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CC BY 4.0 · Arq Neuropsiquiatr 2024; 82(S 01): S1-S52
DOI: 10.1055/s-0044-1789341
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Disability functional profile of patients with progressive multiple sclerosis and its association with disease-modifying therapy in a hospital in Northeastern Brazil

Matheus Rolim Mendes de Alencar
1   Hospital Geral de Fortaleza, Fortaleza CE, Brazil.
,
Ivna Lacerda Pereira Nóbrega
1   Hospital Geral de Fortaleza, Fortaleza CE, Brazil.
,
Igor Bessa
2   Hospital Geral de Fortaleza, Departamento de Neuroimunologia, Fortaleza CE, Brazil.
,
Paulo Sérgio Lisboa
2   Hospital Geral de Fortaleza, Departamento de Neuroimunologia, Fortaleza CE, Brazil.
,
Keyla Rejane
1   Hospital Geral de Fortaleza, Fortaleza CE, Brazil.
,
Rodrigo da Ponte Barbosa
1   Hospital Geral de Fortaleza, Fortaleza CE, Brazil.
,
Lucas Silvestre
2   Hospital Geral de Fortaleza, Departamento de Neuroimunologia, Fortaleza CE, Brazil.
,
Patrícia Chagas Rocha D’Almeida
1   Hospital Geral de Fortaleza, Fortaleza CE, Brazil.
,
Gabriela Martins
2   Hospital Geral de Fortaleza, Departamento de Neuroimunologia, Fortaleza CE, Brazil.
,
José Artur Costa D’Almeida
2   Hospital Geral de Fortaleza, Departamento de Neuroimunologia, Fortaleza CE, Brazil.
,
Milena Sales Pitombeira
2   Hospital Geral de Fortaleza, Departamento de Neuroimunologia, Fortaleza CE, Brazil.
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    Address for correspondence: Matheus Rolim Mendes de Alencar (email: matheus_alencar_1@hotmail.com).

    Abstract

    Background: Multiple sclerosis (MS) is a chronic, inflammatory, demyelinating disease of the central nervous system associated with neurodegeneration. Regarding treatment and epidemiological data about MS, there is a lack of scientific studies in Brazil and Latin America, mainly regarding the development of treatment protocols, as well as better strategies for clinical and diagnostic evaluations mainly in cases of the progressive forms of the disease.

    Objective: To evaluate the disability profile of patients with progressive MS followed up at a hospital in Northeastern Brazil.

    Methods: The present was a retrospective cohort study, which evaluated the disability profile of patients with progressive MS and the associations with treatment, between t 2020 and 2024. The disability profile was assessed by the Expanded Disability Status Scale from the analysis of medical records, along with available clinico-epidemiological data, using the BRANDO platform, a database developed by the Brazilian and the Latin American committee for studies in MS, for data collection, along with available clinico-epidemiological data. We also analyzed the association involving disability, clinical, and disease-modifying therapy (DMT).

    Results: We included 42 patients with a PMS diagnosis, 26 (61.9%) of whom were female. The median EDSS score was of 6.5 (range: 1.5–9.5), which is in line with the impairment in labor activities observed in this cohort, as 34 (80.9%) patients were reported as retired or unemployed due to MS. Age was correlated with greater disability, while no significant difference was observed between the samples as to the disease progression and DMT use.

    Conclusion: Significant disability and high work impairment were observed in the population with PMS analyzed. Older age was the only factor correlated with higher EDSS scores in our sample. New studies will be necessary to better evaluate the patients disability profile, including a complete approach and more broad functional tests in a systematic way to better monitor the patient and evaluate therapeutic response.


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    Die Autoren geben an, dass kein Interessenkonflikt besteht.

    Publikationsverlauf

    Artikel online veröffentlicht:
    02. Oktober 2024

    © 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit (https://creativecommons.org/licenses/by/4.0/)

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