Drug Res (Stuttg) 2018; 68(07): 410-414
DOI: 10.1055/s-0044-102093
Original Article
© Georg Thieme Verlag KG Stuttgart · New York

Effects of Risperidone and Aripiprazole on Serum Levels of Prolactin, Testosterone and Estradiol in Female Patients with Schizophrenia

Xiao-Jia Jiang*
1   The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China
2   Shenzhen Bao’an Traditional Chinese Medicine Hospital Group, Shenzhen,China
,
Fu-Xi Wu*
1   The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China
,
Jian-Ping Zhang
3   Department of Pharmacy,Jinan University, Guangzhou, China
,
Lei Shi
4   Department of Pharmacy, General Hospital of Guangzhou Military Command of PLA, Guangzhou, China
,
Jin-Qing Hu
1   The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China
,
Hai-Zhen Zhu
1   The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China
,
Bing Xiao
1   The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China
,
Wei-Cheng Lin
1   The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China
,
Yu-Guan Wen
1   The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China
,
De-Wei Shang
1   The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China
› Institutsangaben
Weitere Informationen

Publikationsverlauf

received 24. August 2017

accepted 27. Januar 2018

Publikationsdatum:
26. Februar 2018 (online)

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Abstract

Objective To evaluate the effects of treatment with risperidone and aripiprazole on serum prolactin, testosterone and estradiol levels in female patients with schizophrenia in China.

Methods In the retrospective study, Data were collected and included prolactin, testosterone and estradiol levels of 30 female patients with risperidone monotherapy. In the prospective study, Another 30 female schizophrenic patients were randomized to receive risperidone or adjunctive aripiprazole for six weeks. Serum prolactin, testosterone and estradiol levels were measured.

Results Serum prolactin, testosterone and estradiol levels in both studies were significantly decreased after risperidone treatment compared with baseline (P<0.05), and prolactin levels remained at a high level. Serum prolactin levels in the adjunctive aripiprazole group were significantly decreased after treatment compared with baseline in the prospective study (P<0.05). Doses of 5 mg and 10 mg of adjunctive aripiprazole achieved the same efficacy at the end of treatment.

Conclusions Risperidone treatment decreased serum testosterone and estradiol levels. Adjunctive aripiprazole relieved hyperprolactinemia, but had no effect on testosterone or estradiol levels. Adjunctive aripiprazole at a dose of 5 mg is recommended for clinical use.

* These authors contributed equally to this paper.