J Neurol Surg B Skull Base 2023; 84(S 01): S1-S344
DOI: 10.1055/s-0043-1762268
Presentation Abstracts
Poster Abstracts

Tumors Involving the Infratemporal Fossa: A Systematic Review of Clinical Characteristics and Treatment Outcomes

Othman Bin-Alamer
1   Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States
,
Lokeshwar S. Bhenderu
2   Texas A&M University College of Medicine, Houston, Texas, United States
,
Kishore Balasubramanian
2   Texas A&M University College of Medicine, Houston, Texas, United States
,
Prashant Upadhyay
3   Government Medical College Jalaun, Uttar Pradesh, India
,
Paolo Palmisciano
4   Department of Neurosurgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States
,
Tarek Y. El Ahmadieh
5   Department of Neurosurgery, Loma Linda University School of Medicine, Loma Linda, California, United States
,
Kenny Yu
6   Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, New York, United States
,
Aaron A. Cohen-Gadol
7   Department of Neurological Surgery, Indiana University School of Medicine, Indianapolis, Indiana, United States
,
Ali S. Haider
8   Department of Neurosurgery, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States
› Author Affiliations
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    Purpose: To review the literature on tumors invading the infratemporal fossa (ITF) and describe the patient characteristics, treatment strategies, and clinical outcomes.

    Methods: Relevant articles were retrieved from PubMed, Scopus, and Cochrane. A systematic review and meta-analysis was conducted on the clinical presentation, treatment protocols, and clinical outcomes.

    Results: A total of 27 articles containing 106 patients with ITF tumors (median tumor size: 24.3 cm3 [interquartile range, 15.2–42 cm3]) were included (median age: 46 years [interquartile range, 32–55 years]; 59.4% were males]). Of the confirmed tumor pathology data, schwannomas (N = 24; 26.1%) and meningiomas were the most common tumors. Facial hypoesthesia (N = 22; 18.5%), auricular/preauricular pain (N = 20; 16.8%), and headaches (N = 11; 9.2%) were the most common presenting symptoms. Of patients who had surgical resection (N = 97; 95.1%), 70 (73.7%) had transcranial surgery (TCS) and 25 (26.3%) had endoscopic endonasal surgery (EES). Among available details on the extent of resection (N = 84), gross-total resection (GTR) was achieved in 62 (73.8%), and 5 (6.0%) had biopsy only. Thirty-five (33.0%) patients had postoperative complications. Among cases with available data on reconstruction techniques (N = 8), four (50%) had adipofascial anterolateral thigh flap, 3 (37.5%) had latissimus dorsi free flap, and one (12.5%) had antero-lateral thigh flap. Fourteen (13.2%) patients had adjuvant chemotherapy, and 16 (15.1%) had adjuvant radiotherapy. During a median follow-up time of 28 months (IQR, 12.25–45.75 months), 15 (14.2%) patients had a recurrence, and 18 (17.0%) patients died. The median overall survival (OS) time was 36 months (95% confidence interval: 29–41 months), and the 5-year progression-free survival (PFS) rate was 61%. The multivariable analyses of the OS, PFS, and complication did not detect any significant predictive factors.

    Conclusion: Various tumor types with different biological behaviors invade the ITF. The present study describes the patient demographics, clinical presentation, management, and outcomes. Depending on the tumor type and patient condition, patient-tailored management is recommended to optimize treatment outcomes.

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    No conflict of interest has been declared by the author(s).

    Publication History

    Article published online:
    01 February 2023

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