Laryngorhinootologie 2023; 102(S 02): S330
DOI: 10.1055/s-0043-1767573
Abstracts | DGHNOKHC
Rhinology: Nasal cavity/Paranasal sinuses

Diagnostic Imaging of Sinonasal Cavity Changes in Granulomatosis with Polyangiitis

Taniel Minkov
1   University Hospital Kaspela, Clinic of ENT
,
Katya Doykova
2   Medical Faculty, Medical University of Plovdiv, Department of Diagnostic Imaging
3   University Hospital Kaspela, Department of Diagnostic Imaging
,
Dimitar Pazardzhikliev
1   University Hospital Kaspela, Clinic of ENT
4   Medical Faculty, Medical University of Plovdiv, Department of Otolaryngology
,
Dilyana Vicheva
1   University Hospital Kaspela, Clinic of ENT
4   Medical Faculty, Medical University of Plovdiv, Department of Otolaryngology
,
Ilian Doykov
1   University Hospital Kaspela, Clinic of ENT
4   Medical Faculty, Medical University of Plovdiv, Department of Otolaryngology
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    Granulomatosis with polyangiitis (GPA, Wegener’s granulomatosis) is a rare autoimmune disorder that causes necrotizing vasculitis of small veins and arteries with a predilection for the respiratory system and kidneys. Classic GPA includes a triad of necrotizing granuloma of the upper and lower respiratory system, systemic vasculitis, and necrotizing glomerulonephritis. However, GPA can begin with limited organ involvement and any system can be affected. Head and neck region involvement is seen in up to 85% of cases and the sinonasal cavity is the most frequently involved. Earliest symptoms are often non-specific and include nasal obstruction, epistaxis, facial pain or pressure, and reduction or loss of smell, making GPA misdiagnosed as chronic rhinosinusitis. We describe two cases of GPA presenting with subacute rhinosinusitis refractory to long-term outpatient treatment.

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    Conflict of Interest

    The authors declare that they have no conflict of interest.

    Publication History

    Article published online:
    12 May 2023

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