Exploration of phytochemical content of cultivated Stachys iva Griseb

Genus Stachys L. consists of 300 species as annual or perennial herbs or small shrubs. In terms of phytochemistry, the plants of the genus are rich in constituents with therapeutic and economic applications. In continuation of our research on this genus [1], [2], we report herein, for the first time, the phytochemical investigation of the essential oil (EO) and the dichloromethane-methanol extract of cultivated Stachys iva Griseb., by the means of different analytical techniques. 1D and 2D NMR experiments were used for the identification and characterization of the chemical components of the extract. The EO was obtained by hydrodistillation and was analysed by GC-MS technique. Overall, thirteen compounds were revealed from the studied extract, including two iridoids, two phenylethanoid glycosides, and nine flavonoids. Moreover, a comparative study between the dichloromethane-methanol extract and the previously studied polar extract [2] was conducted. Regarding the chemical content of the EO, the main constituents were geranyl-α-terpinene, caryophyllene oxide and epi-α-bisabolol. In conclusion, the dichloromethane-methanol extract of the cultivated S. iva contains a variety of natural products, with pharmacological interest. As far as we know, this study is the first report on the chemical composition of the EO of the specific species.

Acknowledgment

The Author thanks Special Account for Research Grants and National and Kapodistrian University of Athens for funding to attend the meeting.

• References

• 1 Tomou EM, Barda C, Skaltsa H. Genus Stachys: A Review of Traditional Uses, Phytochemistry and Bioactivity. Medicines 2020; 7: 63
• 2 Pritsas A, Tomou E-M, Tsitsigianni E. et al. Valorisation of stachysetin from cultivated Stachys iva Griseb. as anti-diabetic agent: a multi-spectroscopic and molecular docking approach. J Biomol Struct Dyn 2021; 39: 6452-6466

Publication History

Article published online:
12 December 2022