Fortschr Neurol Psychiatr 2017; 85(05): 274-279
DOI: 10.1055/s-0043-103084
Originalarbeit
© Georg Thieme Verlag KG Stuttgart · New York

Risikofaktoren des postoperativen Deliriums in der Herzchirurgie.

Risk Factors for Postoperative Delirium after Cardiac Surgery
Christian Gernhardt
1   Klinik für Psychiatrie und Psychotherapie, Universität Lübeck
,
Sophie Kluge
1   Klinik für Psychiatrie und Psychotherapie, Universität Lübeck
,
Mira Meon
1   Klinik für Psychiatrie und Psychotherapie, Universität Lübeck
,
Claudia Schmidtke
2   Kardiochirurgie, Herzzentrum der Segeberger Kliniken Gruppe, Bad Segeberg
,
Antje Karluß
3   Klinik für Herzchirurgie, Universität Lübeck
,
Beate Sedemund-Adib
4   Klinik für Anästhesiologie, Universität Lübeck
,
Tilman Wetterling
5   Psychiatrie, Vivantes Klinikum Kaulsdorf, Berlin
,
Hans-Hinrich Sievers
6   Klinik für Kardiochirurgie, Universität Lübeck
,
Klaus Junghanns
1   Klinik für Psychiatrie und Psychotherapie, Universität Lübeck
› Author Affiliations
Further Information

Publication History

Publication Date:
23 May 2017 (online)

Zusammenfassung

Hintergrund Das Delir ist eine häufige Komplikation nach Herzoperationen und mit negativen Folgen wie erhöhter Mortalität und Morbidität verbunden. Daher ist die Kenntnis von Risikofaktoren für präventive Maßnahmen erforderlich.

Fragestellung Welches sind prädisponierende Risikofaktoren des Delirs?

Methodik Prospektive Longitudinalstudie an 241 elektiven herzchirurgischen Patienten mit präoperativer Erhebung potenzieller Risikofaktoren und zweifach täglicher Delirmessung über die ersten 5 postoperativen Tage.

Ergebnisse 13 % der Patienten erlitten ein Delir. Verminderte kognitive Leistungsfähigkeit (OR: 3,80; 95 %-KI: 1,66 – 8,66), höhere Komorbidität (OR: 1,36; 95 %-KI: 1,07 – 1,73) und höheres Alter (OR: 1,08; 95 %-KI: 1,02 – 1,13) konnten als Risikofaktoren für ein Delir ermittelt werden.

Schlussfolgerung Ein Delir nach Herzoperation ist häufig. Insbesondere kognitiv eingeschränkte, kränkere, ältere Patienten sind betroffen.

Summary

Background Delirium is a common psychiatric disorder after cardiac surgery and predisposes patients to increased mortality and morbidity. Its prevention requires knowledge of the risk factors involved.

Objective What are preoperative risk factors for postoperative delirium after cardiac surgery?

Methods Prospective longitudinal study of 241 elective cardiac surgical patients with preoperative assessment of potential risk factors and delirium assessment twice daily over five postoperative days.

Results 13 % of the patients experienced delirium. Reduced cognitive performance (OR: 3.80; 95 % CI: 1.66 – 8.66), higher comorbidity (OR: 1.36; 95 % CI: 1.07 – 1.7) and higher age (OR: 1.08; 95 % CI: 1.02 – 1.13) increased the risk of delirium.

Conclusion Delirium after cardiac surgery is common. It occurs in particular in patients with low cognitive performance, higher comorbidity and higher age.

 
  • Literatur

  • 1 Young J. Inouye SK. Delirium in older people. BMJ 2007; 334: 842-846
  • 2 von Haken R. Gruss M. Plaschke K. et al. Delir auf der Intensivstation. Anaesthesist 2010; 59: 235-247
  • 3 Wetterling T. Psychische und psychosomatische Störungen bei Intensivpatienten. In: Die Intensivmedizin. Springer: Berlin [u. a.]; 2015: 597-603
  • 4 ICD-10-GM-2015. http://www.dimdi.de/dynamic/de/klassi/downloadcenter/icd-10-gm/version2015/systematik/
  • 5 Inouye SK. Westendorp RG. Saczynski JS. Delirium in elderly people. Lancet 2013; 383: 911-922
  • 6 Ely EW. Shintani A. Truman B. et al. Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit. JAMA 2004; 291: 1753-1762
  • 7 Ouimet S. Kavanagh BP. Gottfried SB. et al. Incidence, risk factors and consequences of ICU delirium. Intensive Care Med 2007; 33: 66-73
  • 8 O'Keeffe S. Lavan J. The prognostic significance of delirium in older hospital patients. J Am Geriatr Soc 1997; 45: 174-178
  • 9 Davis DHJ. Muniz Terrera G. Keage H. et al. Delirium is a strong risk factor for dementia in the oldest-old: a population-based cohort study. Brain 2012; 135: 2809-2816
  • 10 Wade D. Hardy R. Howell D. et al. Identifying clinical and acute psychological risk factors for PTSD after critical care: a systematic review. Minerva Anestesiol 2013; 79: 944-963
  • 11 Kratz T. Heinrich M. Schlauß E. et al. Preventing postoperative delirium. Dtsch Arztebl Int 2015; 112: 289-296
  • 12 Inouye SK. Bogardus ST. Charpentier PA. et al. A multicomponent intervention to prevent delirium in hospitalized older patients. N Engl J Med 1999; 340: 669-676
  • 13 Barr J. Fraser GL. Puntillo K. et al. Clinical practice guidelines for the management of pain, agitation, and delirium in adult patients in the Intensive Care Unit: executive summary. Am J Health Syst Pharm 2013; 70: 53-58
  • 14 Lin Y. Chen J. Wang Z. Meta-analysis of factors which influence delirium following cardiac surgery. J Card Surg 2012; 27: 481-492
  • 15 Sessler CN. Gosnell MS. Grap MJ. et al. The Richmond Agitation-Sedation Scale: validity and reliability in adult intensive care unit patients. Am J Respir Crit Care Med 2002; 166: 1338-1344
  • 16 Buysse DJ. Reynolds CF. Monk TH. et al. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res 1989; 28: 193-213
  • 17 Backhaus J. Junghanns K. Broocks A. et al. Test-retest reliability and validity of the Pittsburgh Sleep Quality Index in primary insomnia. J Psychosom Res 2002; 53: 737-740
  • 18 Buysse DJ. Reynolds CF. Monk TH. Quantification of subjective sleep quality in healthy elderly men and women using the Pittsburgh Sleep Quality Index (PSQI). Sleep 1991; 14: 331-338
  • 19 Tarlov AR. Ware JE. Greenfield S. The Medical Outcomes Study. An application of methods for monitoring the results of medical care. JAMA 1989; 262: 925-930
  • 20 Rumpf HJ. Meyer C. Hapke U. Screening for mental health: validity of the MHI-5 using DSM-IV Axis I psychiatric disorders as gold standard. Psychiatry Res 2001; 105: 243-253
  • 21 Troyer AK. DemTect effective in screening for mild cognitive impairment and mild dementia. Evid Based Ment Health 2004; 7: 70
  • 22 Deyo RA. Cherkin DC. Ciol MA. Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. J Clin Epidemiol 1992; 45: 613-619
  • 23 Kazmierski J. Kowman M. Banach M. et al. Incidence and predictors of delirium after cardiac surgery: Results from The IPDACS Study. J Psychosom Res 2010; 69: 179-185
  • 24 Stransky M. Schmidt C. Ganslmeier P. et al. Hypoactive delirium after cardiac surgery as an independent risk factor for prolonged mechanical ventilation. J Cardiothorac Vasc Anesth 2011; 25: 968-974
  • 25 Robinson TN. Raeburn CD. Tran ZV. et al. Postoperative delirium in the elderly: risk factors and outcomes. Ann Surg 2009; 249: 173-178
  • 26 Smulter N. Lingehall HC. Gustafson Y. et al. Delirium after cardiac surgery: incidence and risk factors. Interact Cardiovasc Thorac Surg 2013; 17: 790-796
  • 27 Klugkist M. Sedemund-Adib B. Schmidtke C. et al. Confusion Assessment Method for the Intensive Care Unit (CAM-ICU): diagnostik des postoperativen delirs bei kardiochirurgischen Patienten. Anaesthesist 2008; 57: 464-474
  • 28 Morandi A. Davis D. Bellelli G. et al. The Diagnosis of Delirium Superimposed on Dementia: An Emerging Challenge. J Am Med Dir Assoc 2017; 18: 12-18
  • 29 DGAI D. S3-Leitlinie Analgesie, Sedierung und Delirmanagement in der Intensivstation. 2015 http://www.awmf.org/uploads/tx_szleitlinien/001-012l_S3_Analgesie_Sedierung_Delirmanagement_Intensivmedizin_2015-08_01.pdf Accessed 21 Jan 2016
  • 30 Taggart DP. Westaby S. Neurological and cognitive disorders after coronary artery bypass grafting. Curr Opin Cardiol 2001; 16: 271-276
  • 31 Devlin JW. Brummel NE. Al-Qadheeb NS. Optimising the recognition of delirium in the intensive care unit. Best Pract Res Clin Anaesthesiol 2012; 26: 385-393