Metabolic Bone Diseases: Recommendations for Interventional Radiology

Abstract

Metabolic bone diseases (MBDs), including osteoporosis, osteomalacia, and Paget's disease, represent a significant challenge in medical imaging and intervention. Interventional radiologists play a pivotal role in managing these conditions, due to the crucial role of detailed and precise imaging in diagnosing and treating MBDs. This article offers comprehensive recommendations aimed at optimizing interventional radiologic practices for patients with MBDs, highlighting the importance of using advanced imaging modalities, including dual-energy X-ray absorptiometry and magnetic resonance imaging, essential for accurate assessment of bone mineral density and architecture, guiding effective intervention strategies. We also discuss the use of minimally invasive procedures like vertebroplasty and biopsy, vital for both diagnostic and therapeutic purposes, to enhance diagnostic accuracy and therapeutic outcomes, ensuring high-quality patient management in the context of MBDs.

Keywords

metabolic bone disease - vertebroplasty - bone biopsy - osteoporosis

Publikationsverlauf

Artikel online veröffentlicht:
15. Oktober 2024

• References

• 1 Komoroski M, Azad N, Camacho P. Disorders of bone and bone mineral metabolism. Handb Clin Neurol 2014; 120: 865-887
• 2 Natesan V, Kim SJ. Metabolic bone diseases and new drug developments. Biomol Ther (Seoul) 2022; 30 (04) 309-319
• 3 Shen Y, Huang X, Wu J. et al. The global burden of osteoporosis, low bone mass, and its related fracture in 204 countries and territories, 1990–2019. Front Endocrinol (Lausanne) 2022; 13: 882241
• 4 Chang CY, Rosenthal DI, Mitchell DM, Handa A, Kattapuram SV, Huang AJ. Imaging findings of metabolic bone disease. Radiographics 2016; 36 (06) 1871-1887
• 5 Muto M, Guarnieri G, Giurazza F, Manfrè L. What's new in vertebral cementoplasty?. Br J Radiol 2016; 89 (1059) 20150337
• 6 Grados F, Depriester C, Cayrolle G, Hardy N, Deramond H, Fardellone P. Long-term observations of vertebral osteoporotic fractures treated by percutaneous vertebroplasty. Rheumatology (Oxford) 2000; 39 (12) 1410-1414
• 7 Dempster DW, Compston JE, Drezner MK. et al. Standardized nomenclature, symbols, and units for bone histomorphometry: a 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee. J Bone Miner Res 2013; 28 (01) 2-17
• 8 Picard S, Mayemba CN, Ung RV, Martel S, Mac-Way F. Division of an iliac crest bone biopsy specimen to allow histomorphometry, immunohistochemical, molecular analysis, and tissue banking: technical aspect and applications. JBMR Plus 2020; 4 (12) e10424
• 9 Lopes D, Martins-Cruz C, Oliveira MB, Mano JF. Bone physiology as inspiration for tissue regenerative therapies. Biomaterials 2018; 185: 240-275
• 10 Raubenheimer EJ, Noffke CE, Hendrik HD. Recent developments in metabolic bone diseases: a gnathic perspective. Head Neck Pathol 2014; 8 (04) 475-481
• 11 Föger-Samwald U, Dovjak P, Azizi-Semrad U, Kerschan-Schindl K, Pietschmann P. Osteoporosis: pathophysiology and therapeutic options. EXCLI J 2020; 19: 1017-1037
• 12 Clynes MA, Harvey NC, Curtis EM, Fuggle NR, Dennison EM, Cooper C. The epidemiology of osteoporosis. Br Med Bull 2020; 133 (01) 105-117
• 13 Zimmerman L, McKeon B. . Osteomalacia . StatPearls Publishing. Available at: https://www.ncbi.nlm.nih.gov/books/NBK551616/ . Accessed July 1, 2024
• 14 Nebot Valenzuela E, Pietschmann P. Epidemiology and pathology of Paget's disease of bone—a review. Wien Med Wochenschr 2017; 167 (1-2): 2-8
• 15 Guglielmi G, Muscarella S, Leone A, Peh WC. Imaging of metabolic bone diseases. Radiol Clin North Am 2008; 46 (04) 735-754 , vi
• 16 Mattera M, Reginelli A, Bartollino S. et al. Imaging of metabolic bone disease. Acta Biomed 2018; 89 (1-S): 197-207
• 17 Harvey NC, Glüer CC, Binkley N. et al. Trabecular bone score (TBS) as a new complementary approach for osteoporosis evaluation in clinical practice. Bone 2015; 78: 216-224
• 18 Sheu A, Diamond T. Bone mineral density: testing for osteoporosis. Aust Prescr 2016; 39 (02) 35-39
• 19 Stagi S, Cavalli L, Cavalli T, de Martino M, Brandi ML. Peripheral quantitative computed tomography (pQCT) for the assessment of bone strength in most of bone affecting conditions in developmental age: a review. Ital J Pediatr 2016; 42 (01) 88
• 20 Hans D, Baim S. Quantitative ultrasound (QUS) in the management of osteoporosis and assessment of fracture risk. J Clin Densitom 2017; 20 (03) 322-333
• 21 Hans D, Métrailler A, Gonzalez Rodriguez E, Lamy O, Shevroja E. Quantitative ultrasound (QUS) in the management of osteoporosis and assessment of fracture risk: an update. Adv Exp Med Biol 2022; 1364: 7-34
• 22 Sollmann N, Löffler MT, Kronthaler S. et al. MRI-based quantitative osteoporosis imaging at the spine and femur. J Magn Reson Imaging 2021; 54 (01) 12-35
• 23 Glickman SG, Marn CS, Supiano MA, Dengel DR. Validity and reliability of dual-energy X-ray absorptiometry for the assessment of abdominal adiposity. J Appl Physiol (1985) 2004; 97 (02) 509-514
• 24 Choksi P, Jepsen KJ, Clines GA. The challenges of diagnosing osteoporosis and the limitations of currently available tools. Clin Diabetes Endocrinol 2018; 4: 12
• 25 Colazo JM, Quirion J, Judice AD. et al. Utility of iliac crest tetracycline-labelled bone biopsy in osteoporosis and metabolic bone disease: an evaluation of 95 cases over a period of 25 years. Bone Rep 2023; 19: 101715
• 26 Bhan A, Qiu S, Rao SD. Bone histomorphometry in the evaluation of osteomalacia. Bone Rep 2018; 8: 125-134
• 27 Seitz S, Priemel M, Zustin J. et al. Paget's disease of bone: histologic analysis of 754 patients. J Bone Miner Res 2009; 24 (01) 62-69
• 28 Treurniet S, Eekhoff EMW, Schmidt FN, Micha D, Busse B, Bravenboer N. A clinical perspective on advanced developments in bone biopsy assessment in rare bone disorders. Front Endocrinol (Lausanne) 2020; 11: 399
• 29 Johnson KA, Kelly PJ, Jowsey J. Percutaneous biopsy of the iliac crest. Clin Orthop Relat Res 1977; (123) 34-36
• 30 Masood S, Mallinson PI, Sheikh A, Ouellette H, Munk PL. Percutaneous bone biopsy. Tech Vasc Interv Radiol 2022; 25 (01) 100800
• 31 Spinnato P, Colangeli M, Rinaldi R, Ponti F. Percutaneous CT-guided bone biopsies: indications, feasibility and diagnostic yield in the different skeletal sites—from the skull to the toe. Diagnostics (Basel) 2023; 13 (14) 2350
• 32 Lavigne F, Desbiens LC, Garneau G, Côté F, Mac-Way F. Iliac crest bone biopsy by interventional radiologists to improve access to bone biopsy in chronic kidney disease populations: technical note and a case series. J Nephrol 2021; 34 (03) 901-906
• 33 Byrd JJ, Snow EL, McCumber TL. Iliac bone biopsy and analysis: a clinical, translational, and cadaveric review. Transl Res Anat 2023; 31: 100245
• 34 Allen RT, Kum JB, Weidner N, Hulst JB, Garfin SR. Biopsy of osteoporotic vertebral compression fractures during kyphoplasty: unsuspected histologic findings of chronic osteitis without clinical evidence of osteomyelitis. Spine 2009; 34 (14) 1486-1491
• 35 Anitha D, Baum T, Kirschke JS, Subburaj K. Risk of vertebral compression fractures in multiple myeloma patients: a finite-element study. Medicine (Baltimore) 2017; 96 (02) e5825
• 36 Singh DK, Kumar N, Nayak BK. et al. Approach-based techniques of CT-guided percutaneous vertebral biopsy. Diagn Interv Radiol 2020; 26 (02) 143-146
• 37 Sozzi C, Trentadue M, Nicolì L, Tavani F, Piovan E. Utility of vertebral biopsy before vertebroplasty in patients with diagnosis of vertebral compression fracture. Radiol Med (Torino) 2021; 126 (07) 956-962
• 38 Osterhoff G, Scheyerer MJ, Spiegl UJA, Schnake KJ. The role of routine transpedicular biopsies during kyphoplasty or vertebroplasty for vertebral compression fractures in the detection of malignant diseases: a systematic review. Arch Orthop Trauma Surg 2023; 143 (04) 1887-1893
• 39 Jang HD, Kim EH, Lee JC. et al. Management of osteoporotic vertebral fracture: review update 2022. Asian Spine J 2022; 16 (06) 934-946
• 40 Galibert P, Deramond H, Rosat P, Le Gars D. Preliminary note on the treatment of vertebral angioma by percutaneous acrylic vertebroplasty. [in French]. Neurochirurgie 1987; 33 (02) 166-168
• 41 Clark W, Bird P, Gonski P. et al. Safety and efficacy of vertebroplasty for acute painful osteoporotic fractures (VAPOUR): a multicentre, randomised, double-blind, placebo-controlled trial. Lancet 2016; 388 (10052): 1408-1416
• 42 Guarnieri G, Masala S, Muto M. Update of vertebral cementoplasty in porotic patients. Interv Neuroradiol 2015; 21 (03) 372-380
• 43 Hide IG, Gangi A. Percutaneous vertebroplasty: history, technique and current perspectives. Clin Radiol 2004; 59 (06) 461-467
• 44 Muto M, Muto E, Izzo R, Diano AA, Lavanga A, Di Furia U. Vertebroplasty in the treatment of back pain. Radiol Med (Torino) 2005; 109 (03) 208-219
• 45 Yimin Y, Zhiwei R, Wei M, Jha R. Current status of percutaneous vertebroplasty and percutaneous kyphoplasty—a review. Med Sci Monit 2013; 19: 826-836
• 46 Dohm M, Black CM, Dacre A, Tillman JB, Fueredi G. KAVIAR investigators. A randomized trial comparing balloon kyphoplasty and vertebroplasty for vertebral compression fractures due to osteoporosis. AJNR Am J Neuroradiol 2014; 35 (12) 2227-2236
• 47 Gu CN, Brinjikji W, Evans AJ, Murad MH, Kallmes DF. Outcomes of vertebroplasty compared with kyphoplasty: a systematic review and meta-analysis. J Neurointerv Surg 2016; 8 (06) 636-642
• 48 Chandra RV, Maingard J, Asadi H. et al. Vertebroplasty and kyphoplasty for osteoporotic vertebral fractures: what are the latest data?. AJNR Am J Neuroradiol 2018; 39 (05) 798-806
• 49 Belkoff SM, Mathis JM, Jasper LE, Deramond H. The biomechanics of vertebroplasty. The effect of cement volume on mechanical behavior. Spine 2001; 26 (14) 1537-1541
• 50 Kobayashi N, Noguchi T, Kobayashi D. et al. Safety and efficacy of percutaneous vertebroplasty for osteoporotic vertebral compression fractures: a multicenter retrospective study in Japan. Interv Radiol (Higashimatsuyama) 2021; 6 (02) 21-28
• 51 Marcia S, Muto M, Hirsch JA. et al. What is the role of vertebral augmentation for osteoporotic fractures? A review of the recent literature. Neuroradiology 2018; 60 (08) 777-783
• 52 Fürstenberg CH, Grieser T, Wiedenhöfer B, Gerner HJ, Putz CM. The role of kyphoplasty in the management of osteogenesis imperfecta: risk or benefit?. Eur Spine J 2010; 19 (Suppl. 02) S144-S148
• 53 Rami PM, McGraw JK, Heatwole EV, Boorstein JM. Percutaneous vertebroplasty in the treatment of vertebral body compression fracture secondary to osteogenesis imperfecta. Skeletal Radiol 2002; 31 (03) 162-165
• 54 Pedicelli A, Papacci F, Leone A. et al. Vertebroplasty for symptomatic monostotic Paget disease. J Vasc Interv Radiol 2011; 22 (03) 400-403
• 55 Eckert M, Volmerg JS, Friedrich CM. Augmented reality in medicine: systematic and bibliographic review. JMIR Mhealth Uhealth 2019; 7 (04) e10967
• 56 Auloge P, Cazzato RL, Ramamurthy N. et al. Augmented reality and artificial intelligence-based navigation during percutaneous vertebroplasty: a pilot randomised clinical trial. Eur Spine J 2020; 29 (07) 1580-1589
• 57 Albano D, Messina C, Gitto S, Chianca V, Sconfienza LM. Bone biopsies guided by augmented reality: a pilot study. Eur Radiol Exp 2023; 7 (01) 40
• 58 Li W, Wang J, Liu W. et al. Machine learning applications for the prediction of bone cement leakage in percutaneous vertebroplasty. Front Public Health 2021; 9: 812023
• 59 Muto M, Marcia S, Guarnieri G, Pereira V. Assisted techniques for vertebral cementoplasty: why should we do it?. Eur J Radiol 2015; 84 (05) 783-788
• 60 Manz D, Georgy M, Beall DP, Baroud G, Georgy BA, Muto M. Vertebral augmentation with spinal implants: third-generation vertebroplasty. Neuroradiology 2020; 62 (12) 1607-1615