 0.322), or the TDAC and the BF% (p = 0.231).

    Conclusion: Low consumption of antioxidant nutrients was not associated with clinical conditions or nutritional status.


     

    Die Autoren geben an, dass kein Interessenkonflikt besteht.

    Publikationsverlauf

    Artikel online veröffentlicht:
    02. Oktober 2024

    © 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit (https://creativecommons.org/licenses/by/4.0/)

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