Serum Fibroblast Growth Factor 1 is Associated with the Decreased Risk of Obesity in Human

Abstract

Background

As a transducer of PPARγ signaling, recent evidence supports that fibroblast growth factor 1 (FGF1) mediates adipose tissue remodeling and insulin sensitivity.

Aims

This study is to assess the role of serum FGF1 in obesity.

Methods

A hospital-based case-control study of 154 subjects was conducted. Serum level of FGF1 was measured by enzyme-linked immunosorbent assay.

Results

The serum level of FGF1 in the lean (119.0 [103.1–146.1] pg/ml) was higher than it in the subjects with overweight/obesity (111.9 [80.3–127.4] pg/ml, P=0.009). Binary logistic regression models found a reverse association between serum FGF1 level and the risk of overweight/obesity (adjusted odds ratio=0.990, 95% confidence interval [0.981–0.998], P=0.019). Furthermore, serum FGF1 reversely correlated with body mass index (r=−0.176, P=0.029), systolic blood pressure (r=−0.224, P=0.005), diastolic blood pressure (r=−0.185, P=0.022) and triglycerides (r=−0.162, P=0.044). Multiple stepwise linear regression analysis found serum level of FGF1 was dependent on anti-diabetic drugs, hemoglobin A1C, body mass index and sex.

Conclusions

Serum level of FGF1 is associated with the decreased risk of obesity in human.

Key words

case-control - fibroblast growth factor 1 (FGF1) - peroxisome proliferator-activated receptor γ (PPARγ) - obesity - diabetes

^* J. Zhu and Y. Wang contributed equally to the work.

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