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CC BY 4.0 · Arq Neuropsiquiatr 2024; 82(S 01): S1-S52
DOI: 10.1055/s-0044-1789340
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Patient-reported outcomes (SymptoMScreen) in a Brazilian scenario: most common symptoms and their correlations with conventional scales

Mateus Boaventura de Oliveira
1   Universidade de São Paulo, Faculdade de Medicina, Hospital das Clínicas, São Paulo SP, Brazil.
,
Larissa Cruz Gatti
2   Hospital São Camilo, São Paulo SP, Brazil.
,
Murilo Pinoti
2   Hospital São Camilo, São Paulo SP, Brazil.
,
Olivia Pires
3   Centro Universitário São Camilo, São Paulo SP, Brazil.
,
Clayton Zoccoli
2   Hospital São Camilo, São Paulo SP, Brazil.
,
Isabella Avolio
3   Centro Universitário São Camilo, São Paulo SP, Brazil.
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    Address for correspondence: Mateus Boaventura de Oliveira (email: mateusboaventura@yahoo.com.br.

    Abstract

    Background: Multiple sclerosis (MS) is an autoimmune and polysymptomatic disease with a relevant need for recording and monitoring symptoms. In this scenario, patient-reported outcomes (PROs) are important to measure the impact of the disease and to monitor issues such as silent progression. The SymptoMScreen was developed in 2017 and is designed to evaluate the impact of MS symptoms through 12 neurological domains. It is a quick user-friendly scale with high reproducibility, easy access, previous use in clinical trials, and potential association with well-known scales.

    Objective: To describe the most common debilitating symptoms in MS patients by using the SymptoMScreen and its correlations in a Brazilian setting.

    Methods: The present is an observational, cross-sectional study, conducted in an MS Outpatient Clinic where this PRO is routinely applied. The median of the global SymptoMScreen score was calculated and correlated with: the Expanded Disability Status Scale (EDSS), the Timed 25-Foot Walk (T25FW), the Nine-Hole Peg Test (9HPT), the Symbol Digit Modalities Test (SDMT), the California Verbal Learning Test (CVLT), the Brief Visuospatial Memory Test – Revised (BVMT-R), the Multiple Sclerosis Impact Scale (MSIS-29), and the Modified Fatigue Impact Scale (MFIS).

    Results: The study included 123 MS patients (with a mean age of 38.3±10.5 years, 76.4% of female subjects; a mean disease duration of 9.5±7.5 years, and a median baseline EDSS score of 2.0). The three most affected domains were fatigue, cognition, and anxiety. The global SymptoMScreen score was significantly associated with the scores on the EDSS (r = 0.561; p < 0.001), T25FW (r = 0.370; p < 0.001), 9HPT (r = 0.352; p = 0.007), MSIS-29 (r = 0.556; p < 0.001), and MFIS (r = 0.448, p < 0.001). Concerning correlations with the SDMT, CVLT and BVMT-R, only trends were observed.

    Conclusion: The SymptoMScreen is a high-quality valuable tool for documenting and addressing patient symptoms in clinical settings, and it may support remote monitoring. The global score was significantly correlated with conventional scales in the present study.


     

    No conflict of interest has been declared by the author(s).

    Publication History

    Article published online:
    02 October 2024

    © 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit (https://creativecommons.org/licenses/by/4.0/)

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