Results
Historical Note
Gastrointestinal-related emergencies are among the earliest reports in the medical
literature on the health aspects of RF that can be traced in PubMed.[4]
[5]
[6] Greater incidence of perforated peptic ulcers in Ramadan was reported by Leca and
Fortesa from Algeria in 1954.[4] Furthermore, the significance of the frequency of perforated ulcers during Ramadan
from Morocco by Lahbabi in 1957.[5] Also, experience with the effect of RF on the frequency of perforation of gastroduodenal
ulcers among the population of Tunisia was reported by Vach in 1966.[6] Indeed, the symptomatic worsening of peptic disease during Ramadan is well imprinted
in the folk culture in the era preceding the discovery of histamine H2 antagonists.
Diabetic complications came to the scene later.[1]
The burden of EMS during Ramadan
Burden, Distribution, Nature in Order
An important goal for the emergency department (ED) operational management is planning
for changes in patient volume and assuring staffing accordingly. EDs worldwide experience
substantial variability in hourly patient arrivals and change considerably during
holidays, posing challenges to resource allocation. Ramadan is associated with social
and biological changes in a repetitive annual occurrence, which may impact the burden
on emergency services. [Table 2] lists several main studies addressing the impact on burden and pattern of attendance
to EDs, hospitalizations, and admissions to intensive care.[7]
[8]
[9]
[10]
[11]
[12]
[13] The salient findings of these and other studies are discussed below.[7]
[8]
[9]
[10]
[11]
[12]
[13]
[14]
[15]
[16]
[17]
[18]
[19]
[20]
Table 2
The burden and pattern of emergency attendance, acute admissions, and seeking of emergency
services during RF
|
Author, year (Ref)
|
Settings, region
|
Results and conclusions
|
|
Langford et al, 1994[7]
|
A &E, London, UK, 1993
|
There is a significant rise in the number of attendances in total and non-accident-related
attendance but not in accident-related attendance
|
|
Parrilla Ruiz et al, 2003[8]
|
ED, Madrid, Spain, 2001.
|
There is Increase abdominal pain consultation related to fasting followed by large
meals during Ramadan
|
|
Topacoglu et al, 2005[9]
|
ED, Izmir, Turkey (2000–2004)
|
ER visits were significantly higher in Ramadan for hypertension and uncomplicated
headache diabetes-related conditions in Ramadan were significantly younger patients
|
|
Pekdemir et al, 2010[10]
|
ED, Kocaeli, Turkey, 2009
|
The clinical features of patients admitted to the ED and the number of ED admissions
for specific ailments did not change significantly
|
|
Halasa, 2014 [11]
|
ED, Private Hospital, Jordan, 2010
|
Significant increase in late night and early morning ED visits in Ramadan compared
with other months
|
|
Al Assaad et al, 2018[12]
|
ED Tertiary Care Center, Beirut, Lebanon, 3 years
|
Decrease ED volume with longer ED stay and worse outcome during Ramadan
|
|
Balhara et al, 2018[13]
|
ED, Tertiary Hospital, Abu Dhabi, UAE (2010–2013)
|
Decrease ED visits and later peak time after breaking the fast. More GI and trauma
cases.
|
Abbreviations: ED, emergency department; GI, gastrointestinal; RF, Ramadan fasting;
UAE, United Arab Emirates.
One study from Qatar found that Ramadan was not associated with the change in patient
age or the proportion of high-acuity cases. However, it was associated with an increase
in the proportion of male, pediatric, and Qatari national patient visits.[14] These results are similar to those of others who found a significant diurnal variation
in the hourly number of cases. He noted a marked increase in patients in the early
evening, late evening, and early morning hours.[15] However, other groups found a slight reduction in the number of cases presented
during Ramadan. The numbers for patients presented during Ramadan are slightly higher
during fasting hours (53% vs. 47%).[16] Others noted that 60% of patients who presented during Ramadan attended during the
night shift.[17]
Topacoglu et al found that the frequency of visits has stayed the same. However, certain
conditions like diabetes-related complications have more tendency to present during
Ramadan.[9] In a multiethnic community, the proportion of Muslim patients presented to the ED
department was found to be increased during the month of Ramadan.[7] During one study, the increased frequency of Muslim patients was specifically due
to abdominal pain. Observed a small but not significant increase in accident-related
attendance.[8] EDs might experience a decrease in volumes, a longer stay, and potentially worse
outcomes during Ramadan, with no changes to the frequencies of visits related to common
medical conditions.[12]
Whereas the previous results concentrated on ED attendance, others studied patients
admitted to the intensive care unit (ICU) in Tunisia in Shaban, Ramadan, and Shawal.
The percentages of admitted patients with chronic kidney disease (CKD) (2.3, 3.5,
and 7.3%, respectively) and for hypovolemic shock (1.6, 6.1, and 5.0%, respectively)
were significantly higher. While there were no differences in any studied outcomes
in patients admitted to ICU before, during, or after Ramadan, there was a significant
increase in patients presenting with a history of CKD, hypovolemic shock, and inverted
urinary sodium to potassium ratio.[18]
The characteristics of visits to the adult ED between those in 2016, which included
the longest fasting time, and those in the year 2000, which included the shortest
fasting time, were studied in Ankara, Turkey.[19] Patient visits made during Ramadan in the years 2000 and 2016 were included in the
study. There was a statistically significant difference between the total number of
visits to the ED in the Ramadan months of 2000 and 2016 (p < 0.001). Moreover, there was a statistically significant difference in the number
of complaints between Ramadan of 2000 and 2016 (p < 0.001). Also, Halasa found more patients presenting during the night hours than
during daytime hours, echoing previous results; however, he found a larger proportion
of younger patients presented with respiratory tract infections during Ramadan.[11] Finally, Balhara et al[13] examined patients in the United Arab Emirates (UAE) and Sawaya et al[20] examined patients in Lebanon, they both observed a reduction in pediatric patient
group attendance, with Balhara et al noting a decrease in the length of stay in this
group of patients.
Accidents and Injuries
[Table 3] summarizes the different studies in this context that came up with contrasting findings
and conclusions.[21]
[22]
[23]
[24]
[25]
[26] The number of persons injured by traffic accidents was slightly higher during Ramadan
than in other months in Al Ain, UAE. Most of the accidents and injuries occurred from
8.00 a.m. to 2.00 p.m.[21] However, Mehmood et al found that the frequency of road traffic crashes did not
change significantly during Ramadan when studying road traffic data in Karachi in
Pakistan for 2006 and 2011.[22] Furthermore, Akman and Kuru analyzed the causes and outcomes of presentations to
EDs due to injuries from motor vehicle crashes and pedestrian strikes. They found
that motor vehicle crashes did not increase during Ramadan.[24] Also, Khammash and Al-Shouha enrolled all patients with an road traffic accident-related
diagnosis in the ED of Princess Basma Teaching Hospital, Irbid, Jordan, during and
around Ramadan. They found no significant differences between the numbers and severity
of injuries among the subgroups of patients concerning the time of the day or the
weekdays.[26]
Table 3
Patterns and types of accident and injuries during Ramadan fasting
|
Authors (Year)
|
Variables and sample size
|
Settings
|
Findings/Conclusion
|
|
Bener et al, 1992[21]
|
Retrospective study of all 1197 people injured during Ramadan
|
Al Ain Hospital, UAE (1990)
|
Slight increase in RTA injuries during Ramadan
|
|
Mehmood et al, 2015[22]
|
Retrospective analysis of the Road Traffic Injury Surveillance Project (N = 163,022)
|
Karachi, Pakistan (2006–2011)
|
No significant change in RTA during Ramadan. Cluster around breaking the fast and
the Tarawih prayers
|
|
Tahir et al, 2014[23]
|
12,969 RTAs occurred in Ramadan versus a monthly average of 11 573 RTAs
|
Punjab, Pakistan (August, 2011 versus rest of 2011)
|
Significant increase in RTA emergencies during Ramadan compared with other months
|
|
Akman and Kuru, 2020[24]
|
Causes and outcomes of presentations to EDs due to RTA injuries (N = 798)
|
Canakkale Province, Turkiye (2019–2020)
|
RTA did not increase during religious seasons including Ramadan
|
|
Ghumman and Horney, 2016[25]
|
Manual review of death certificates during the heat wave
|
Hospitals and clinics, Karachi, Pakistan (2015)
|
No significant increase in heat-related mortality in a heat wave coinciding with Ramadan
|
|
Khammash and Al-Shouha, 2006[26]
|
228 RTA-related injuries: 96 during RF and 132 during the control period
|
Princess Basma Hospital, Irbid, Jordan (2004)
|
No significant change in the number and type of injury in time of day or weekdays
|
Abbreviations: ED, emergency department; RF, Ramadan fasting; RTA, road traffic accident;
UAE, United Arab Emirates.
Surgical Emergencies
The changing pattern of surgical emergencies during Ramadan was investigated in two
large retrospective cohort studies with contracting conclusions from Turkiye and Kuwait.[27]
[28] The changes in patients' profiles were investigated in the surgical emergency unit
in Ankara Numune Hospital using the intraoperative diagnosis of 1,408 patients who
underwent surgery in the emergency unit between 1999 and 2003, during and after Ramadan.[27] Peptic ulcer perforation and acute mesenteric ischemia significantly increased during
Ramadan compared with the months before and after Ramadan. On the other hand, violence-induced
penetrating injuries like stab wounds and gunshot wounds decreased significantly during
Ramadan. Other surgical interventions did not change.[27] On the contrary, examination of the surgical department of Al-Sabah Hospital, Kuwait,
examined all patients (n = 61,832) who attended the surgical department during three consecutive lunar months
each year (the fasting month - Ramadan, the month before [Shaban], and the month after
[Shawal]), for the five consecutive years.[28] The majority (85%) were Muslims (mixed group). The study was further refined to
analyze Kuwaiti patients who were all Muslims (Muslim group). Primary outcome measure: Attendance at the surgical department attendance in the mixed group was less during
Ramadan and Shawal than during Shaban (p = 0.06). In the mixed group, attendance during Shawal was much less than in Shaban
(p = 0.0007). Patients in the Muslim group attending the surgical department (2000–2004)
showed decreased attendance during Ramadan and Shawal compared with Shaban (p = 0.015). The total number of cases admitted to the hospital through the surgical
department was less in Ramadan and Shawal than in Shaban (p = 0.6). These studies suggest that (1) physiologic and behavioral changes during
Ramadan may alter patient profiles in a surgical emergency unit, and (2) there is
a decrease in the number of Muslim patients attending the surgical department during
the fasting month of Ramadan and Shawal compared with Shaban, possibly indicating
that Muslim fasting may positively decrease the number of patients attending the surgical
department.
Acute Diabetic Emergencies
Attendance to Emergency Services and Hospitalizations
Diabetes-related emergencies are the most common endocrine emergencies encountered
during Ramadan, leading to a surge in diabetes studies during Ramadan. A retrospective
study examined the variation in visits to the ED during Ramadan compared with other
lunar months at a tertiary care hospital in Jeddah city in adults (> 18 years) using
an electronic medical record review of patients with diabetes emergencies who visited
the emergency room (ER) of a military hospital from the 9th to 11th lunar months during
2017 to 2018.[29] The frequency of ER visits, sociodemographic characteristics, and clinical features
were determined. A total of 24,498 admissions were recorded. The prevalence of diabetes
emergency visits was only 0.84%. Based on inclusion criteria, a total of 133 subjects
were included in the study (54.1% men and 45.9% women). Most (73.7%) were on insulin
therapy, and more than half (51.9%) had type 2 diabetes mellitus (T2DM). There was
a significant difference (p = 0.001) in the prevalence of diabetes emergency visits between the three lunar months,
Shaban, Ramadan, and Shawal, 7, 5, and 4%, respectively. However, the highest prevalence
was not during Ramadan. Although some correlations were identified, the study found
no significant differences between the frequency of ER visits and various demographic,
clinical factors, and diabetes profiles between Ramadan and other preceding and succeeding
lunar months. These authors suggested a downward prevalence trend from Shaban to Ramadan
and Shawal. The results suggest that fasting during the month of Ramadan does not
negatively impact diabetes emergencies in comparison with other months. Hyperglycemia
among T2DM and insulin-treated patients were recorded as the highest feature of diabetes
emergency visits during the 3 months studied, with no significant differences between
the months. These findings highlight the need for type 2 and insulin-treated patients
to be thoroughly assessed by primary care physicians, and in-depth health education
and guidance should be given to them.
Additionally, the admissions for diabetes emergencies among 295 patients who fasted
or planned to fast 1 month before (N = 119), during (N = 106), and 1 month after (N = 70) Ramadan of 2019 in public hospitals in Malaysia were investigated.[30] Admissions for hyperglycemic emergencies accounted for two-thirds of admissions.
Thirty-seven percent of admissions for hypoglycemia occurred before Ramadan and 32.1%
during Ramadan. Contributing factors to hypoglycemia included the use of sulphonylurea
(59.6%), the presence of nephropathy (54.5%), and a history of hypoglycemia (45.5%).
Diabetic ketoacidosis (DKA) accounted for more admissions than hyperosmolar hyperglycemic
state (HHS) (119 vs. 77), and the highest proportion occurred during Ramadan (36.1%).
Most of the admissions for hyperglycemic emergencies were among those with T2DM (75.9%
for DKA and 97.4% for HHS). Only 31.5% of patients admitted for diabetes emergencies
recalled having received Ramadan advice in the past. Also, a review of the records
of 402 patients with diabetes admitted to the medical department at Benghazi Medical
Center, Libya, during Ramadan and Dhu al-Qidah of 2016 was conducted.[31] The differences in reasons for admission, length of stay, and in-hospital mortality
were compared between patients admitted during Ramadan and Dhu al-Qidah and between
patients who were fasting at the time of admission during Ramadan and those who were
not. During Ramadan, 186 patients were admitted compared with 216 during Dhu al-Qidah.
There was no significant difference in reasons for admission, length of hospital stay,
or in-hospital mortality (borderline for mortality, p = 0.078) between patients with diabetes admitted during Ramadan and Dhu al-Qidah.
Similar to the previous study from Saudi Arabia.[29] Of those admitted in Ramadan, 59.1% were fasting on admission. Fasting patients
admitted during Ramadan had a significantly higher proportion of diseases of the circulatory
system when compared with nonfasting patients (39.4% vs. 23.6%, p = 0.028). In comparison, in-hospital mortality was higher in nonfasting patients
(29.2% vs. 8.7%, p < 0.001). There was no significant difference in length of stay between fasting and
nonfasting patients.
Severe Hypoglycemia
The risk of hypoglycemia in patients with diabetes fasting during Ramadan has improved
over the years. The first study to highlight the incidence of hypoglycemia in fasting
patients with diabetes was the landmark EPIDIAR study.[32] It was a population-based, retrospective transversal survey conducted in 13 countries.
A total of 12,914 patients with diabetes were recruited using a stratified sampling
method, and 12,243 were considered for the analysis. During Ramadan, 42.8% of patients
with T1DM and 78.7% with T2DM fasted for at least 15 days. Severe hypoglycemic episodes
were significantly more frequent during Ramadan than in other months (T1DM, 0.14 vs.
0.03 episode/month, p = 0.0174; T2DM, 0.03 vs. 0.004 episode/month, p < 0.0001). More recently, a real-world survey studied the risk of hypoglycemia during
Ramadan, its risk factors, and the impact of hypoglycemia on patients' behavior in
a cross-sectional multicountry observational study, with data captured within 6 weeks
after Ramadan 2015. In a cohort of 1,759 patients, hypoglycemia was reported by 290
patients (16.8%), mainly affecting insulin-treated patients in general.[33] Fasting was interrupted by 67% of those who experienced hypoglycemia, and recourse
to emergency services was pursued by less than a quarter of patients with hypoglycemia.
Another comparison of the incidence of symptomatic hypoglycemia in fasting Muslim
patients with T2DM treated with sitagliptin (n = 507) or a sulphonylurea (n = 514) during Ramadan.[34] However, there were no reported events that required medical assistance or were
considered severe (i.e., events that caused loss of consciousness, seizure, coma,
or physical injury) during Ramadan. Similar findings of low hypoglycemia risk are
seen within the pediatric population; the safety of Ramadan was evaluated among 50
children and adolescents with T1DM, age 12.7 years. Twenty-seven patients (54%) were
on multiple daily injections (MDIs) insulin regimens, and 23 (46%) were on insulin
pump therapy.[35] Participants were compared according to the insulin treatment regimen and their
glycemic control level before Ramadan. The children could fast for 20 days of Ramadan,
and the most common cause for breaking the fast was mild hypoglycemia (7.8% among
all cases). There was no significant difference between the two insulin regimen groups
in breaking fast days, frequency of hypo- or hyperglycemia, weight, and hemoglobin
A1c (HbA1c) changes post-Ramadan. Patients with HbA1c ≤ 8.5% were able to fast more
during Ramadan with significantly less-frequent hypoglycemic attacks than patients
with HbA1c > 8.5 (1.2 vs. 3.3 days of hypoglycemia, p = 0.01, respectively).
Severe Hyperglycemia
To determine the burden of severe hyperglycemia-related admissions in diabetes patients
fasting during Ramadan, a retrospective chart review was conducted that included all
Muslims admitted with DKA in Abu Dhabi, UAE, over 10 years (2005–2014).[36] There were 432 episodes of DKA involving 283 patients. Of these, 370 episodes (85.6%)
involved 231 patients (81.6%) with type 1 diabetes. The number of admission episodes
was not different during Ramadan from the average calendar month (3.6 episodes/month
vs. 3.3 episodes/month, respectively, p = 0.77). No recurrences of admissions were observed during Ramadan. Some other observed
seasonality trends were not related to Ramadan. On the contrary, a retrospective study
of all adults admitted with DKA explored the relationship of admissions to Ramadan
by comparing it to the month before (Shaban) and the month after (Shawal) and found
different results.[37] Fifty-one patients with DKA were admitted; 19 in Ramadan (37.3%), 8 in Shaban (15.7%),
and 24 in Shawal (47%), showing a significant increment in Ramadan compared with Shaban
and a higher increment in Shawal (p = 0.019). The most common precipitating factor for DKA during Ramadan and Shaban
is missing insulin doses, while infections are considered the main stimulating agent
in Shawal. However, a critical reappraisal of the literature up to 2019 concluded
that the state of knowledge and evidence suggests that the risk of DKA is not increased
during RF.[38] It was supported by findings from a prospective evaluation of patients with diabetes
wishing to fast during Ramadan, excluding patients considered at very high risk. In
this cohort, no patient reported significant hyperglycemia, ketosis, or severe hypoglycemia.[39]
Over the last few years, technology has reshaped the outcomes of patients with diabetes.
This is also evident in the context of Ramadan. A systematic review and meta-analysis
addressed the role of technology in the safety of RF in young patients with T1DM.[40] Pooled data from 17 observational studies involving 1,699 patients treated with
either continuous subcutaneous insulin infusion (CSII) or non-CSII (including premixed
and MDI) regimens. The CSII-treated group (n = 203) was older (22.9 vs. 17.8 years) and had longer diabetes duration (116.7 vs.
74.8 months) and lower glycated hemoglobin (7.8% vs. 9.1%) at baseline than the non-CSII-treated
group (n = 1,496). The non-CSII-treated group had less nonsevere hypoglycemia than the CSII-treated
group (22% vs. 35%). The CSII regimen had lower rates of severe hypoglycemia and hyperglycemia/ketosis.
However, a higher rate of nonsevere hyperglycemia than premixed/MDI regimens suggesting
appropriate patient selection with regular supervised fine-tuning of the basal insulin
rate with intensive glucose monitoring might mitigate the residual hypoglycemia risk
during Ramadan.
Adrenal Crisis
Adrenal replacement therapy is conventionally given at set times of the day. Therefore,
although the conventional drug is hydrocortisone, its biological half-life is too
short to cover the long fasting hours. RF may disturb the replacement routine. Some
earlier authors categorized adrenal crisis as high risk and naturally advised to avoid
fasting.[41] To avoid this, they recommended longer-acting glucocorticoids, such as prednisolone
at Suhoor time and hydrocortisone in the evening, taken at Iftar time. The dose of
prednisolone is based on the usual morning hydrocortisone dose. The mineralocorticoid
dose should be taken in primary adrenal insufficiency (AI) at Suhoor time. Patients
should be educated regarding the acute illness rules and should have contact details
and access to return to the clinic if needed. Maintaining hydration and mineral balance
and avoiding exhausting exercise, particularly in hot weather, are obvious precautions
for patients on adrenal replacement therapy.[41] However, a cross-sectional study of approximately 180 patients with known and treated
adrenal insufficiency was undertaken to create a more evidence base.[42] A 14-item questionnaire concerning patients' knowledge about the disease and fasting
during Ramadan was used. One hundred thirty-eight patients (76.7%) received advice
from their physician not to fast, and 91 patients (50.5%) tried to fast. Complications
occurred in 67.0%, including asthenia in 88.5% of cases, intense thirst in 32.8%,
symptoms of dehydration in 49.2%, and symptoms of hypoglycemia in 18%. More recently,
a U.K.-based group proposed detailed risk stratification for patients with AI and
optimal management strategies.[43] They suggested that patients with AI wishing to fast should undergo a thorough risk
assessment, ideally several months before Ramadan. “High-risk” and “very high-risk”
patients should be encouraged to explore alternative options to fasting. Before the
commencement of Ramadan, all patients must receive up-to-date education on sick day
rules, instructions on when to terminate their fast or abstain from fasting, carry
steroid warning information and have a valid intramuscular hydrocortisone pack, and
know how to administer this. Switching patients with AI desiring to fast from multiple
daily hydrocortisone replacements to prednisolone 5 mg once daily at dawn (during
Suhoor) was recommended and discussed. They also agreed that patients on fludrocortisone
for AI should be advised to take their total dose at dawn. At the same time, another
group from Tunisia underscored the risks of fasting in patients with adrenal insufficiency,
defined the subjects at risk of complications, and proposed the measures that can
be undertaken for safe fasting.[44] They questioned if the optimal glucocorticoid replacement therapy for safe fasting
had yet been determined. They also highlighted the risk stratification and the importance
of the pre-Ramadan visit for adrenal insufficiency. Failing this, the management of
the adrenal crisis during Ramadan is similar to the standards of care.[44]
Cardiovascular Emergencies
Patients with acute coronary syndrome (ACS) may face health issues during Ramadan
due to lifestyle changes. Five studies explored the relationship between RF and ACS,
and three examined the relationship to heart failure.[45]
[46]
[47]
[48]
[49]
[50]
[51]
[52]
[Table 4] summarizes the ACS studies.[45]
[46]
[47]
[48]
[49] All cardiology studies' salient features and conclusions are reviewed below.
Table 4
Summary of the studies on the acute coronary events during RF
|
Author (ref)
|
Condition, settings
|
Results and conclusions
|
|
Betesh-Abay et al, 2022[45]
|
877 Muslims out of 5,848 had AMI admissions (2002–2017)
|
No difference in AMI incidence in Ramadan vs. before Ramadan was found (p = 0.893). However, post-Ramadan AMI incidence increased (AdjIRR = 3.068, p = 0.018) than before Ramadan. The highest mortality risk was also post-Ramadan
|
|
Sriha Belguith et al, 2016[46]
|
Non-traumatic chest pain at ED (765); Tunisia
|
The ACS (172) was 17% per month before, 22% during, and 28% after RF (p = 0.007). RF was not associated with an increased risk of ACS
|
|
Temizhan et al, 1999[47]
|
Emergency ACS admissions Ankara, Turkiye (1991–1997)
|
RF does not increase acute coronary heart disease events
|
|
Raffee et al, 2020[48]
|
ACS (N = 226); Jordan (2016–2017)
|
There is no significant association between RF in cardiac patients and the occurrence
of ACS
|
|
Al Suwaidi et al, 2006[49]
|
ACS: fasting 162/total 1,019 Qatar (2002–2003)
|
RF does not increase acute coronary heart disease events
|
Abbreviation: ACS, acute coronary syndrome; AdjIRR, Adjusted incidence rate ratio;
AMI, acute myocardial infarction; ED, emergency department; RF, Ramadan fasting.
Author (ref) Condition, Settings Results and conclusions.
The association between acute myocardial infarction (AMI) outcome and RF by comparing
the month preceding Ramadan, Ramadan, and 1 month after Ramadan.[45] Incidents of AMI between Ramadan and 1 month before were the same, while 1-month
post-Ramadan showed an increase in AMI incidence and mortality. Similar findings were
observed by others who studied the 3 months per year before, during, and after RF,
between the years 2012 and 2014.[46] ACS prevalence here was 17% a month before, 22% during, and 28% 1 month after Ramadan,
the prevalence of ACS in patients presenting with chest pain during the RF showed
no increased risk of ACS during Ramadan, but the risk doubled after Ramadan. However,
in a retrospective study of patients hospitalized at ED (1991–1997), ACS events were
significantly lower in Ramadan than before or after Ramadan.[47] Also, another study studied the relation between RF and the occurrence of ACS in
226 patients with main diagnoses of ACS.[48] The authors found no significant association between RF and ACS occurrence. However,
another group investigated the impact of food and sleep lifestyle changes during Ramadan
on the time of presentation of fasting hospitalized patients (162 fasting out of a
total of 1,019). Changes in the timing of food intake and circadian rhythm during
RF might affect the timing of ACS presentation.[49]
Three studies investigated heart failure occurrence during RF with nonconcordant results.
A retrospective review of clinical data was conducted on all Qatari patients hospitalized
for 10 years (January 1991 through December 2001) with heart failure.[50] Patients were divided according to the time of presentation in relation to the month
of Ramadan, 1 month before, during, and 1 month after Ramadan. The number of hospitalizations
for congestive heart failure (CHF) in various periods was analyzed. Of the 20,856
patients treated during the 10 years, 8,446 were Qataris, with 5,095 males and 3,351
females. No significant difference was found in the number of hospitalizations for
CHF while fasting in Ramadan compared with the nonfasting months. Also, data were
derived from Gulf CARE (Gulf aCute heArt failuRe rEgistry), a prospective multicenter
study of consecutive patients hospitalized with acute heart failure (AHF) (2012).
The study included 4,157 patients, of which 306 (7.4%) were hospitalized with AHF
in the fasting month of Ramadan, while 3,851 patients (92.6%) were hospitalized on
other days.[51] The study demonstrated improved volume status in fasting patients. There were also
favorable effects on atrial arrhythmia and total cholesterol and no effects on immediate
or long-term outcomes. On the contrary, in a smaller study of 249 heart failure patients
with reduced ejection fraction (HFrEF) who observed RF, 92% remained hemodynamically
stable, and 8% developed instability.[52] Significantly unstable patients are less adherent to diet and medication and less
likely to cause ischemic cardiomyopathy to be the underlying cause. In most patients
with chronic HFrEF, who are adherent to their medication, RF is safe. However, nonadherence
to diet and medication during Ramadan is associated with increased decompensated heart
failure.
Acute Renal Problems
In nephrology and urology, three groups of acute medical conditions were studied during
Ramadan. [53] These included renal stone disease, colic, and acute kidney injury (AKI) ([Table 5]). These will be discussed briefly below.
Table 5
Summary of studies on the acute events during Ramadan fasting in nephrology and urology
|
Author (ref)
|
Condition, settings
|
Results and conclusions
|
|
Abdolreza et al, 2011[53]
|
Prospective study. 610 patients with RC
|
A significant increase in the incidence of RC during RF. However. other factors may
have an important role
|
|
al-Hadramy, 1997[54]
|
Retrospective study of all males with acute RC attending ED (KSA, 1992–1994)
|
No significant increase in RC in relationship to RF
|
|
Cevik et al, 2016[58]
|
Prospective study, 176 patients with RC before and during Ramadan (Turkey, 2014)
|
RF does not change the number of RC visits
|
|
Al Mahayni et al, 2018[57]
|
Retrospective study, 237 patients with RC over 10 years (KSA)
|
RF does not increase the risk for developing urinary stones compared with nonfasting
months. However, RF during the summer may increase the risk of developing ureter stones
|
|
Al Wakeel, 2014[59]
|
39 CKD and 32 HD patients pre-, during, and post-RF (KSA)
|
CKD and HD patients tolerated 4-hour fasting for 1 month, although there were considerable
changes in some blood chemistry variables. No serious adverse events
|
|
AlAbdan et al, 2022[60]
|
Assessed RF-AKI risk link in 1,199 patients
|
Most patients with comorbid conditions are not harmed by RF. Risk of developing AKI
were significantly lower (adjusted odds ratio 0.65)
|
|
Wan Md Adnan et al, 2014[61]
|
HD in tropical climates – Malaysia
|
RF is associated with reduced weight and improved serum albumin and phosphate level
in HD patients
|
|
Adanan et al, 2021[62]
|
HD patients cohort – Malaysia
|
HD patients' experiences and perceptions regarding RF warrants the need for effective
communication with patients
|
Abbreviations: AKI, acute kidney injury; CKD, chronic kidney disease; HD, hemodialysis;
KSA, Kingdom of Saudi Arabia; RC, renal colic; RF, Ramadan fasting.
There are concerns about whether the occurrence of renal colic (RC) increases during
Ramadan. A prospective observational study investigated patients with symptoms of
RC who were referred to the emergency wards in two major hospitals in Iran.[53] The study period was divided into 2 weeks before the commencement of Ramadan (stage
1), during the first 2 weeks (stage 2), the last 2 weeks (stage 3), and 2 weeks after
Ramadan (stage 4). During the study period, 610 subjects were admitted with RC; there
were 441 males (72.3%) and 169 females (27.7%). The number of patients with RC was
highest during the first 2 weeks of Ramadan compared with the other periods (stage
1: 157, stage 2: 195, stage 3: 139, stage 4: 119, p < 0.05). This study shows that the number of admissions due to RC was high during
the first 2 weeks of Ramadan. However, admissions decreased during the last 2 weeks
of Ramadan, and this trend continued after Ramadan. Also, a retrospective study examined
ER records in Jeddah, an area with a high prevalence of urolithiasis, for three consecutive
years to determine the effect of climatic changes on the occurrence of urinary stone
colic.[54] Males diagnosed with urinary colic during this period were recorded monthly. Data
were recorded before, during, and after Ramadan. The results showed a steady increase
in urinary stone colic in the hot season, with a maximum rate in June, July, and August.
The mean number of males with stone colic in these months was 45.33, 44.19, and 45.16,
respectively. The lowest number was in March (28.06), with a rate of 4.11 per 1,000
patients. A strong correlation was found between urinary stone colic and temperature
and atmospheric pressure with a p-value of < 0.0001. No significant correlation was observed with relative humidity.
Similarly, RF and the pilgrimage festival remained the same. These results suggest
a clear seasonal corresponding of stone to the hot summer months in this area. No
significant increase in urinary stone colic was observed concerning the fasting month
of Ramadan or the pilgrimage festival. Although RC is associated with high ambient
temperature and physiological changes during fast, the literature on Ramadan and RC
incidence is scarce. Furthermore, visits during RF to a large tertiary center from
2004 to 2015 with a primary diagnosis of RC were analyzed. The two ethnic groups residing
in the locality (Palestinian Muslims and Jews) were compared.[55] They identified 10,435 unique patients with 18,163 ED visits with a primary diagnosis
of RC. However, the Palestinians, who represent 18.5% of the population in the region,
contributed approximately 25% of the ED visits with RC. After adjusting for seasons,
there was a positive and significant association between temperature and ED visits
within all subgroups. Positive association with Ramadan was observed during the first
2 weeks of fasting among Muslims (relative risk [RR] 1.27) but not among Jews (RR
1.061). However, commenting on these data, it was argued that ethnicity could be a
confounding factor since the control nonfasting group was from a completely different
ethnic group. The genetic factors and diet may make the comparison between the two
groups misleading.[56]
Regarding RC, the RC frequency secondary to urinary stones in Ramadan was compared
with other months and seasons in a retrospective cross-sectional study.[57] They used the medical records of 237 patients admitted through the ER with a diagnosis
of RC secondary to urinary stones over 10 years at King Abdulaziz Medical City, Riyadh,
Saudi Arabia. Patients fasting during Ramadan are two times more likely to present
with calculus of the ureter than calculus in another location in the urinary tract,
mainly when the holy month of Ramadan falls in the summer season. There was no significant
difference in the frequency of urinary stones between Ramadan and non-Ramadan months.
Therefore, they concluded that RF does not increase the risk of developing urinary
stones compared with nonfasting months. However, another study evaluated the effects
of RF on the number of RC-related ED visits and laboratory results of patients with
RC in a prospective observational study.[58] The study period was divided into two parts: before and during Ramadan. All laboratory
results of patients and daily air temperature values were recorded. A total of 176
patients (n: 89 before Ramadan, n: 87 in Ramadan) with RC were enrolled in the study. During Ramadan, 73.1% of patients
were admitted in the first half of the month, and 26.9% were admitted in the second
half. Only urine density and white blood cell values in Ramadan and non-Ramadan periods
differed significantly (p = 0.004 and p = 0.001). Hemoglobin, available crystal, and triple phosphate crystal values in the
first and the second half of Ramadan were significantly different (p = 0.04, p = 0.03, and p = 0.03). This study highlighted that fasting during Ramadan does not change the number
of RC visits. In addition, although fasting causes some changes in urinary metabolites,
there is not enough evidence that these changes increase urinary calculus formation.
Lastly, the effects of RF were assessed among CKD and hemodialysis (HD) patients in
a prospective study seen in 2010 at two university hospitals (Saudi Arabia).[59] Volunteers among CKD and HD patients were evaluated for kidney function and complications
before, during, and after RF (14 hours). A modified schedule for medication and dialysis
regimen was provided to the participants. Thirty-nine CKD patients (41.0% in stage
3 and 43.6% in stage 4) were included. There were no differences in the laboratory
and clinical variables before, during, and after the fasting month. Thirty-two HD
patients with a mean duration of dialysis of 4.4 years were also included in the study.
During the fasting period, there was a significant increase in erythrocyte count,
serum creatinine, blood urea, serum phosphorus, serum albumin, and serum uric acid
levels. Hyperkalemia developed in 25.0 and 15.6% of the HD patients during and after
the fasting period, and hyponatremia in 15.6 and 28.0%, respectively. Forty-six percent
of the patients developed hypertension and 36.7% fluid overload. No adverse events
requiring hospital admission were observed. Thus, CKD and HD patients tolerated 4-hour
fasting for 1 month, although there were considerable changes in some blood chemistry
variables. No serious adverse events occurred.
Also, the relationship between fasting and the risk of AKI and identified patients
at high risk was assessed in a single-center, retrospective, propensity-score-matched
cohort study using data collected from adult patients admitted to the ED during Ramadan
the following month over two consecutive years (2016 and 2017).[60] A total of 1,199 patients were included; each cohort had 499 patients after matching.
In the fasting cohort, the incidence of AKI and the risk of developing AKI were significantly
lower (adjusted odds ratio [AOR] 0.65). The most indicative risk factors for AKI were
hypertension (AOR 2.17), history of AKI (AOR 5.05), and liver cirrhosis (AOR 3.01).
Patients with these factors or most other comorbidities in the fasting cohort had
a lower risk of AKI than their nonfasting counterparts. Furthermore, the effect of
RF on HD patients in tropical climates was examined in a prospective cross-sectional
study that recruited Muslim patients on regular HD from three HD centers in Kuala
Lumpur.[61] Patients who fasted for any number of days were included (n = 35, 54% female, age 54 years). Eighty-nine percent of patients fasted for more
than 15 days, and 49% had diabetes. Both pre- and postdialysis weights were significantly
decreased during RF compared with the month prior (p ≤0.001). There was a significant decrease in ultrafiltration (p = 0.002). There were no significant differences in dry weight, interdialytic weight
gain, mean urea reduction ratio, or blood pressure measurements comparing pre- and
end-of-RF. There was a significant increase in serum albumin level (p = 0.006) and a decrease in serum phosphate level (p = 0.02) at the end of Ramadan. Finally, in an experimental phenomenology qualitative
study studied the experiences and perceptions of Muslim HD patients observing RF from
three HD centers (Malaysia).[62] Four major themes emerged from the data, namely: (1) “fasting experiences,” (2)
“perceived side effects of fasting,” (3) “health-seeking behavior,” and (4) “education
and awareness needs.” Patients expressed the significance of RF and the perceived
impact of fasting on their health. Additionally, there is a lack of health-seeking
behavior observed among patients, thus, raising the need for awareness and education
related to RF.
Acute Gastrointestinal Problems
The main medical conditions that had acute complications were related to peptic ulcer
disease (PUD), as shown in [Table 6].[63]
[64]
[65]
[66]
[67] These will be discussed briefly below. A prospective observation of a cohort of
516 patients with PUD before, during, and after RF was performed. They found no differences
in the worsening of peptic acid disease during Ramadan compared with the durations
before and after Ramadan.[63] Also, the relationship between RF and duodenal ulcer perforation was evaluated,
and the risk factors for peptic disease in RF were assessed.[64] A retrospective analysis was conducted for all patients who underwent surgery for
duodenal ulcer perforation in the emergency service between 1998 and 2003. Comparisons
were made between patients who were operated on in Ramadan within 5 years (5 months
during the study period) (group 1) and during the remaining periods (55 months during
the study period) (group 2). Two hundred and sixty patients were included (50 in group
1 and 210 in group 2) in the study. The number of surgeries per month was statistically
high in group 1 than in group 2 (10 patients per month vs. 3.8 patients per month,
p < 0.018). Predisposing factors play a significant role and may be the reason for
the difference. This study suggests that duodenal ulcer perforation is relatively
high in Ramadan among the fasting and has predisposing factors (especially a history
of dyspepsia). Therefore, they believe that people with predisposing factors and dyspeptic
symptoms must be well-informed and need special care. Also, the study of the effect
of RF on PUD and its complications in patients presenting to the ED at Al-Ain Hospital,
UAE, was conducted.[65] The authors retrospectively reviewed patient records over the 10 years, 1992 to
2002. Of the patients treated for PUD, 215 were seen during Ramadan and 255 in the
month after Ramadan. The frequency of PUD was higher after Ramadan than during Ramadan,
but this was not statistically significant. PUD occurred more frequently in the age
group of 30 to 49 years. In addition, the effects of RF on peptic ulcers and acute
upper gastrointestinal bleeding were investigated.[66] They studied all patients admitted to the hospital with acute upper gastrointestinal
bleeding from the 10th day of Ramadan till 1 month later, from 2002 to 2004. Patients
were divided into two groups: the fasting group fasting at least 10 days before admission,
and the nonfasting group. The study included 236 patients (108 fasting and 128 nonfasting
groups). The fasting group showed more frequent duodenal ulcers (38%) compared with
the nonfasting group (19.5%) (p = 0.002). The frequency of esophageal varices was significantly higher in the nonfasting
group. There was no correlation between fasting and other causes of gastrointestinal
bleeding. In the fasting group, 38%, and in the nonfasting group, 18.9% had previous
dyspeptic symptoms (p = 0.001). The two groups were similar regarding prognostic factors. Also, the epidemiological
characteristics and clinical results of patients who presented with acute upper gastrointestinal
hemorrhage (AUGIH) during the month of Ramadan (October 2007) were compared with those
who presented with AUGIH during another non-Ramadan month (December 2007) in a study
that evaluated multiple parameters, including age, sex, symptoms, gastrointestinal
disease history, risk factors, coexisting diseases, results of rectal, nasogastric,
and endoscopic examinations, treatment modalities, and clinical outcomes.[67] Significantly more patients were diagnosed with AUGIH during Ramadan than in a non-Ramadan
month (43 vs. 28, respectively). Significantly more patients diagnosed during Ramadan
had a previous hemorrhage history than the non-Ramadan month (72.1% vs. 42.9%, respectively).
The most common event in both groups was a peptic ulcer; overall endoscopy findings
differed. No other significant differences were found.
Table 6
Summary of the risk of peptic acid disease and complications of gastrointestinal conditions
during RF
|
Authors (year)
|
Study variables
|
Settings
|
Findings/Conclusion
|
|
Al-Kaabi et al, 2004[63]
|
516 patients with PUD
|
ED patients, Al Ain, UAE
|
No change in PUD during Ramadan
|
|
Kucuk et al, 2005[64]
|
Patients operated on in Ramadan (N = 50); patients operated on in remaining periods (N = 210)
|
Retrospective hospital study (1998–2003)
|
Surgeries per month were higher in the RF than non-RF group (10 vs. 3.8 per month,
p < 0.018)
|
|
Bener et al, 2006[65]
|
PUD (215 fasting, 265 not fasting)
|
ED, Al Ain, UAE, 1992–2002
|
PUD perforation tended to occur more frequently insignificantly after RF
|
|
Emami and Rahimi, 2006[66]
|
Peptic ulcer and acute upper gastrointestinal bleeding
|
Hospital admissions, 2002–2004, Isfahan, Iran
|
RF can increase acute upper GI bleeding due to DU, but it does not worsen the prognosis
|
|
Ozkan et al, 2009[67]
|
AUGIH (43 during RF vs. 28 non-RF)
|
ED, Erciyes University Hospital, Kayseri, Turkey
|
Patients presenting with AUGIH during Ramadan is significantly higher than that in
an ordinary month
|
Abbreviations: AUGIH, acute upper gastrointestinal hemorrhage; DU, duodenal ulcer;
ED, emergency department; GI, gastrointestinal; PUD, peptic ulcer disease; RF, Ramadan
fasting; UAE, United Arab Emirates.
Whether acute pancreatitis (AP) is more common in individuals who celebrate it during
RF was addressed.[68] The occurrence of AP in a fasting population and a nonfasting population during
Ramadan versus the rest of the year was undertaken. Over the 10-year study period,
1,167 patients were admitted to the ED with AP. Of these, 91.6% were nonfasting, and
98 (8.4%) were fasting. Of these, 17.3% of fasting and 8.8% of nonfasting patients
were admitted with AP during Ramadan (RR: 1.12; OR: 2.15; p = 0.01). During Ramadan, the rate of AP out of referrals was 0.1% in fasting patients
versus 0.004% in nonfasting individuals (OR: 2.54). During the other months of the
year, the rate of AP out of referrals was 0.009% in fasting patients versus 0.008%
in nonfasting individuals (p < 0.001). Given a high rate of AP in the fasting population during Ramadan in the
studied cohort, they urged physicians to be aware of the link and suspect it for fasting
patients presenting with epigastric pain during the Ramadan fast.
Acute Neurological Problems
The most common diseases in Ramadan and Shawal were ischemic stroke (36.7 and 40%),
seizure (27.1 and 23.3%), and headache (12 and 14.7%), respectively. They did not
find significant differences in sex, age, marital state, incidence and admission time,
and risk factors for neurologic diseases between Ramadan and Shawal (p > 0.05). In this study, the admission rate for most neurological diseases was not
significantly different in Ramadan and Shawal. Providing appropriate medical advice
could considerably prevent neurological disorders during Ramadan.[69] However, in more focused studies, other workers associated three classes of acute
neurological problems of varying severity with RF ([Table 7]). Patients may present to emergency or urgent care services. They include headache
disorders, uncontrolled epilepsy, and stroke.[70]
[71]
[72]
[73]
[74]
[75]
[76]
[77] The various studies are discussed briefly below.
Table 7
Patterns and types of acute neurological conditions during Ramadan fasting
|
Authors (year)
|
Study variables
|
Settings
|
Findings/Conclusion
|
|
Drescher et al, 2012[70]
|
189 on etoricoxib vs. 92 on placebo for “first of Ramadan” headache
|
DBPC: 90 mgs etoricoxib
|
Etoricoxib reduced the incidence of headache
|
|
Bener et al, 2006[71]
|
335 patients were hospitalized for stroke; 29 cases in the month before, 30 during
Ramadan, 29 in the month after Ramadan
|
Retrospective review of 13-year stroke database; Doha, Qatar
|
No significant difference in hospitalizations for stroke during Ramadan compared with
the non-fasting months. Risk factors were not different
|
|
Assy et al, 2019[72]
|
220 patients diagnosed with cerebrovascular stroke during Ramadan, 1 month before
and 1 month after
|
Medical ICU (Zagazig, Egypt)
|
No increase in stroke in patients with diabetes during RF with nonsignificant trend
for more ischemic than hemorrhagic stroke
|
|
Saadatnia et al, 2009[73]
|
Impact of RF on cerebral venous (162) and sinus thrombosis (33)
|
Neurocenters, Isfahan, (2001–2006)
|
Significant increase in cerebral venous sinus thrombosis events in RF
|
|
El-Mitwalli et al, 2009[74]
|
517 Muslim patients admitted either in Ramadan or the month before in two consecutive
years
|
Systematic reviews of all major databases
|
RF has no effects on stroke frequency, type, and severity
|
|
Salama and Belal, 2014[75]
|
1,062 cerebral stroke patients admitted during Ramadan and the month before
|
University hospitals (Mansoura, Egypt)
|
No significant differences apart from high mortality rate, hematocrit, and hyperlipidemia
among fasting persons
|
|
Magdy et al, 2022[76]
|
Observational study of the effect of fasting on seizure type and frequency. 320 patients
in 3 months including Ramadan
|
Cairo University Hospitals, Cairo, Egypt
|
No difference in generalized tonic-clonic seizures in the 3 months. RF may improve
effect on active focal, myoclonic, and absence seizures
|
Abbreviations: DBPC, double-blind placebo-controlled; ICU, intensive care unit; RF,
Ramadan fasting.
In a double-blind, randomized prospective crossover trial of etoricoxib 90 mg versus
placebo by Drescher et al, taken just before the onset of fasting during the first
2 weeks of Ramadan 2010 in healthy adults, 189 completed the postfast questionnaire.[70] Etoricoxib reduced the incidence of “first of Ramadan headache” to 46% in the placebo
group versus 21% in the etoricoxib group (OR 3.19; p < 0.0001). The difference was evident in the first week only.
Bener et al in a 13-year observational study, did not find any significantly increased
risk factors in hospitalized patients with stroke between Ramadan and other nonfasting
months.[71] Similarly, Assy et al came to the same conclusion.[72] However, Saadatnia et al found a significant increase in cerebral venous and sinus
thrombosis during Ramadan (5.5 patients per month in Ramadan vs. 1.95 in nonfasting
months).[73] El-Mitwalli et al found no correlation between fasting duration and stroke frequency
and type. RF does not affect stroke frequency, type, and severity.[74] Similarly, another prospective study studied 1,062 cerebral stroke patients admitted
to university hospitals (Mansoura, Egypt) 1 month before (BR), during (DR), and after
(AR) Ramadan over three consecutive years.[75] However, during Ramadan, most ischemic stroke onset was around noon (9 a.m. to 4
p.m.).
The effect of RF on the seizure type in a prospective observational study on Muslim
patients with active epilepsy intending to fast during Ramadan, 1 month before, and
1 month after, in 2019, found that the frequency of generalized tonic-clonic seizures
did not significantly differ between the 3 months.[76] RF may have an improving effect and a postfasting effect on active focal, myoclonic,
and absence seizures.
Acute Hematological Conditions
The three studies that considered the acute disturbances of hematological conditions
were related to anticoagulation therapy during RF.[77]
[78]
[79] RF effect on the international normalized ratio (INR) variations was assessed in
30 patients (mean age 65 years; equal sex) treated with acenocoumarol in a prospective
monocentric study.[77] Mean INR was significantly higher during RF than baseline (3.51 vs. 2.52; p < 0.0001). There were also more overdoses during RF than at baseline (9 vs. 0; p = 0.014). Also, the changes in the INR and the percentage of time within the therapeutic
range (%TTR) were evaluated before, during, and after Ramadan in stable warfarin-used
fasting patients.[78] Among 32 participating patients, the mean INR increased by 0.23 (p = 0.006) during RF from the pre-Ramadan month and decreased by 0.28 (p < 0.001) after Ramadan. There was no significant difference (p = 1.000) in mean INR between the non-Ramadan months. %TTR declined from 80.99% before
Ramadan to 69.56% during Ramadan (p = 0.453). The first out-of-range INR was seen around 12.1 days after the start of
RF and returned to the range at approximately 10.8 days after. The time above range
increased from 10.8% pre-Ramadan to 29.9% during Ramadan (p = 0.027), while the time below range increased from 0.57% during Ramadan to 15.49%
post-Ramadan (p = 0.006). No bleeding or thrombotic events were recorded. Furthermore, the INR values
and time within the TTR were examined during pre-RF, RF, and post-RF periods in 101
fasting warfarin-treated adults (mean age 55.8 years; 52.4% females). Finally, the
target INR range for 62.4% was 2 to 3, while 37.6% had a target INR range of 2.5 to
3.5. An upward trend in the proportion of patients with therapeutic INR was noticed
during Ramadan (59.4%) as compared with the pre- (56.4%) and post-Ramadan periods
(53.5%), respectively.[79] Additionally, the proportions of patients with supratherapeutic and subtherapeutic
INR were the highest and lowest, 23 and 24%, respectively, post-Ramadan compared with
other periods. Based on target INR categorization, achieving therapeutic INR during
RF was more feasible with the low INR (2–3) compared with the high INR (2.5–3.5) target
patients, 63.5% versus 52.6%, respectively. TTR estimation revealed that 62.4 and
37.6% of the patients had good and poor anticoagulation status throughout the study
period. These studies suggest that close monitoring of INR values may be needed during
RF, particularly in patients with a high hemorrhagic risk, even in medically stable
patients.
Bioethical Considerations
Several bioethical challenges need to be considered when considering the interplay
between RF and the needs of a patient attending an ED while fasting. Clinical literature
has increased the awareness of the importance of proper communication between doctor
and patient to determine the diagnostic-therapeutic plan, especially in individuals
with different linguistic and intercultural differences. Two groups from different
parts of the world reflected on various relevant issues. Leo et al reported their
experience with multiculturalism in Italy.[80] Health care professionals must address anthropological, moral, religious, and political
issues implied in populations and cultures different from their own. RF is an excellent
example of how a deep understanding of intercultural values is vital to meet the health
care needs of individuals with different cultural norms. In addition, Erbay et al
used a sample case encountered by ambulance staff in the basic principles of medical
ethics.[81] The encounter follows a motor vehicle accident during Ramadan, and the patient is
fasting. The patient states that he is fasting and will be broken, and his religious
practice will be disrupted if the serum is administered. The ambulance doctor and
the patient argue opposite viewpoints. The ambulance physician has little time to
decide. The authors use the scenario to deliberate on treating the patient. Which
type of behavior will create the least erosion of his values? The physician's experience
and the case illustrate that multiethnicity allows health care professionals to adopt
new cultural and social skills and tools to cope with diverse patients.
