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CC BY 4.0 · World J Nucl Med 2024; 23(04): 307-311
DOI: 10.1055/s-0044-1788793
Case Report

Unusual “Mini-Rugby Ball” Pattern Solitary Lung Metastasis in Relapsed Ewing's Sarcoma

Abhay Gondhane
1   Radiation Medicine Centre, Bhabha Atomic Research Centre, Tata Memorial Hospital Annexe, Jerbai Wadia Road, Parel, Mumbai, Maharashtra, India
2   Homi Bhabha National Institute, Mumbai, Maharashtra, India
,
Sunita N. Sonavane 
1   Radiation Medicine Centre, Bhabha Atomic Research Centre, Tata Memorial Hospital Annexe, Jerbai Wadia Road, Parel, Mumbai, Maharashtra, India
2   Homi Bhabha National Institute, Mumbai, Maharashtra, India
,
Sandip Basu 
1   Radiation Medicine Centre, Bhabha Atomic Research Centre, Tata Memorial Hospital Annexe, Jerbai Wadia Road, Parel, Mumbai, Maharashtra, India
2   Homi Bhabha National Institute, Mumbai, Maharashtra, India
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Abstract

Ewing's sarcoma (ES) is a mesenchymal origin malignant neoplasm that affects children and adolescents. It is the second most common type of bone sarcoma and accounts for approximately 1.5% of all childhood cancers with an annual incidence of 1 to 3 cases per million children under 16 years of age. In this article, we present the case of a 16-year-old adolescent girl. Lung metastasis at the initial diagnosis of ES is relatively uncommon but carries significant prognostic implications. Lung metastases in ES can vary significantly in size, ranging from small nodules (just a few millimeters in size) to the largest reported case being 15 cm. The size of the metastases impacts the choice of therapeutic strategies and the prognosis. Approximately 30% of patients with ES experience a relapse, with the lungs being a common site for metastatic disease. Relapsed lung metastasis on follow-up is a critical concern in the long-term management of ES. We describe a relapsed case of ES in a 16-year-old adolescent girl who presented with a solitary large metastatic right lung mass, with the longest dimension of 16 cm on craniocaudal measurement. The primary site of the tumor was the left distal femur, for which the patient received six cycles of neoadjuvant chemotherapy, followed by en bloc tumor excision and rotationplasty of the left distal femur, after which the patient received seven cycles of adjuvant chemotherapy. Subsequent 5 years of regular follow-up was asymptomatic. Later, the patient presented with back pain and cough, and was diagnosed with a solitary large right lung mass. Computed tomography (CT) guided biopsy of the right lung mass revealed a metastatic ES, for which she underwent chemoradiotherapy. This case highlights the large size of solitary lung metastases in relapsed ES.


 

Keywords

Ewing's sarcoma - 18F-NaF - 18F-FDG - PET/CT - lung metastases

Introduction

Ewing's sarcoma (ES) was described for the first time in 1921 by James Stephen Ewing, American histopathologist, oncologist, and hematologist.[1] ES is a mesenchymal origin malignant neoplasm that affects children and adolescents. Its peak incidence is in the second decade of life, with the average age being 13 to 16 years.[2] It is the second most common type of bone sarcoma and it accounts for approximately 1.5% of all childhood cancers with an annual incidence is 1 to 3 cases per million children under 15 years of age.[3] Clinically it manifests as intermittent bone pain at the site of the primary bone involvement, which increases in intensity at night. Sometimes, pain is associated with fever, weight loss, and anorexia.[4] The most affected bone sites include metaphysis of the long bones (around 56%), costal arches (∼15–17%), flat bones (16%), and skull (3–4%).[5] The size of the primary ES tumor at presentation can vary widely, typically ranging from 5 to 10 cm in diameter.[5] The incidence of lung metastases at the primary presentation of ES ranges from 10 to 25%.[6] The most common route of metastases in ES is hematogenous, causing the lung, bone, bone marrow, and brain metastases. However, the lymphatic route is found less frequently.[7] Lung metastases in ES can vary significantly in size, from small nodules to large masses exceeding 10 cm in diameter.[8] Diagnosis of ES includes radiological imaging studies like X-rays of the primary site, computed tomography (CT), and magnetic resonance imaging (MRI). A definite diagnosis is by the histological evaluation of primary bone lesion. Histopathologically, the presence of a series of chromosomal translocations that culminate in the fusion of the EWSR1 gene on chromosome 22 with one of several members of the erythroblast transformation specific (ETS) family of transcription factors is the defining characteristic of these tumors. The most common of these translocations includes t (11;22) (q24;q12), which fuses the EWSR1 gene with the FLI1 gene on chromosome 11 and is present in approximately 90% of cases.[9] Treatment includes extensive surgery of the lesion with free section margins followed by chemotherapy and radiotherapy.[10] Chemotherapy can be before (neoadjuvant) or after surgery (adjuvant). The most commonly used regimens worldwide are VACA (vincristine, actinomycin, cyclophosphamide, doxorubicin) and VAC/IE (vincristine, cyclophosphamide, doxorubicin alternating with ifosfamide/etoposide).[9] The prognosis depends on age, clinical stage at diagnosis, and presence of metastases at the time of diagnosis.[10] Patients diagnosed early in the initial stages of the disease have a better survival. Mortality is high, especially in the first year after diagnosis in patients with lung metastases.[11]


 

Case Report

A 16-year-old adolescent girl presented with on and off episodes of fever, pain, and swelling over the distal part of the left thigh and knee joint. Left knee MRI showed altered marrow signal, appearing heterogeneously hyperintense on short tau inversion recovery (STIR) images and hypointense on T1-weighted images, noted in the distal diaphysis and metaphysis on the femur reaching up to the growth plate. Mild marrow edema in the distal epiphysis was noted as hyperintensity on STIR images. Periosteal reaction was noted with the presence of circumferential abnormal soft-tissue component measuring 7.6 × 6.4 cm in the transverse plane and 1.8 cm along the long axis. 18Fluorine-sodium fluoride (18F-NaF) positron emission tomography/CT (PET/CT) scan was performed 60 minutes after intravenous injection of 9.43 mCi of 18F-NaF, using a whole-body full ring dedicated 3D PET/CT scanner covering from the vertex to the toe region. Whole-body noncontrast CT (100 mA, 120 kV, 2 mm) was acquired for attenuation correction and anatomical localization. Images were reconstructed using the standard iterative algorithm (RAMLA). Images were reformatted into transaxial, coronal and sagittal views, which showed the solitary site of increased tracer uptake (maximum standardized uptake value [SUVmax] of 10.98) in the left distal femur lesion ([Fig. 1]). No lung nodules, skip lesion, or any other site of skeletal abnormality were noted. Fine-needle aspiration cytology from the left distal femur lesion revealed small, monomorphic round cells with fine nuclear chromatin, irregularly vacuolated cytoplasm (periodic acid–Schiff [PAS] positive) and round nuclei, most likely ES. The patient received six cycles of neoadjuvant chemotherapy VIDE (vincristine, ifosfamide, doxorubicin, etoposide), which was followed by wide excision of the left distal femur lesion and limb salvage surgery, that is, rotational plasty of the left distal femur. Subsequently, the patient further received seven cycles of adjuvant chemotherapy VAI (vincristine, dactinomycin, ifosfamide), and VAC (vincristine, dactinomycin, cyclophosphamide). The patient was asymptomatic and was on regular follow-up for the subsequent 5 years. On follow-up, she presented with complaints of back pain and cough. Chest X-ray showed a large homogenous area of consolidation in the right lung field. Thus, a whole-body fluorine-18-fluorodeoxyglucose (18F-FDG) PET/CT scan was performed by a similar protocol as the previous PET scan after intravenous injection of 5.6 mCi of 18F-FDG. Scan findings revealed no abnormal tracer uptake at the site of the primary, with postoperative status and evidence of rotationplasty noted over the left distal femur. A solitary large hypermetabolic (SUVmax of 8.05) heterogenous soft-tissue lesion with central necrotic area was noted involving almost a significant area of the right lung parenchyma, measuring 10.7 × 11.2 × 16 cm (anteroposterior [AP] × transverse [T] × craniocaudal [CC]), almost the size of a mini-rugby ball ([Fig. 2]). Further CT-guided biopsy of the right lung mass revealed a metastatic ES. Subsequently, in view of the relapsed ES presenting as pulmonary mass, the patient received eight cycles of salvage chemotherapy with the VTC (vincristine, topotecan, cyclophosphamide) regimen. Postchemotherapy CT scan of the chest showed a decrease in the size of the solitary metastatic lesion in the right lung, measuring 7.1 × 9.5 × 13 cm (AP × T × CC). The rest of the lung parenchyma was unremarkable. In view of the significant size of the residual lesion, the patient received external beam radiotherapy (EBRT), 55.8 Gy in 31 fractions to the right lung mass. The patient is on follow-up and is stable, under observation at present. The presented case highlights an unusual large-sized solitary lung metastasis in a relapsed patient of ES.

Zoom
Fig. 1 (A) Anterior maximum intensity projection (MIP) of whole-body 18F-sodium fluoride (18F-NaF) positron emission tomography (PET). Noncontrast computed tomography (CT; bone window), PET, and fused PET/CT: (B–D) axial, (E–G) coronal, and (H–J) sagittal images showing increased tracer uptake noted in the site of the primary bone tumor involving the left distal femur (maximum standardized uptake value [SUVmax] measuring 10.98).
Zoom
Fig. 2 (A) Anterior maximum intensity projection of whole-body 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET). Noncontrast computed tomography (CT; lung window), PET, and fused PET/CT: (B–D) axial, (E–G) coronal, and (H–J) sagittal images showing metabolically active heterogenous soft-tissue lesion with central necrotic area involving almost a significant area of the right lung parenchyma, measuring 10.7 × 11.2 × 16 cm (maximum standardized uptake value [SUVmax] of 8.05).

 

Discussion

ES is a rare and aggressive malignancy that primarily affects children and young adults.[12] Karski et al[13] and Ramkumar et al[14] reported that advanced age may increase the probability of metastasis of ES. Our patient was diagnosed at 16 years of age and at the time of relapse and diagnosis of lung metastases, she was 23 years of age. Primary ES of the lung is exceedingly rare, with only 17 cases identified in the literature.[15] Thomas et al reported thoracic ES in an 18-year-old man.[16] The incidence of lung metastases at the primary presentation of ES ranges from 10 to 25%.[6] [17] A primary tumor size more than 8 cm has an increased likelihood of having metastatic diseases at initial diagnosis.[18] The presentation of lung metastases at the initial diagnosis of ES is relatively uncommon, but carries significant prognostic implications.[19] This early dissemination indicates a more aggressive disease course and necessitates comprehensive staging at diagnosis.[20] The main treatment modality for the primary ES lesion is surgery with en bloc resection of the tumor and nearby soft tissues or amputation of the limb; in particular cases, limb salvage surgery is proposed.[1] [2] In Sanchez-Saba et al's[9] study of 88 patients of ES of bone treated with preoperative chemotherapy and limb-sparing surgery, the overall survival rates were 79.5% at 2 years, 69% at 5 years, and 64% at 10 years. According to them, limb-sparing surgery associated with pre- and postoperative chemotherapy should be the treatment for ES of bone that meets certain requirements that allow its performance.

During treatment, lung metastases can be detected using imaging modalities such as CT and PET scans.[21] The detection of new metastases during therapy often requires a modification of the treatment plan, including possible escalation of chemotherapy or consideration of surgical interventions.[22] Studies have shown that approximately 30% of patients with ES experience a relapse, with the lungs being a common site for metastatic disease.[23] [24] The largest lung metastases from ES reported in the literature measured over 15 cm.[25] The size of the metastases can impact the choice of therapeutic strategies and the prognosis.[26] Such extensive disease poses significant therapeutic challenges and often requires multimodal treatment approaches.[26] Lung metastases in ES are relatively rare compared with other sites of metastases such as bones and bone marrow.[27] Novel diagnostic features include the use of molecular imaging and liquid biopsies to detect circulating tumor cells and DNA.[28] Large lung metastases present significant therapeutic challenges, including the difficulty of achieving complete surgical resection and the limited efficacy of radiation therapy for bulky disease.[29] Chemotherapy remains a mainstay treatment, but high-dose regimens are often required.[30] There are ongoing controversies in the treatment of lung metastases in ES, particularly regarding the role of surgical resection versus nonsurgical approaches.[5] Some studies advocate for aggressive surgical management, while others suggest that systemic therapy alone may be sufficient in certain cases.[31] Management dilemmas include deciding on the timing and extent of surgical intervention, the use of adjuvant therapies, and balancing treatment efficacy with quality-of-life considerations.[32] Multidisciplinary teams are essential in navigating these complex decisions to optimize patient outcomes.[22] At relapse for the solitary large metastatic lung lesion of ES, in the present case, the patient was given chemotherapy and external radiotherapy. However, there was persistent residual disease and necessitated further treatment. We highlight the rarity in view of the large size of the metastatic lung lesion.


 

 

Conflict of Interest

None declared.


Address for correspondence

Sandip Basu, MBBS (Hons), DRM, DNB, MNAMS
Radiation Medicine Centre (BARC), Tata Memorial Hospital Annexe
Jerbai Wadia Road, Parel, Mumbai 400012, Maharashtra
India   

Publikationsverlauf

Artikel online veröffentlicht:
06. August 2024

© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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Zoom
Fig. 1 (A) Anterior maximum intensity projection (MIP) of whole-body 18F-sodium fluoride (18F-NaF) positron emission tomography (PET). Noncontrast computed tomography (CT; bone window), PET, and fused PET/CT: (B–D) axial, (E–G) coronal, and (H–J) sagittal images showing increased tracer uptake noted in the site of the primary bone tumor involving the left distal femur (maximum standardized uptake value [SUVmax] measuring 10.98).
Zoom
Fig. 2 (A) Anterior maximum intensity projection of whole-body 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET). Noncontrast computed tomography (CT; lung window), PET, and fused PET/CT: (B–D) axial, (E–G) coronal, and (H–J) sagittal images showing metabolically active heterogenous soft-tissue lesion with central necrotic area involving almost a significant area of the right lung parenchyma, measuring 10.7 × 11.2 × 16 cm (maximum standardized uptake value [SUVmax] of 8.05).