Morbus Alzheimer – Ansätze für die Prävention und Therapie

Zusammenfassung

Der dramatische Anstieg der Alzheimer-Erkrankung im Alter, als Zeichen zunehmender Neurodegeneration muss als Resultat vermehrter oxidativer und inflammatorischer Prozesse im Gehirn betrachtet werden, wobei Chemikalien (z. B. Aluminium, Biozide, Endocrine Disruptors), AGEs, Fette und Mangel an protektiven Nährstoffen wesentliche Auslöser sind. Mangel an körperlicher Aktivität und geringe kognitive Reserve, durch reduzierte geistige und soziale Aktivität, verstärken die degenerativen Effekte. Sinnvolle Ansätze müssen sich v.a. auf die Prävention konzentrieren und möglichst viele der krankheitsfördernden Effekte früh im Leben reduzieren oder ausschalten. Die beste Prävention und Therapie stellt daher ein biologischer Lebensstil schon in jungen Jahren dar. Dazu gehören vollwertige und gesunde Lebensmittel ohne Chemie sowie eine gute Versorgung mit allen wichtigen Nährstoffen. Dies würde die ursächlichen Prozesse wie die AGE/RAGE/NF-kB-Kaskade, oxidativen Stress und Neuroinflammation deutlich reduzieren. Regelmäßige körperliche Aktivität, ausreichende Ruhe und Erholungszeiten (für die Zellregeneration), wie auch geistige und soziale Aktivität bis ins Alter würden die Neurogenese deutlich erhöhen. Dieser Ansatz ist nicht nur wesentlich effektiver als jedes eventuelle Medikamente, er hat auch keine Nebenwirkungen.

Abstract

The dramatic rise of the Alzheimer’s disease in old age, as an indication for an increasing neurodegeneration, has to be seen as the result of an increased number of oxidative and inflammatory processes in the brain, where chemicals (e. g. aluminum, biocides, endocrine disruptors), AGEs, fats, and a lack of protective nutrients are the main triggers. A lack of physical activity and a low cognitive reserve, due to a reduced mental and social activity, intensify the degenerative effects. Useful approaches must primarily concentrate on prevention, and reduce or remove as many disease-promoting effects as possible early in life. The best prevention and therapy is a biological lifestyle already at an early age. This includes wholesome and healthy food without any chemicals as well as a good supply of all the important nutrients. This would significantly reduce causal processes like the AGE/RAGE/NF-kB cascade, oxidative stress, and neuroinflammation. Regular physical activity, sufficient rest and recovery times (for cell regeneration) as well as mental and social activity up to old age would significantly increase neurogenesis. This approach is not only much more effective than any drug, it also has no side effects.

Schlüsselwörter

Alzheimer-Erkrankung - AGEs - Agrochemikalien - Aluminium - Ernährung - oxidativer Stress

Keywords

Alzheimer’s disease - AGEs - agrochemicals - aluminum - nutrition - oxidative stress

• Literatur

• 1 Baldi I. Neurodegenerative Diseases and Exposure to Pesticides in the Elderly. Am J Epidemiol 2003; 157: 409-414
• 2 Chen CW. Increased risk of dementia in people with previous exposure to general anesthesia: a nationwide population-based case-control study. Alzheimers Dement 2014; 10 (02) 196-204
• 3 Cornutiu G. The incidence and prevalence of Alzheimer’s disease. Neurodegener Dis 2011; 8 (01) -2 9-14
• 4 Friedrichsen HP. Alzheimer – eine vermeidbare Umwelterkrankung?. Zs f Orthomol Med 2016; 1: 3-9
• 5 Kalmijn S, Feskens EJM, Launer LJ. et al. Polyunsaturated fatty acids, antioxidants, and cognitive function in very old men. Am J Epidemiol 1997; 145: 33-41
• 6 Klatzo I, Wisniewski H, Streicher E. Experimental production of neurofibrillary degeneration I. Light microscopic observation. JNeuropathol Exp Neurol 1965; 24: 187-199
• 7 Perrone L. Observational and ecological studies of dietary advanced glycation end products in national diets and Alzheimer’s disease incidence and prevalence. J Alzheimers Dis 2015; 45 (03) 965-979
• 8 Richardson J. Elevated Serum Pesticide Levels and Risk for Alzheimer Disease. JAMA Neurol 2014; 71 (03) 284-290
• 9 Rondeau V. Relation between Aluminum Concentrations in Drinking Water and Alzheimer’s Disease: An 8-year Follow-up Study. Am J Epidemiol 2000; 152: 59-66
• 10 Santos-Lozano A. Physical Activity and Alzheimer Disease. Mayo Clin Proc 2016; 91 (08) 999-1020
• 11 Sasaki N, Fukatsu R, Tsuzuki K. et al. Advanced glycation end products in Alzheimer’s disease and other neurodegenerative diseases. Am J Pathol 1998; 153: 1149-1155
• 12 Sayed S. Aluminium content of some foods and food products in the USA, with aluminium food additives. Food Addit Contam 2005; 22 (03) 234-244
• 13 Srikanth V. Advanced glycation endproducts and their receptor RAGE in Alzheimer’s disease. Neurobiology of Aging 2011; 32 (05) 763-777
• 14 Stangl D, Thuret S. Impact of diet on adult hippocampal neurogenesis. Genes Nutr 2009; 4: 271-282
• 15 Uribarri J. Advanced Glycation End Products in Foods and a Practical Guide to Their Reduction in the Diet. J Am Diet Assoc 2010; 110 (06) 911-916 e12
• 16 Virk SA. Aluminum levels in brain, serum und cerebrospinal fluid are higher in Alzheimer’s Disease cases than in controls. JAlzheimer disease 2015; 43 (03) 629-38
• 17 Yi SW. Agent Orange exposure and disease prevalence in Korean Vietnam veterans: the Korean veterans health study. Environ Res 2014; 133: 56-65