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DOI: 10.1055/s-0043-102605
Effekte unterschiedlicher sporttherapeutischer Trainingsmethoden bei Patienten mit Herzinsuffizienz – ein Review
Publication History
Eingegangen: 04 January 2017
Angenommen durch Review: 17 January 2017
Publication Date:
11 April 2017 (online)
Zusammenfassung
Hintergrund und Ziel: Aktuell bestehen lediglich Empfehlungen für ein aerobes Ausdauertraining sowie Muskelaufbautraining für die sporttherapeutische Behandlung von Patienten mit Herzinsuffizienz. Aus diesem Grund ist das Ziel dieses Reviews einen Überblick zu den sporttherapeutischen Trainingsmethoden bei Patienten mit Herzinsuffizienz zu geben, um den aktuellen Stand der Forschung aufzuzeigen und Empfehlungen zur Therapie von Patienten mit Herzinsuffizienz abzuleiten.
Methode: Hierfür wurden mittels einer systematischen Literaturrecherche in den Datenbanken Pubmed, Sciencedirect, Web of Science und Scopus Studien im Zeitraum von 1991 bis April 2015 mit einer Kombination aus Schlagwörtern gesucht. Es wurden randomisierte kontrollierte Studien gesammelt, die an Land durchgeführt wurden, sich auf den Menschen und auf das körperlich-sportliche Training beziehen. Ein wichtiger Schwerpunkt bei der Aufbereitung der einzelnen Interventionen lag auf der Betrachtung der Intervention, des Belastungsprotokolls, der Eingangsdiagnostik, der Interventionsdauer sowie der Trainingsumgebung der Studien.
Ergebnis: Nach Sortierung anhand der Kriterien blieben 135 Studien zur Analyse übrig. Der Bereich der Ausdauerinterventionen ist gut untersucht. Im Bereich des Kraft-, Intervall- und Atemmuskeltraining bedarf es noch weiterer Untersuchungen. Ebenso verhält es sich bei den kombinierten Trainingsmethoden. Es fehlen in allen Bereichen Kurzzeitinterventionen (Interventionsdauer < 6 Wochen), um die Effekte auf Rehabilitationsmaßnahmen übertragen zu können.
Diskussion: Abschließend lässt sich sagen, dass im Moment die Wirkungsweisen der unterschiedlichen sporttherapeutischen Trainingsmethoden lediglich im Bereich der Ausdauerinterventionen bewertet werden können. Kraft-, Intervall- sowie inspiratorisches Atemmuskeltraining (IMT) und kombinierte Trainingsmethoden können noch nicht ausreichend beurteilt werden, da Lücken in der Quantität und Qualität bei der Durchführung der einzelnen Studien bestehen.
Summary
Effects of different sports-therapeutic training methods on patients with heart failure: A review
Background and objective: Currently there are only recommendations for an aerobic endurance training as well as muscle building training for the sport-therapeutic treatment of patients with heart failure. On this basis, it is the objective of this article to provide an overview of sport-therapeutic training methods for patients with heart failure in order to show the current state of research and derive recommendations for future therapy of the patients.
Method: This study was carried out by means of systematic literature search with a combination of specific keywords in PubMed, ScienceDirect, Scopus, and Web of science databases encompassing the period 1991 to April 2015. Randomized controlled trials were carried out on land targeting humans and the physical as well as athletic training they undergo. An important focus in the preparation of each specific intervention was the identification of the intervention itself, the stress protocol, the initial diagnosis, the duration of the intervention and the training environment of the studies.
Results: After streamlining the data on the basis of the set-out criteria, 135 studies were selected for analysis. According to the findings, endurance intervention is a topic that has been sufficiently studied. However, intervention measures such as strength, interval and respiratory muscle training require further investigations. The same applies to the combined training methods. Short-term interventions (intervention period < 6 weeks) are still lacking in all intervention areas to enable transfer of the effects to rehabilitation measures.
Discussion: Conclusively, it can be pointed out that hitherto, the effects of the different sports therapeutic training methods could only be evaluated with regard to endurance interventions. Strength, interval as well as inspiratory muscle training (IMT) and combined training methods could not be adequately assessed due to the gaps in the quantity and quality of the implementation of the available individual studies.
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Literatur
- 1 Statistisches Bundesamt. Staat & Gesellschaft – Todesursachen – Die 10 häufigsten Todesursachen. Statistisches Bundesamt (Destatis) (11.12.2014). Im Internet: www.destatis.de/DE/ZahlenFakten/GesellschaftStaat/ Gesundheit/Todesursachen/Tabellen/HaeufigsteTodesursachen.html Stand: 21.04.2015
- 2 Deutsche Gesellschaft für Kardiologie – Herz- und Kreislaufforschung e.V. (Hrsg.). ESC Pocket Guidelines – Herzinsuffizienz Leitlinien für die Diagnose und Behandlung der akuten und chronischen Herzinsuffizienz. Düsseldorf: Deutsche Gesellschaft für Kardiologie – Herz- und Kreislaufforschung e.V.; 2013
- 3 Schmidt RF, Lang F, Heckmann M. (Hrsg.) Physiologie des Menschen. 31.. Aufl. Heidelberg: Springer-Medizin-Verlag; 2010
- 4 Bjarnason-Wehrens B, Graf C. Neue Wege des Trainings in der kardiologischen Rehabilitation. Blickpunkt der Mann 2006; 4 (4): 10-16
- 5 Eder B, Hofmann P, Hödl R. Ist die kardiale Rehabilitation beim alten Menschen noch effektiv?. Journal für Kardiologie 2013; 20 (9-10): 262-268
- 6 Weinbrenner S, Langer T, Scherer M. et al. Nationale VersorgungsLeitlinie Chronische Herzinsuffizienz. Deutsche medizinische Wochenschrift DOI: 10.1055/s-0031-1292894.
- 7 Schwan U. Training mit Herzpatienten. Bewegungstherapie und Gesundheitssport 2009; 25: 108-116
- 8 Deutsche Rentenversicherung Bund. Reha-Therapiestandards Koronare Herzkrankheit: Für die medizinische Rehabilitation der Rentenversicherung. Berlin: (März 2016). Im Internet: www.deutsche-rentenversicherung.de/Allgemein/de/Inhalt/3_Infos_fuer_Experten/01_sozialmedizin_forschung/downloads/quali_rehatherapiestandards/KHK/rts_khk_download.pdf?__blob=publicationFile&v=18
- 9 Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med DOI: 10.1371/journal.pmed.1000097.
- 10 Neubold S, Hülsmann M. Herzinsuffizienz. Wiener Klinische Wochenschrift 2008; (1): 17-33
- 11 Edelmann F, Grabs V, Halle M. Trainingstherapie bei Herzinsuffizienz. Internist (Berl) DOI: 10.1007/s00108-013-3429-y.
- 12 Fünten K aus der, Faude O, Skorski S, Meyer T. Sportmedizin. In: Güllich A, Krüger M. (Hrsg.) Sport: Das Lehrbuch für das Sportstudium. Berlin: Springer; 2013: 171-210
- 13 Meyer K, Peters K, Roskamm H. Verbesserung der aeroben Kapazität bei chronischer Herzinsuffizienz. Z Kardiol 1998; 87: 8-14
- 14 Hottenrott K, Hoos O. Sportmotorische Fähigkeiten und sportliche Leistungen – Trainingswissenschaft. In: Güllich A, Krüger M. (Hrsg.) Sport: Das Lehrbuch für das Sportstudium. Berlin: Springer; 2013
- 15 Mayhew JL, Kerksick CD, Lentz D. et al. Using Repetitions to Fatigue to Predict One-Repetition Maximum Bench Press in Male High School Athletes. Pediatric Exercise Science 2004; 16: 265-276
- 16 Crisafulli E, Costi S, Fabbri LM, Clini EM. Respiratory muscle training in COPD patients. International Journal of COPD 2007; 2 (1): 19-25
- 17 Göhl O, Kabitz HJ. Methodik des Inspirationsmuskeltrainings bei COPD. In: Schulz K, Lichtenschopf A, Frey M. (Hrsg.) Trainingstherapie bei COPD. München-Deisenhofen: Dustri-Verlag Feistle; 2012: 91-110
- 18 Myers J, Hadley D, Oswald U. et al. Effects of exercise training on heart rate recovery in patients with chronic heart failure. Am Heart J DOI: 10.1016/j.ahj.2007.02.038.
- 19 Belardinelli R, Muçaj A, Lacalaprice F. et al. Coenzyme Q10 and exercise training in chronic heart failure. Eur Heart J DOI: 10.1093/eurheartj/ehl158.
- 20 Gielen S, Adams V, Linke A. et al. Exercise training in chronic heart failure: correlation between reduced local inflammation and improved oxidative capacity in the skeletal muscle. European Journal of Cardiovascular Prevention & Rehabilitation DOI: 10.1097/01.hjr.0000174824.94892.43.
- 21 Gielen S, Adams V, Möbius-Winkler S. et al. Anti-inflammatory effects of exercise training in the skeletal muscle of patients with chronic heart failure. J Am Coll Cardiol DOI: 10.1016/S0735-1097(03)00848-9.
- 22 Hambrecht R, Fiehn E, Weigl C. et al. Regular Physical Exercise Corrects Endothelial Dysfunction and Improves Exercise Capacity in Patients With Chronic Heart Failure. Circulation DOI: 10.1161/01.CIR.98.24.2709.
- 23 Dubach P, Myers J, Dziekan G. et al. Effect of High Intensity Exercise Training on Central Hemodynamic Responses to Exercise in Men with Reduced Left Ventricular Function J Am Coll Cardiol DOI: 10.1016/S0735-1097(97)82540-5.
- 24 Hambrecht R, Niebauer J, Fiehn E. et al. Physical training in patients with stable chronic heart failure: Effects on cardiorespiratory fitness and ultrastructural abnormalities of leg muscles. J Am Coll Cardiol DOI: 10.1016/0735-1097(94)00568-B.
- 25 Coats AJ, Adamopoulos S, Radaelli A. et al. Controlled trial of physical training in chronic heart failure. Exercise performance, hemodynamics, ventilation, and autonomic function. Circulation DOI: 10.1161/01.CIR.85.6.2119.
- 26 Kitzman DW, Brubaker PH, Herrington DM. et al. Effect of endurance exercise training on endothelial function and arterial stiffness in older patients with heart failure and preserved ejection fraction: a randomized, controlled, single-blind trial. J Am Coll Cardiol DOI: 10.1016/j.jacc.2013.04.033.
- 27 Belardinelli R, Georgiou D, Cianci G, Purcaro A. 10-year exercise training in chronic heart failure: a randomized controlled trial. J Am Coll Cardiol DOI: 10.1016/j.jacc.2012.06.036.
- 28 Haykowsky MJ, Brubaker PH, Stewart KP. et al. Effect of endurance training on the determinants of peak exercise oxygen consumption in elderly patients with stable compensated heart failure and preserved ejection fraction. J Am Coll Cardiol DOI: 10.1016/j.jacc.2012.02.055.
- 29 Smart NA, Haluska B, Jeffriess L, Leung D. Exercise training in heart failure with preserved systolic function: a randomized controlled trial of the effects on cardiac function and functional capacity. Congestive heart failure DOI: 10.1111/j.1751-7133.2012.00295.x..
- 30 Nishi I, Noguchi T, Iwanaga Y. et al. Effects of Exercise Training in Patients With Chronic Heart Failure and Advanced Left Ventricular Systolic Dysfunction Receiving β-Blockers. Circ J DOI: 10.1253/circj.CJ-10-0899.
- 31 Kitzman DW, Brubaker PH, Morgan TM. et al. Exercise training in older patients with heart failure and preserved ejection fraction: a randomized, controlled, single-blind trial. Circ Heart Fail; DOI: 10.1161/CIRCHEARTFAILURE.110.958785.
- 32 Freimark D, Shechter M, Schwamenthal E. et al. Improved exercise tolerance and cardiac function in severe chronic heart failure patients undergoing a supervised exercise program. Int J Cardiol DOI: 10.1016/j.ijcard.2006.03.021.
- 33 Giannuzzi P, Temporelli PL, Corrà U, Tavazzi L. Antiremodeling effect of long-term exercise training in patients with stable chronic heart failure: results of the Exercise in Left Ventricular Dysfunction and Chronic Heart Failure (ELVD-CHF) Trial. Circulation DOI: 10.1161/01.CIR.0000081780.38477.FA.
- 34 Mueller L, Myers J, Kottman W. et al. Exercise capacity, physical activity patterns and outcomes six years after cardiac rehabilitation in patients with heart failure. Clin Rehabil DOI: 10.1177/0269215507079097.
- 35 Belardinelli R, Lacalaprice F, Faccenda E. et al. Effects of short-term moderate exercise training on sexual function in male patients with chronic stable heart failure. Int J Cardiol DOI: 10.1016/j.ijcard.2004.05.020.
- 36 Piña IL, Bittner V, Clare RM. et al. Effects of exercise training on outcomes in women with heart failure: analysis of HF-ACTION (Heart Failure-A Controlled Trial Investigating Outcomes of Exercise TraiNing) by sex. JACC Heart Fail DOI: 10.1016/j.jchf.2013.10.007.
- 37 Beckers PJ, Denollet J, Possemiers NM. et al. Maintaining physical fitness of patients with chronic heart failure: a randomized controlled trial. European journal of cardiovascular prevention and rehabilitation DOI: 10.1097/HJR.0b013e328339ccac.
- 38 Carvalho VO, Ciolac EG, Guimarães GV, Bocchi EA. Effect of exercise training on 24-hour ambulatory blood pressure monitoring in heart failure patients. Congestive heart failure DOI: 10.1111/j.1751-7133.2009.00093.x.
- 39 Passino C, Del Ry S, Severino S. et al. C-type natriuretic peptide expression in patients with chronic heart failure: effects of aerobic training. European journal of cardiovascular prevention and rehabilitation DOI: 101097/HJR.0b013e3282f10e9b.
- 40 Conraads V, Vanderheyden M, Paelinck B. et al. The effect of endurance training on exercise capacity following cardiac resynchronization therapy in chronic heart failure patients: a pilot trial. European journal of cardiovascular prevention and rehabilitation DOI: 10.1097/HJR.0b013e32801164b3.
- 41 Yamamoto U, Mohri M, Shimada K. et al. Six-month aerobic exercise training ameliorates central sleep apnea in patients with chronic heart failure. J Card Fail DOI: 10.1016/j.cardfail.2007.08.001.
- 42 Belardinelli R, Capestro F, Misiani A. et al. Moderate exercise training improves functional capacity, quality of life, and endothelium-dependent vasodilation in chronic heart failure patients with implantable cardioverter defibrillators and cardiac resynchronization therapy. European journal of cardiovascular prevention and rehabilitation DOI: 10.1097/01.hjr.0000230104.93771.7d.
- 43 Maria Sarullo F, Gristina T, Brusca I. et al. Effect of physical training on exercise capacity, gas exchange and N-terminal pro-brain natriuretic peptide levels in patients with chronic heart failure. European journal of cardiovascular prevention and rehabilitation DOI: 10.1097/01.hjr.0000238396.42718.61.
- 44 Malfatto G, Branzi G, Riva B. et al. Recovery of cardiac autonomic responsiveness with low-intensity physical training in patients with chronic heart failure. Eur J Heart Fail DOI: 10.1016/S1388-9842(01)00221-5.
- 45 European Heart Failure Training Group. Experience from controlled trials of physical training in chronic heart failure. Protocol and patient factors in effectiveness in the improvement in exercise tolerance. Eur Heart J DOI: 10.1053/euhj.1997.0736.
- 46 Kavanagh T, Myers MG, Baigrie RS. et al. Quality of life and cardiorespiratory function in chronic heart failure: effects of 12 months’ aerobic training. Heart DOI: 10.1136/hrt.76.1.42.
- 47 Belardinelli R, Georgiou D, Scocco V. et al. Low intensity exercise training in patients with chronic heart failure. J Am Coll Cardiol DOI: 10.1016/0735-1097(95)00267-1.
- 48 Niebauer J, Clark AL, Webb-Peploe KM. et al. Home-based exercise training modulates pro-oxidant substrates in patients with chronic heart failure. Eur J Heart Fail DOI: 10.1016/j.ejheart.2004.06.001.
- 49 Gielen S, Sandri M, Kozarez I. et al. Exercise training attenuates MuRF-1 expression in the skeletal muscle of patients with chronic heart failure independent of age: the randomized Leipzig Exercise Intervention in Chronic Heart Failure and Aging catabolism study. Circulation DOI: 10.1161/CIRCULATIONAHA.111.047381.
- 50 Wielenga RP, Huisveld IA, Bol E. et al. Safety and effects of physical training in chronic heart failure. Results of the Chronic Heart Failure and Graded Exercise study (CHANGE). Eur Heart J DOI: 10.1053/euhj.1999.1485.
- 51 Keyhani D, Kargarfard M, Sarrafzadegan N, Sadeghi M. Autonomic function change following a supervised exercise program in patients with congestive heart failure. ARYA Atherosclerosis 2013; 9 (2): 150-156
- 52 Harjola V-P, Kiilavuori K, Virkamäki A. The effect of moderate exercise training on skeletal muscle myosin heavy chain distribution in chronic heart failure. Int J Cardiol DOI: 10.1016/j.ijcard.2005.06.025.
- 53 Tyni-Lenné R, Gordon A, Sylvén C. Improved quality of life in chronic heart failure patients following local endurance training with leg muscles. J Card Fail DOI: 10.1016/S1071-9164(96)80029-7.
- 54 Brubaker PH, Moore JB, Stewart KP. et al. Endurance exercise training in older patients with heart failure: results from a randomized, controlled, single-blind trial. J Am Geriatr Soc DOI: 10.1111/j.1532-5415.2009.02499.x.
- 55 Kiilavuori K, Näveri H, Salmi T, Härkönen M. The effect of physical training on skeletal muscle in patients with chronic heart failure. Eur J Heart Fail DOI: 10.1016/S1388-9842(00)00058-1.
- 56 Nishiyama Y, Minohara M, Ohe M. et al. Effect of Physical Training on Insulin Resistance in Patients With Chronic Heart Failure. Circ J DOI: 10.1253/circj.70.864.
- 57 Gary RA, Sueta CA, Dougherty M. et al. Home-based exercise improves functional performance and quality of life in women with diastolic heart failure. Heart &Lung DOI: 10.1016/j.hrtlng.2004.01.004.
- 58 Tsarouhas K, Karatzaferi C, Tsitsimpikou C. et al. Effects of walking on heart rate recovery, endothelium modulators and quality of life in patients with heart failure. Eur J Cardiovasc Prev Rehabil DOI: 10.1177/1741826710397099.
- 59 Wielenga RP, Erdman RA, Huisveld IA. et al. Effect of exercise training on quality of life in patients with chronic heart failure. Journal of Psychosomatic Research DOI: 10.1016/S0022-3999(97)00309-7.
- 60 Kiilavuori K. Effect of Physical Training on Exercise Capacity and Gas Exchange in Patients With Chronic Heart Failure. CHEST DOI: 10.1378/chest.110.4.985.
- 61 Linke A, Schoene N, Gielen S. et al. Endo-thelial dysfunction in patients with chronic heart failure: systemic effects of lower-limb exercise training. J Am Coll Cardiol DOI: 10.1016/S0735-1097(00)01108-6.
- 62 Larsen AI, Aukrust P, Aarsland T, Dick-stein K. Effect of aerobic exercise training on plasma levels of tumor necrosis factor alpha in patients with heart failure. The American Journal of Cardiology DOI: 10.1016/S0002-9149(01)01859-8.
- 63 Sandri M, Kozarez I, Adams V. et al. Age-related effects of exercise training on diastolic function in heart failure with reduced ejection fraction: the Leipzig Exercise Intervention in Chronic Heart Failure and Aging (LEICA) Diastolic Dysfunction Study. Eur Heart J DOI: 10.1093/eurheartj/ehr469.
- 64 Levinger I, Bronks R, Cody DV. et al. Resistance training for chronic heart failure patients on beta blocker medications. Int J Cardiol DOI: 10.1016/j.ijcard.2004.05.061.
- 65 Tyni-Lenné R, Dencker K, Gordon A. et al. Comprehensive local muscle training increases aerobic working capacity and quality of life and decreases neurohormonal activation in patients with chronic heart failure. Eur J Heart Fail DOI: 10.1016/S1388-9842(00)00087-8.
- 66 Williams AD, Carey MF, Selig S. et al. Circuit resistance training in chronic heart failure improves skeletal muscle mitochondrial ATP production rate – a randomized controlled trial. J Card Fail DOI: 10.1016/j.cardfail.2006.10.017.
- 67 Selig S, Carey MF, Menzies D. et al. Moderate-intensity resistance exercise training in patients with chronic heart failure improves strength, endurance, heart rate variability, and forearm blood flow. J Card Fail DOI: 10.1016/S1071-9164(03)00583-9.
- 68 Pu C, Johnson M, Forman D. et al. Randomized trial of progressive resistance training to counteract the myopathy of chronic heart failure. Journal of Applied Physiology 2001; 90 (6): 2341-2350
- 69 Toth MJ, Miller MS, Ward KA, Ades PA. Skeletal muscle mitochondrial density, gene expression, and enzyme activities in human heart failure: minimal effects of the disease and resistance training. Journal of Applied Physiology DOI: 10.1152/japplphysiol.01591.2011.
- 70 Owen A, Croucher L. Effect of an exercise programme for elderly patients with heart failure. Eur J Heart Fail DOI: 10.1016/S1388-9842(99)00067-7.
- 71 Savage PA, Shaw AO, Miller MS. et al. Effect of resistance training on physical disability in chronic heart failure. Med Sci Sports Exerc DOI: 10.1249/MSS.0b013e31820eeea1.
- 72 Chrysohoou C, Tsitsinakis G, Vogiatzis I. et al. High intensity, interval exercise improves quality of life of patients with chronic heart failure: a randomized controlled trial. QJM DOI: 10.1093/qjmed/hct194.
- 73 Isaksen K, Munk PS, Valborgland T, Larsen AI. Aerobic interval training in patients with heart failure and an implantable cardioverter defibrillator: a controlled study evaluating feasibility and effect. European Journal of Preventive Cardiology DOI: 10.1177/2047487313519345.
- 74 Huang SC, Wong MK, Lin PJ. et al. Modified high-intensity interval training increases peak cardiac power output in patients with heart failure. Eur J Appl Physiol DOI: 10.1007/s00421-014-2913-y.
- 75 Wang JS, Fu TC, Lien HY. et al. Effect of aerobic interval training on erythrocyte rheological and hemodynamic functions in heart failure patients with anemia. Int J Cardiol DOI: 10.1016/j.ijcard.2012.11.053.
- 76 Willenheimer R, Erhardt L, Cline C. et al. Exercise training in heart failure improves quality of life and exercise capacity. Eur Heart J DOI: 10.1053/euhj.1997.0853.
- 77 Collins E, Langbein WE, Dilan-Koetje J. et al. Effects of exercise training on aerobic capacity and quality of life in individuals with heart failure. Heart & Lung DOI: 10.1016/j.hrtlng.2003.12.009.
- 78 Klecha A, Kawecka-Jaszcz K, Bacior B. et al. Physical training in patients with chronic heart failure of ischemic origin: effect on exercise capacity and left ventricular remodeling. European journal of cardio-vascular prevention and rehabilitation DOI: 10.1097/HJR.0b013e3280114f12.
- 79 Willenheimer R, Rydberg E, Cline C. et al. Effects on quality of life, symptoms and daily activity 6 months after termination of an exercise training programme in heart failure patients. Int J Cardiol DOI: 10.1016/S0167-5273(00)00383-1.
- 80 Palau P, Dominguez E, Nunez E. et al. Effects of inspiratory muscle training in patients with heart failure with preserved ejection fraction. European Journal of Preventive Cardiology DOI: 10.1177/2047487313498832.
- 81 Mello PR, Guerra GM, Borile S. et al. Inspiratory muscle training reduces sympathetic nervous activity and improves inspiratory muscle weakness and quality of life in patients with chronic heart failure: a clinical trial. J Cardiopulm Rehabil Prev DOI: 10.1097/HCR.0b013e31825828da.
- 82 Laoutaris I, Dritsas A, Brown MD. et al. Inspiratory muscle training using an incremental endurance test alleviates dyspnea and improves functional status in patients with chronic heart failure. European Journal of Cardiovascular Prevention & Rehabilitation DOI: 10.1097/01.hjr.0000152242.51327.63.
- 83 Johnson P, Cowley AJ, Kinnear W. A randomized controlled trial of inspiratory muscle training in stable chronic heart failure. Eur Heart J DOI: 10.1053/euhj.1998.1024.
- 84 Marco E, Ramírez-Sarmiento AL, Coloma A. et al. High-intensity vs. sham inspiratory muscle training in patients with chronic heart failure: a prospective randomized trial Eur J Heart Fail DOI: 10.1093/eurjhf/hft035.
- 85 Bosnak-Guclu M, Arikan H, Savci S. et al. Effects of inspiratory muscle training in patients with heart failure. Respir Med DOI: 10.1016/j.rmed.2011.05.001.
- 86 Dall’Ago P, Chiappa GR S, Guths H. et al. Inspiratory muscle training in patients with heart failure and inspiratory muscle weakness: a randomized trial. J Am Coll Cardiol DOI: 10.1016/j.jacc.2005.09.052.
- 87 Borland M, Rosenkvist A, Cider A. A group-based exercise program did not improve physical activity in patients with chronic heart failure and comorbidity: a randomized controlled trial. J Rehabil Med DOI: 10.2340/16501977-1794.
- 88 Gary RA, Cress ME, Higgins MK. et al. A combined aerobic and resistance exercise program improves physical func-tional performance in patients with heart failure: a pilot study. J Cardiovasc Nurs DOI: 10.1097/JCN.0b013e31822ad3c3.
- 89 Gary RA, Cress ME, Higgins MK. et al. Combined aerobic and resistance exercise program improves task performance in patients with heart failure. Arch Phys Med Rehabil DOI: 10.1016/j.apmr.2011.02.022.
- 90 Edelmann F, Gelbrich G, Düngen HD. et al. Exercise training improves exercise capacity and diastolic function in patients with heart failure with preserved ejection fraction: results of the Ex-DHF (Exercise training in Diastolic Heart Failure) pilot study. J Am Coll Cardiol DOI: 10.1016/j.jacc.2011.06.054.
- 91 Evangelista LS, Hamilton MA, Fonarow GC, Dracup K. Is exercise adherence associated with clinical outcomes in patients with advanced heart failure?. Phys Sportsmed DOI: 10.3810/psm2010.04.1759.
- 92 Bocalini DS, Santos LD, Serra AJ. Physical exercise improves the functional capacity and quality of life in patients with heart failure. Clinics DOI: 10.1590/S1807-59322008000400005.
- 93 Yu D, Lee D, Woo J, Hui E. Non-pharmacological interventions in older people with heart failure: effects of exercise training and relaxation therapy. Gerontology DOI: 10.1159/000096427.
- 94 de Mello FF G, Santos AC, Rondon MU P. et al. Effects of home-based exercise training on neurovascular control in patients with heart failure. Eur J Heart Fail DOI: 10.1016/j.ejheart.2006.02.009.
- 95 Austin J, Williams R, Ross L. et al. Randomised controlled trial of cardiac rehabilitation in elderly patients with heart failure. Eur J Heart Fail DOI: 10.1016/j.ejheart.2004.10.004.
- 96 Jónsdóttir S, Andersen KK, Sigurosson AF, Sigurosson SB. The effect of physical training in chronic heart failure. Eur J Heart Fail DOI: 10.1016/j.ejheart.2005.05.002.
- 97 Pozehl B, Duncan K, Hertzog M, Norman JF. Heart Failure Exercise And Training Camp: effects of a multicomponent exercise training intervention in patients with heart failure. Heart & Lung DOI: 10.1016/j.hrtlng.2010.04.008.
- 98 Tyni-Lenné R, Gordon A, Jansson E. et al. Skeletal muscle endurance training improves peripheral oxidative capacity, exercise tolerance, and health-related quality of life in women with chronic congestive heart failure secondary to either ischemic cardiomyopathy or idiopathic dilated cardiomyopathy. The American Journal of Cardiology DOI: 10.1016/S0002-9149(97)00597-3.
- 99 Nolte K, Herrmann-Lingen C, Wachter R. et al. Effects of exercise training on different quality of life dimensions in heart failure with preserved ejection fraction: The Ex-DHF-P trial. European Journal of Preventive Cardiology DOI: 10.1177/2047487314526071.
- 100 Meirelles LRd, Matsuura C, Resende AdC. et al. Chronic exercise leads to antiaggregant, antioxidant and anti-inflammatory effects in heart failure patients. European Journal of Preventive Cardiology DOI: 10.1177/2047487313491662.
- 101 Santos J, Kowatsch I, Tsutsui J. et al. Effects of exercise training on myocardial blood flow reserve in patients with heart failure and left ventricular systolic dysfunction. The American Journal of Cardiology DOI: 10.1016/j.amjcard.2009.09.009.
- 102 Antunes-Correa LM, Melo RC, Nobre TS. et al. Impact of gender on benefits of exercise training on sympathetic nerve activity and muscle blood flow in heart failure. Eur J Heart Fail DOI: 10.1093/eurjhf/hfp168.
- 103 Fraga R, Franco FG, Roveda F. et al. Exercise training reduces sympathetic nerve activity in heart failure patients treated with carvedilol. Eur J Heart Fail DOI: 10.1016/j.ejheart.2007.03.003.
- 104 Niebauer J, Clark AL, Webb-Peploe KM, Coats AJS. Exercise training in chronic heart failure: effects on pro-inflammatory markers. Eur J Heart Fail DOI: 10.1016/j.ejheart.2004.07.012.
- 105 Roveda F, Middlekauff HR, Rondon M. et al. The effects of exercise training on sympathetic neural activation in advanced heart failure. J Am Coll Cardiol DOI: 10.1016/S0735-1097(03)00831-3.
- 106 Stevens AL M, Hansen D, Herbots L. et al. Exercise training improves insulin release during glucose tolerance testing in stable chronic heart failure patients. J Cardiopulm Rehabil Prev DOI: 10.1097/HCR.0000000000000092.
- 107 Silva MS, Bocchi E, Guimarães G. et al. Benefits of exercise training in the treatment of heart failure: study with a control group. Arq Bras Cardiol DOI: 10.1590/S0066-782X2002001300003.
- 108 Norman JF, Pozehl BJ, Duncan KA. et al. Effects of Exercise Training versus Attention on Plasma B-type Natriuretic Peptide, 6-Minute Walk Test and Quality of Life in Individuals with Heart Failure. Cardiopulmonary Physical Therapy Journal 2012; 23 (4): 19-25
- 109 Pihl E, Cider A, Strömberg A, Fridlund B, Mårtensson J. Exercise in elderly patients with chronic heart failure in primary care: effects on physical capacity and health-related quality of life. European journal of cardiovascular nursing DOI: 10.1016/j.ejcnurse.2011.03.002.
- 110 Prescott E, Hjardem-Hansen R, Dela F. et al. Effects of a 14-month low-cost maintenance training program in patients with chronic systolic heart failure: a randomized study. European journal of cardio-vascular prevention and rehabilitation DOI: 10.1097/HJR.0b013e32831e94f8.
- 111 Maiorana AJ, Naylor LH, Exterkate A. et al. The impact of exercise training on conduit artery wall thickness and remodeling in chronic heart failure patients. Hypertension DOI: 10.1161/HYPERTENSIONAHA.110.163022.
- 112 Servantes DM, Pelcerman A, Salvetti XM. et al. Effects of home-based exercise training for patients with chronic heart failure and sleep apnoea: a randomized comparison of two different programmes. Clin Rehabil DOI: 10.1177/0269215511403941.
- 113 Mandic S, Tymchak W, Kim D. et al. Effects of aerobic or aerobic and resistance training on cardiorespiratory and skeletal muscle function in heart failure: a randomized controlled pilot trial. Clin Rehabil DOI: 10.1177/0269215508095362.
- 114 Feiereisen P, Delagardelle C, Vaillant M. et al. Is strength training the more efficient training modality in chronic heart failure?. Med Sci Sports Exerc DOI: 10.1249/mss.0b013e31814fb545.
- 115 Belardinelli R, Lacalaprice F, Ventrella C. et al. Waltz dancing in patients with chronic heart failure: new form of exercise training. Circ Heart Fail DOI: 10.1161/CIRCHEARTFAILURE.108.765727.
- 116 Kaltsatou A, Kouidi EI, Anifanti MA. et al. Functional and psychosocial effects of either a traditional dancing or a formal exercising training program in patients with chronic heart failure: a comparative randomized controlled study. Clin Rehabil DOI: 10.1177/0269215513492988.
- 117 Yaylalı YT, Fındıkoğlu G, Yurtdaş M. et al. The effects of baseline heart rate recovery normality and exercise training protocol on heart rate recovery in patients with heart failure. Anatolian journal of cardiology DOI: 10.5152/akd.2014.5710.
- 118 Wisløff U, Støylen A, Loennechen JP. et al. Superior cardiovascular effect of aerobic interval training versus moderate continuous training in heart failure patients: a randomized study. Circulation DOI: 10.1161/CIRCULATIONAHA.106.675041.
- 119 Fu TC, Wang CH, Lin PS. et al. Aerobic interval training improves oxygen uptake efficiency by enhancing cerebral and muscular hemodynamics in patients with heart failure. Int J Cardiol DOI: 10.1016/j.ijcard.2011.11.086.
- 120 Klocek M, Kubinyi A, Bacior B, Kawecka-Jaszcz K. Effect of physical training on quality of life and oxygen consumption in patients with congestive heart failure. Int J Cardiol DOI: 10.1016/j.ijcard.2004.10.021.
- 121 Chrysohoou C, Angelis A, Tsitsinakis G. et al. Cardiovascular effects of high-intensity interval aerobic training combined with strength exercise in patients with chronic heart failure. A randomized phase III clinical trial. Int J Cardiol DOI: 10.1016/j.ijcard.2014.11.067.
- 122 Meyer K, Schwaibold M, Westbrook S. et al. Effects of short-term exercise training and activity restriction on functional capacity in patients with severe chronic congestive heart failure. The American Journal of Cardiology DOI: 10.1016/S0002-9149(96)00527-9.
- 123 Kemps H, de Vries W, Schmikli S. et al. Assessment of the effects of physical training in patients with chronic heart failure: the utility of effort-independent exercise variables. Eur J Appl Physiol DOI: 10.1007/s00421-009-1230-3.
- 124 Nilsson BB, Westheim A, Risberg MA. Effects of group-based high-intensity aerobic interval training in patients with chronic heart failure. The American Journal of Cardiology DOI: 10.1016/j.amjcard.2008.07.016.
- 125 Nilsson BB, Westheim A, Risberg MA. Long-term effects of a group-based high-intensity aerobic interval-training program in patients with chronic heart failure. The American Journal of Cardiology DOI: 10.1016/j.amjcard.2008.06.046.
- 126 Senden PJ, Sabelis LW, Zonderland ML. et al. The effect of physical training on workload, upper leg muscle function and muscle areas in patients with chronic heart failure. Int J Cardiol DOI: 10.1016/j.ijcard.2004.10.039.
- 127 Piccini JP, Hellkamp AS, Whellan DJ. et al. Exercise training and implantable cardioverter-defibrillator shocks in patients with heart failure: results from HF-ACTION (Heart Failure and A Controlled Trial Investigating Outcomes of Exercise TraiNing). JACC Heart Fail DOI: 10.1016/j.jchf.2013.01.005.
- 128 Blumenthal JA, Babyak MA, O’Connor C. et al. Effects of exercise training on depressive symptoms in patients with chronic heart failure: the HF-ACTION randomized trial. JAMA DOI: 10.1001/jama.2012.8720.
- 129 O’Connor CM, Whellan DJ, Lee KL. et al. Efficacy and safety of exercise training in patients with chronic heart failure: HF-ACTION randomized controlled trial. JAMA DOI: 10.1001/jama.2009.454.
- 130 Corvera-Tindel T, Doering LV, Woo MA. et al. Effects of a home walking exercise program on functional status and symptoms in heart failure. Am Heart J DOI: 10.1016/j.ahj.2003.09.007.
- 131 Pozehl B, Duncan K, Hertzog M. The effects of exercise training on fatigue and dyspnea in heart failure. European journal of cardiovascular nursing DOI: 10.1016/j.ejcnurse.2007.08.002.
- 132 Dracup K, Evangelista LS, Hamilton MA. et al. Effects of a home-based exercise program on clinical outcomes in heart failure. Am Heart J DOI: 10.1016/j.ahj.2007.07.019.
- 133 Jones LW, Douglas PS, Khouri mg. et al. Safety and efficacy of aerobic training in patients with cancer who have heart failure: an analysis of the HF-ACTION randomized trial. Journal of clinical oncology DOI: 10.1200/JCO.2013.53.5724.
- 134 Hambrecht R, Hilbrich L, Erbs S. et al. Correction of endothelial dysfunction in chronic heart failure: additional effects of exercise training and oral L-arginine supplementation. J Am Coll Cardiol DOI: 10.1016/S0735-1097(99)00602-6.
- 135 Deutsche Gesellschaft für Prävention und Rehabilitation. Pocket-Leitlinie zur Rehabilitation von Patienten mit Herz-Kreislauferkrankungen. Koblenz: 2008 Im Internet: www.dgpr.de/fileadmin/user_upload/DGPR/Leitlinien/Pocket_Leitlinie_DGPR_HK.pdf
- 136 Lipkin DP, Scriven AJ, Crake T. et al. Six minute walking test for assessing exercise capacity in chronic heart failure. British Medical Journal 1986; 292: 653-655
- 137 Hwang R, Marwick T. Efficacy of home-based exercise programmes for people with chronic heart failure: a meta-analysis. European journal of cardiovascular prevention and rehabilitation DOI: 10.1097/HJR.0b013e32832e097f.
- 138 Höllriegel R, Beck EB, Linke A. et al. Anabolic effects of exercise training in patients with advanced chronic heart failure (NYHA IIIb): impact on ubiquitin-protein ligases expression and skeletal muscle size. Int. J. Cardiol. DOI: 10.1016/j.ijcard.2012.03.083.
- 139 Linke A, Adams V, Schulze PC. et al. Antioxidative effects of exercise training in patients with chronic heart failure: increase in radical scavenger enzyme activity in skeletal muscle. Circulation DOI: 10.1161/01.CIR.0000165503.08661.E5.
- 140 Hambrecht R, Fiehn E, Yu J. et al. Effects of Endurance Training on Mitochondrial Ultrastructure and Fiber Type Distribution in Skeletal Muscle of Patients With Stable Chronic Heart Failure. J Am Coll Cardiol DOI: 10.1016/S0735-1097(97)00015-6.
- 141 Fujimoto N, Prasad A, Hastings JL. et al. Cardiovascular effects of 1 year of progressive endurance exercise training in patients with heart failure with preserved ejection fraction. Am Heart J DOI: 10.1016/j.ahj.2012.06.028.
- 142 Murad K, Brubaker PH, Fitzgerald DM. et al. Exercise training improves heart rate variability in older patients with heart failure: a randomized, controlled, single-blinded trial. Congestive heart failure DOI: 10.1111/j.1751-7133.2011.00282.x.
- 143 Craenenbroeck EM van, Hoymans VY, Beckers PJ. et al. Exercise training improves function of circulating angiogenic cells in patients with chronic heart failure. Basic Res Cardiol DOI: 10.1007/s00395-010-0105-4.
- 144 Belardinelli R, Georgiou D, Cianci G, Purcaro A. Randomized, Controlled Trial of Long-Term Moderate Exercise Training in Chronic Heart Failure: Effects on Functional Capacity, Quality of Life, and Clinical Outcome. Circulation DOI: 10.1161/01.CIR.99.9.1173.
- 145 Erbs S, Linke A, Gielen S. et al. Exercise training in patients with severe chronic heart failure: impact on left ventricular performance and cardiac size. A retrospective analysis of the Leipzig Heart Failure Training Trial. European journal of cardiovascular prevention and rehabilitation DOI: 10.1097/01.hjr.0000099031.38268.27.
- 146 Esposito F, Reese SL van, Wagner PD, Richardson RS. Isolated quadriceps training increases maximal exercise capacity in chronic heart failure: the role of skeletal muscle convective and diffusive oxygen transport. J Am Coll Cardiol DOI: 10.1016/j.jacc.2011.06.025.
- 147 Levinger I, Bronks R, Cody DV, Linton I, Davie A. The effect of resistance training on left ventricular function and structure of patients with chronic heart failure. Int J Cardiol DOI: 10.1016/j.ijcard.2004.11.022.
- 148 Williams AD, Anderson MJ, Selig S. et al. Differential response to resistance training in CHF according to ACE genotype. Int J Cardiol DOI: 10.1016/j.ijcard.2010.02.012.
- 149 Cowie A, Thow MK, Granat MH, Mitchell SL. A comparison of home and hospital-based exercise training in heart failure: immediate and long-term effects upon physical activity level. European journal of cardiovascular prevention and rehabilitation DOI: 10.1177/1741826710389389.
- 150 Ajiboye OA, Anigbogu CN, Ajuluchukwu JN, Jaja SI. Exercise training improves functional walking capacity and activity level of Nigerians with chronic biventricular heart failure. Hong Kong Physiotherapy Journal DOI: 10.1016/j.hkpj.2014.11.002.
- 151 Hagerman I, Tyni-Lenné R, Gordon A. Outcome of exercise training on the long-term burden of hospitalisation in patients with chronic heart failure. A retrospective study. Int J Cardiol DOI: 10.1016/j.ijcard.2003.10.063.
- 152 Koifman E, Grossman E, Elis A, Dicker D. et al. Multidisciplinary rehabilitation program in recently hospitalized patients with heart failure and preserved ejection fraction: rationale and design of a randomized controlled trial. Am Heart J DOI: 10.1016/j.ahj.2014.08.010.
- 153 Oka RK, de Marco T, Haskell WL. et al. Impact of a home-based walking and resistance training program on quality of life in patients with heart failure. The American Journal of Cardiology DOI: 10.1016/S0002-9149(99)00748-1.
- 154 Jolly K, Taylor RS, Lip GY H. et al. A rando-mized trial of the addition of home-based exercise to specialist heart failure nurse care: the Birmingham Rehabilitation Uptake Maximisation study for patients with Congestive Heart Failure (BRUM-CHF) study. Eur J Heart Fail DOI: 10.1093/eurjhf/hfn029.
- 155 Oka RK, DeMarco T, Haskell WL. Effect of treadmill testing and exercise training on self-efficacy in patients with heart failure. European journal of cardiovascular nursing DOI: 10.1016/j.ejcnurse.2005.04.004.
- 156 Berendoncks A van, Beckers P, Hoymans VY. et al. Exercise training reduces circulating adiponectin levels in patients with chronic heart failure. Clinical science DOI: 10.1042/CS20090213.