Download PDF
Open Access
CC BY 4.0 · Arq Neuropsiquiatr 2024; 82(S 01): S1-S52
DOI: 10.1055/s-0044-1789363
Supplement

Impacts of environmental tobacco smoke on the onset and progression of multiple sclerosis: a systematic review

Authors

  • Marco Antônio Machado Schlindwein

    1   Universidade da Região de Joinville, Joinville SC, Brazil.

  • Marcelo de Moura Campos

    1   Universidade da Região de Joinville, Joinville SC, Brazil.

  • Leticia Breis

    1   Universidade da Região de Joinville, Joinville SC, Brazil.

  • Beatriz Sordi Chara

    1   Universidade da Região de Joinville, Joinville SC, Brazil.

  • Clara Sasse Scherer

    1   Universidade da Região de Joinville, Joinville SC, Brazil.

  • Vitória Augusta Piva Caminski

    1   Universidade da Região de Joinville, Joinville SC, Brazil.

  • Arthur Stedile Ribeiro Pacheco

    1   Universidade da Região de Joinville, Joinville SC, Brazil.

  • Gabriel Erzinger

    1   Universidade da Região de Joinville, Joinville SC, Brazil.

  • Ruan Carlos da Silva

    1   Universidade da Região de Joinville, Joinville SC, Brazil.

  • Mayra Emi Guinoza Inushi

    1   Universidade da Região de Joinville, Joinville SC, Brazil.

  • Murilo Luis Geremias

    1   Universidade da Região de Joinville, Joinville SC, Brazil.

  • Andre Matta

    2   Sem afiliação.

  • Marcus Vinicius Magno Gonçalves

    3   Neurovie, Departamento de Neurologia, Joinville SC, Brazil.
Further Information
Also available at
 
 PDF Download Permissions and Reprints

Address for correspondence: Marcelo de Moura Campos (email: marcelo.campos88@hotmail.com).

Abstract

Background: Multiple sclerosis (MS) is a chronic inflammatory, demyelinating, autoimmune disorder of the central nervous system (CNS) with a prevalence of ~ 140/100 thousand inhabitants in North America and of 108/100 thousand in Europe. The etiology of MS remains unclear, but environmental and lifestyle components, accompanied by genetic susceptibility, have been associated with an increased risk of developing MS. Tobacco smoking has been consistently reported as an MS environmental risk, increasing the propensity of developing such a disorder. Moreover, smoking is additionally mentioned as a risk factor for a more aggressive disease progression. Unlike cigarette smoking, environmental tobacco smoke (ETS) has not been well described as an environmental risk for the development of MS, nor as a risk factor for disease progression.

Methods: We reviewed the association between ETS and the risk of onset and/or progression of multiple sclerosis through a systematic screening of the PubMed/MEDLINE, Science Direct, LILACS, and SciELO databases in search of articles published between January 1st, 2010, and July 5th, 2021, with the following keywords: multiple sclerosis and smoking; multiple sclerosis and passive smoking; and multiple sclerosis and secondhand smoking.

Results: We included 15 articles in the review, comprising 2 meta-analyses, 2 systematic reviews, and 11 observational studies. The meta-analyses reported an impact of passive smoking on the onset of MS among passive smokers. Both systematic reviews mostly reported associations between smoking and the development of MS. Seven observational studies reported higher odds of MS onset when associated with passive smoking. And four observational studies did not show a relationship between passive smoking and MS development or progression.

Conclusion: Most articles showed a positive association between environmental tobacco smoke exposure and the risk of developing multiple sclerosis. On the other hand, an association between ETS and a higher risk for MS progression could not be established.


No conflict of interest has been declared by the author(s).

Publication History

Article published online:
02 October 2024

© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit (https://creativecommons.org/licenses/by/4.0/)

Thieme Revinter Publicações Ltda.
Rua do Matoso 170, Rio de Janeiro, RJ, CEP 20270-135, Brazil

  Permissions and Reprints