A conservative approach to the treatment of a rare case of cervical spine double expressor diffuse large B-cell lymphoma: a case report
|
2022
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10.7759/cureus.21208
|
Chen W, Hika B, Smith CJ, Parrett TJ, Mesfin FB
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58/M
|
1 y
|
Chronic neck pain and spasm
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Diffuse large B-cell lymphoma
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Retropharyngeal mass extending through the bilateral neuroforamina, into the epidural space, and involving the posterior elements of the cervical spine at C2–C3 (1.8 × 4.7 × 4.5 cm)
|
Posterior decompression and excisional biopsy without resection of the tumor, CT (systemic and intrathecal), RT
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Double expressor DLBCL with anaplastic features. Small lymphocytes and large atypical cells with prominent nucleoli and large cytoplasm, positive for CD20, cyclin D1, and Pax5. Ki67 revealed a substantial level of proliferative activity
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Not available
|
Alive
|
Detection of circulating tumor DNA in cerebrospinal fluid prior to diagnosis of spinal cord lymphoma by flow cytometric and cytologic analyses
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2022
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10.1007/s00277-021-04686-7
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Iriyama C, Murate K, Iba S, Okamoto A, Yamamoto H, Kanbara A, Sato A, Iwata E, Yamada R, Okamoto M, Watanabe H, Mutoh T, Tomita A
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62/M
|
1 mo
|
Motor/sensory disturbance of the extremities
|
Central nervous system lymphoma
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C5–C7 and Th2–Th3 level
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CT (Systemic and intrathecal), RT
|
Not available
|
Not available
|
Alive
|
A rare entity in the lumbar epidural region: T-cell lymphoblastic lymphoma
|
2021
|
10.14444/7165
|
Erdem MB, Kale A, Yaman ME, Emmez H
|
38/M
|
1 mo
|
Weakness in the lower extremities and newly developed urinary incontinence
|
T-lymphoblastic lymphoma
|
L2–L4 levels
|
L3 total, and L2 and L4 bilateral partial decompressive laminectomies, CT, donor lymphocyte
|
Lymphoblastic cell infiltration in the bone marrow biopsy, positive for cytoplasmic CD3 expression and TdT
|
5 mo
|
Deceased
|
Primary cauda equina T-cell lymphoblastic lymphoma
|
2020
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10.1016/j.wneu.2020.06.184
|
De Vries J, Oterdoom MD, Den Dunnen WF, Enting RH, Kloet RW, Roeloffzen WW, Jeltema HR
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54/F
|
8 mo
|
Progressive back pain radiating to both legs and deteriorating neurologic deficits
|
Primary cauda equina TLBL (T-cell lymphoblastic lymphoma)
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L1–L4 and a central mass at L3–L4
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Laminectomy of L3 and L4, Corticosteroids, CT (intrathecal and venous), RT
|
Small blue round tumor cells in hematoxylin and eosin staining. Microscopic analysis showed a vague, nodular growth pattern. The tumor cells were polymorphic and had hyperchromatic nuclei and a nucleolus in some cells. There was hardly any cytoplasm. Multiple mitotic figures were spotted as well as small, thin-walled vessels. Focal points of necrosis were apparent. The lesion mainly consisted of CD-3-positive cells. Further analysis showed positive results for TdT (terminal deoxynucleotidyl transferase) and for the following clusters of differentiation (CD): CD-1a, CD-99, CD-4, and CD-8. Weakly positive were T-cell markers CD-2, CD-5, and CD-7. The lesion showed a Ki-67 proliferation fraction of 90%. EBV in situ hybridization came out negative. These findings are compatible with T-LBL
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6 wk
|
Deceased
|
Primary central nervous system lymphoma mimicking longitudinally extensive transverse myelitis
|
2020
|
10.1177/1941874420967560
|
Natteru PA, Shekhar S, Nair LR, Uschmann H
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59/W
|
4 wk
|
Progressive tetraparesis and bowel and bladder incontinence
|
Large B-cell lymphoma
|
T1–T9 levels
|
CT, Corticosteroids
|
Immunohistochemical staining and flow cytometric analysis was positive for CD-20, BCL-6, and MUM-1, and negative for CD-10 and cyclin D1
|
Not available
|
Alive
|
A rare case of primary ventricular lymphoma presented on FDG PET/CT
|
2020
|
10.1097/RLU.0000000000002876
|
Wang D, Su M, Xiao J
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51/W
|
4 mo
|
Unsteady gait and progressive decline in memory
|
Diffuse large B-cell lymphoma
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Multiple space-occupying lesions in the ventricles
|
Not available
|
Diffuse growth pattern of large, dysplastic lymphocytes with vesicular nuclei, positive for CD20 and MUM1 immunostaining. Ki67 demonstrated high proliferative index
|
Not available
|
Not available
|
Primary central nervous system lymphoma with diffuse neurolymphomatosis involving multiple cranial and spinal nerve roots
|
2020
|
10.1097/RLU.0000000000003018
|
Singh SS, Mittal BR, Kumar R, Singh H, Balaini N, Goyal M
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23/M
|
4 mo
|
Intermittent fever, headache, vomiting, loss of weight and appetite, and progressive weakness of all 4 limbs, which subsequently progressed to quadriplegia associated with urinary incontinence. Evolved with altered sensorium, decreased hearing in both ears, decreased sensation in bilateral upper and lower limbs and trunk, difficulty in swallowing, change in voice, and nasal regurgitation
|
B-cell non-Hodgkin's lymphoma
|
Brainstem, cerebellum, spinal cord, cribriform plate, bilateral foramen ovale and foramen rotundum, multiple spinal nerve roots, lateral ventricles, bilateral jugular foramen and carotid canal, bilateral Meckel's cave
|
Antitubercular therapy, Corticosteroids,
|
High-grade B-cell non-Hodgkin's lymphoma
|
Not available
|
Not available
|
Primary diffuse large B-Cell non-Hodgkin's lymphoma of the thoracic spine presented initially as an epigastric pain
|
2020
|
10.4103/ajns.AJNS_300_19
|
Fakhouri F, Shoumal N, Obeid B, Alkhoder A
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60/M
|
4 days
|
Acute nonradiating epigastric pain. Two days later, the pain started to radiate toward the back, and the patient started to suffer from severe thoracic back pain. Four days later, the pain started to radiate toward both lower limbs with subtle beginning of the weakness of the lower limbs and progressed within a few hours later to inability to walk, with intact neurological function of the upper extremities
|
Large B-cell lymphoma
|
T6/T7 level
|
Partial laminectomy with total resection of the extradural mass, CT
|
Diffuse malignant infiltration of large atypical lymphoid cells, large vesicular nuclei, prominent nucleoli, and coarse chromatin. Numerous mitotic cells were also present, and immune stains were positive for CD20 and leukocyte common antigen
|
2 y
|
Alive, free of infection
|
Hematolymphoid malignancies presenting with spinal epidural mass and spinal cord compression: a case series with rare entities
|
2019
|
Not available
|
Pandey S, Gokden M, Kazemi NJ, Post GR
|
61/M
|
3 wk
|
Lower back and leg pain, numbness, inability to walk, and bladder/bowel incontinence
|
Diffuse large B-cell lymphoma, not otherwise specified
|
L1 mass with extension from T12 to L3 with cord compression
|
Tumor resection
|
Large neoplastic cells with prominent eosinophilic cytoplasm, irregular nuclei, and frequent mitoses, with scattered eosinophils
|
Lost to follow-up
|
Not available
|
49/M
|
2 wk
|
New back pain, left leg weakness, and numbness
|
Diffuse large B-cell lymphoma, not otherwise specified
|
L2 vertebral body pathologic fracture and a left paraspinal mass involving the kidney, psoas muscle aorta and L1–L3 vertebrae
|
Tumor resection, CT
|
Large neoplastic cells with prominent eosinophilic cytoplasm, irregular nuclei, and frequent mitoses, with scattered eosinophils
|
2 wk
|
Alive with disease
|
23/M
|
1 mo
|
Progressive back pain and difficulty walking
|
Diffuse large B-cell lymphoma, not otherwise specified
|
T7–T8 vertebral body mass with epidural extension at T6–T9
|
Tumor resection, CT
|
Large neoplastic cells with prominent eosinophilic cytoplasm, irregular nuclei, and frequent mitoses, with scattered eosinophils
|
Not available
|
Alive, free of infection
|
55/F
|
3 mo
|
Mid-back pain (3 mo), bilateral lower extremity weakness (2 wk), and complete sensorimotor loss (2 d)
|
Anaplastic large cell lymphoma
|
T4 vertebral mass with T3–T5 soft-tissue component and cord compression. Additional lesions in T12 vertebra, left ilium, right femur, bilateral pleural effusions, multiple lung nodules, and left frontal extra-axial mass
|
Tumor resection, CT
|
Pleomorphic population of highly atypical cells with eosinophil polymorphonuclear leukocytes; positive for CD45, CD5, and CD30
|
4 y
|
Alive, in remission
|
15/M
|
1 mo
|
Back pain, tingling, and numbness of legs
|
B-lymphoblastic lymphoma
|
T9 vertebral body mass with epidural extension at T8–T10
|
Tumor resection, CT
|
Not available
|
Not available
|
Alive, free of infection
|
Primary intraspinal non-Hodgkin's lymphoma: case report and review of literature
|
2019
|
10.1016/j.jocn.2018.11.046
|
Beume LA, Wolf K, Urbach H, Klingler JH, Staszewski O, Marks R, Weiller C, Rauer S, Hosp JA
|
67/F
|
6 wk
|
Inability to walk, reduced sensitivity in the lower extremities, and bowel and bladder dysfunction. Severe weakness of the right (MRC muscle scale: 1/5) and left leg (2/5), and loss of sensation below Th6. Deep tendon reflexes of the legs were absent while Babinski's sign was positive on both sides
|
Primary intraspinal B-cell non-Hodgkin's lymphoma
|
Upper border of C6: upper border of T12. Intramedullary T3–T9. Retinal infiltration
|
CT/BT
|
Pleomorphic partially lymphoid, partially blastic tumor cells with increased mitotic and proliferative activity and immunohistochemical positivity for CD20 and CD79a, with a MIB1 of 90%
|
Not available
|
Alive
|
Primary peripheral gamma delta T-cell lymphoma of the central nervous system: report of a the intramedullary spinal cord and presenting with myelopathy
|
2019
|
10.4132/jptm.2018.08.21
|
Yim J, Song SG, Kim S, Choi JW, Lee KC, Bae JM, Jeon YK
|
75/W
|
3.5 mo
|
Back pain and lower extremity weakness
|
Primary peripheral gamma-delta T-cell lymphoma
|
Multiple enhancing intramedullary nodular lesions in the spinal cord at T9–T10, T11, and L5 levels
|
T11 laminectomy and tumor removal
|
Diffuse infiltration of monotonous, medium-to-large atypical lymphocytes with round nuclei, condensed chromatin, pale-to-eosinophilic cytoplasm, and small inconspicuous nucleoli. Immunohistochemically, the atypical cells were CD3(+), CD20(–), TCRßF1(–), TCRγ(+), CD30(–), CD4(–), CD8(–), CD10(–), BCL-6(–), MUM1(–), CD56(+), TIA-1(+), granzyme B(focal +), and CD103(+). The Ki-67 index was about 80%
|
Lost to follow-up
|
Not available
|
Spinal primary central nervous system lymphoma: case report and literature review
|
2018
|
10.1016/j.jocn.2018.01.034
|
Li Feng, Dingbang Chen, Hongyan Zhou, Cunzhou Shen, Haiyan Wang, Xunsha Sun, Xiulin Liang, Ling Chen
|
45/M
|
1 y
|
Progressive tremor in the left limbs and slight dysarthria as well as 3-mo history of paraparesis, tinnitus, and insomnia. Severe dysarthria, sialorrhea, incompetent closure of the eyelids, constipation, atrophy in the left limbs, as well as paralysis and numbness in the left lower limb in 2 mo
|
Spinal primary central nervous system lymphoma
|
Cerebellum and cauda equine
|
First tuberculosis was suspected, treatment with isoniazid, rifampicin, pyrazinamide, and ethambutol was performed, in addition to intrathecal injections of isoniazid and dexamethasone
|
Cytological examination of CSF revealed abundant of lymphocytes with macronucleoli
|
2 wk
|
Deceased
|
Primary spinal lymphoma masquerading as meningioma: preoperative and postoperative magnetic resonance imaging findings
|
2018
|
10.1016/j.wneu.2018.04.129
|
Arslan H, Yavuz A, Aycan A
|
55/M
|
Not available
|
Back pains with the complaints accompanied by increasing weakness in the lower extremities
|
Diffuse large B-cell non-Hodgkin's lymphoma
|
Thoracic area, the anterior epidural space and paravertebral area, approximately 55 × 9 mm
|
Tumor removal
|
Diffuse large B-cell non-Hodgkin's lymphoma
|
Not available
|
Not available
|
A case report of primary central nervous system lymphoma with intestinal obstruction as the initial symptom
|
2018
|
10.1097/MD.0000000000010080
|
Li X, Qi S, Jiao Y, Gao J, Du H
|
50/M
|
8 d
|
Lack of defecation for 8 d and with symptoms of abdominal distention, intermittently suffered from backache
|
Diffuse large B-cell lymphoma
|
Right of centrums of T9–T11
|
Tumor removal, CT
|
Immunohistochemical analyses showed the following: AE1/AE3 (–), Bcl-2 (–), Bcl-6 (+), CD10 (–), CD20 (+), CD3 (marginally +), CD30 (Ki-1) (–), CD31 (–), CD34 (–), CD5 (marginally +), HMB45 (–), Ki-67 (index; 40%), Mum-1 (–), and PAX-5 (+)
|
Lost to follow-up
|
Alive
|
Primary cauda equina lymphoma diagnosed by nerve biopsy: a case report and literature review
|
2018
|
10.3892/ol.2018.8629
|
Suzuki K, Yasuda T, Hiraiwa T, Kanamori M, Kimura T, Kawaguchi Y
|
65/M
|
5 mo
|
Gait disturbance due to motor palsy in the bilateral lower extremities, and severe numbness in his left sole
|
Diffuse large B-cell lymphoma, nongerminal center type
|
L1–S1
|
Cauda equina biopsy, CT (intravenous)
|
Atypical cells with irregular large nuclei and little cytoplasm had infiltrated into the nerve, positive for cluster of differentiation (CD)20, B-cell lymphoma 2 (BCL-2), BCL-6, multiple myeloma oncogene 1 (MUM-1), and negative for CD3, CD5, and CD10
|
6 y
|
Alive, free of infection
|
Wrap-around appearance: underrecognized radiologic feature of spinal lymphoma
|
2018
|
10.1016/j.wneu.2018.04.051
|
Patel M, Wu OC, Kasliwal MK
|
71/M
|
Not available
|
Neck and upper back pain
|
Non-Hodgkin's lymphoma
|
T2
|
T2 laminectomy and decompression, CT
|
Not available
|
Not available
|
Not available
|
Primary central nervous system lymphoma of T-cell origin: an unusual cause of spinal cord disease
|
2017
|
10.1007/s13760-016-0726-y
|
Sophie Fastré, Frédéric London, Julie Lelotte, Alessandra Camboni, Anne Jeanjean
|
45/M
|
Over weeks
|
Progressive paraparesis and numbness of his lower limbs over weeks, with bladder dysfunction. Generalized hyperreflexia and bilateral extensor plantar response
|
Lymphoma of T-cell origin
|
Hypersignal images in the left cerebellum and intramedullary cervical spinal cord with rostral extension to the brainstem
|
Corticosteroids, CT
|
Infiltration of cerebellar tissue with histiocytes and lymphocytes. Lymphoma of T-cell origin (strongly positive for CD3, CD2, CD5, and CD4, and weakly positive for CD7)
|
3 mo
|
Alive
|
Non-Hodgkin lymphoma of the cauda equina: a rare entity
|
2017
|
10.1080/02688697.2016.1224321
|
Geevarghese R, Marcus R, Aizpurua M, Al-Sarraj S, Ashkan K
|
46/M
|
3 mo
|
Gradually worsening lower back pain, radiating to both legs (worse on the right) accompanied with paresthesia over the genital areas, lack of sensation on passing urine and stools
|
Follicular grade I–II lymphoma
|
L4/L5 to the mid-S2 level
|
L4–S1 decompression and debulking, corticosteroids, CT, IMB
|
Positive for CD20 and a low proliferative index (Ki67; 10%)
|
2.5 y
|
Alive, free of infection
|
Primary spinal marginal zone lymphoma: an unusual cause of spinal cord compression
|
2017
|
10.11604/pamj.2017.27.171.11947
|
Alaya Z, Achour B
|
67/M
|
2 mo
|
Progressive paralysis, concerned with the lower limbs
|
Marginal zone lymphoma
|
Extensive posterior epidural tissue process fromT6 to T8 in continuity with left pleural neoplastic thickening through the intervertebral homolateral foramens
|
Laminectomy with resection of the intra-ductal lesion, CT
|
Heterogeneous group of B-cell lymphomas derived from marginal zone cells found in the spleen's white pulp and surrounding germinal centers
|
Not available
|
Alive, free of infection
|
Primary intramedullary malignant lymphoma in the cervical cord with a presyrinx state
|
2017
|
10.7759/cureus.2006
|
Chida K, Sugawara A, Koji T, Beppu T, Mue Y, Sugai T, Ogasawara K
|
79/M
|
6 mo
|
Left hemiparesis with 2/5 in his upper limb and 3/5 in his lower limb and hypoesthesia in his left side from the neck to the foot. The deep tendon reflexes were increased in his left upper limb
|
Diffuse large B-cell lymphoma
|
C1–C2
|
Tumor removal
|
Diffuse proliferation of large atypical lymphocytes, positive for CD20 and CD79a, and negative for CD3
|
2 y
|
Alive
|
Primary spinal epidural lymphoma as a cause of spontaneous spinal anterior syndrome: a case report and literature review
|
2017
|
10.1055/s-0036-1597692
|
Córdoba-Mosqueda ME, Guerra-Mora JR, Sánchez-Silva MC, Vicuña-González RM, Torre AI
|
45/M
|
2 mo
|
High-intensity thoracic pain limiting his movements; a month later, he was accompanied by decrease in the strength of the left pelvic limb; after 2 mo, he started with weakness of both lower limbs and impaired urinary sphincter control
|
Diffuse large B-cell lymphoma
|
T1–T2
|
Neural decompression by posterior way and biopsy of the extradural spinal lesion, CT, RT
|
CD20þ, BCL-2þ, CD3þ CD5þ, CD10þ, CD30–, and Ki67 positive in 20% of neoplastic cells
|
Not available
|
Not available
|