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Planta Med 2017; 83(09): 778-789
DOI: 10.1055/s-0043-104382
Biological and Pharmacological Activity
Original Papers

Clinical Parameters following Multiple Oral Dose Administration of a Standardized Andrographis paniculata Capsule in Healthy Thai Subjects

Tawit Suriyo
1   Laboratory of Pharmacology, Chulabhorn Research Institute, Bangkok, Thailand
2   Center of Excellence on Environmental Health and Toxicology, Office of Higher Education Commission, Ministry of Education, Bangkok, Thailand
,
Nanthanit Pholphana
1   Laboratory of Pharmacology, Chulabhorn Research Institute, Bangkok, Thailand
,
Teerapat Ungtrakul
3   Chulabhorn Hospital, Chulabhorn Royal Academy, Bangkok, Thailand
,
Nuchanart Rangkadilok
1   Laboratory of Pharmacology, Chulabhorn Research Institute, Bangkok, Thailand
2   Center of Excellence on Environmental Health and Toxicology, Office of Higher Education Commission, Ministry of Education, Bangkok, Thailand
4   Chulabhorn Graduate Institute, Chulabhorn Royal Academy, Bangkok, Thailand
,
Duangchit Panomvana
5   Translational Research Unit, Chulabhorn Research Institute, Bangkok, Thailand
,
Apinya Thiantanawat
1   Laboratory of Pharmacology, Chulabhorn Research Institute, Bangkok, Thailand
2   Center of Excellence on Environmental Health and Toxicology, Office of Higher Education Commission, Ministry of Education, Bangkok, Thailand
4   Chulabhorn Graduate Institute, Chulabhorn Royal Academy, Bangkok, Thailand
,
Wanwisa Pongpun
3   Chulabhorn Hospital, Chulabhorn Royal Academy, Bangkok, Thailand
,
Jutamaad Satayavivad
1   Laboratory of Pharmacology, Chulabhorn Research Institute, Bangkok, Thailand
2   Center of Excellence on Environmental Health and Toxicology, Office of Higher Education Commission, Ministry of Education, Bangkok, Thailand
4   Chulabhorn Graduate Institute, Chulabhorn Royal Academy, Bangkok, Thailand
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Abstract

Andrographis paniculata has been widely used in Scandinavian and Asian counties for the treatment of the common cold, fever, and noninfectious diarrhea. The present study was carried out to investigate the physiological effects of short-term multiple dose administration of a standardized A. paniculata capsule used for treatment of the common cold and uncomplicated upper respiratory tract infections, including blood pressure, electrocardiogram, blood chemistry, hematological profiles, urinalysis, and blood coagulation in healthy Thai subjects. Twenty healthy subjects (10 males and 10 females) received 12 capsules per day orally of 4.2 g of a standardized A. paniculata crude powder (4 capsules of 1.4 g of A. paniculata, 3 times per day, 8 h intervals) for 3 consecutive days. The results showed that all of the measured clinical parameters were found to be within normal ranges for a healthy person. However, modulation of some parameters was observed after the third day of treatment, for example, inductions of white blood cells and absolute neutrophil count in the blood, a reduction of plasma alkaline phosphatase, and an induction of urine pH. A rapid and transient reduction in blood pressure was observed at 30 min after capsule administration, resulting in a significant reduction of mean systolic blood pressure. There were no serious adverse events observed in the subjects during the treatment period. In conclusion, this study suggests that multiple oral dosing of A. paniculata at the normal therapeutic dose for the common cold and uncomplicated upper respiratory tract infections modulates various clinical parameters within normal ranges for a healthy person.

Key words

Andrographis paniculata - Acanthaceae - blood pressure - blood chemistry - hematological profiles - urinalysis - electrocardiogram

Supporting Information

Representative electrocardiograms of the subject and representative HPLC chromatograms of four major active diterpenoides of A. paniculata in the capsule and subjectsʼ plasma are available as Supporting Information.



Publication History

Received: 18 November 2016

Accepted after revision: 14 February 2017

Publication Date:
01 March 2017 (online)

© 2017. Thieme. All rights reserved.

Georg Thieme Verlag KG
Stuttgart · New York

 

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