Evaluation of the impact of a diet rich in omega-3, limited omega-6, and exclusion of acetylsalicylic acid on sinonasal symptoms in patients with CRSwNP and AERD

Topicality CRSwNP with AERD is diagnosed by chronic inflammation signs and worsened respiratory symptoms due to NSAID intake. Treatment challenges include frequent exacerbations and multiple surgeries. Leukotriene-modifying pharmacotherapy is effective, suggesting a role for arachidonic acid interventions. Dietary modifications, affecting fatty acid metabolism and leukotriene production, were explored.

Objective To assess the impact of a diet rich in omega-3, limited omega-6, and exclusion of acetylsalicylic acid on sinonasal symptoms in chronic polypoid rhinosinusitis patients with NSAID intolerance.

Materials and Methods SNOT-22 surveys were conducted on 20 CRSwNP with AERD patients pre and post a 2-week dietary correction. Patients adhered to specific omega-3 and omega-6 intake limits and avoided acetylsalicylic acid, alongside continued corticosteroid treatment.

Results Post-treatment, SNOT-22 scores decreased significantly (49.95 to 36.75). Correlation analysis indicated a positive linear relationship (Pearson R=0.329, p<0.05) between pre and post-diet SNOT-22 scores.

Conclusions A diet rich in omega-3, limited omega-6, and no acetylsalicylic acid positively affected sinonasal symptoms in patients. Results suggest dietary modifications could be a valuable addition to treating CRSwNP with AERD and warrant further investigation.

Publikationsverlauf

Artikel online veröffentlicht:
19. April 2024