Planta Med 2022; 88(15): 1464-1465
DOI: 10.1055/s-0042-1759076
Poster Session I

A green methodology for extraction and isolation of squalene as value-added product from refinery by-products

D Michailidis∗
1   PharmaGnose S. A., 57th km Athens-Lamia National Road, 32011, Oinofyta, Greece
,
V Papaioannou
2   Division of Pharmacognosy and Natural Products Chemistry, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimioupoli Zografou, 15771, Athens, Greece
,
G Papaefstathiou
1   PharmaGnose S. A., 57th km Athens-Lamia National Road, 32011, Oinofyta, Greece
,
P Stathopoulos
2   Division of Pharmacognosy and Natural Products Chemistry, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimioupoli Zografou, 15771, Athens, Greece
,
L A Skaltsounis
2   Division of Pharmacognosy and Natural Products Chemistry, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimioupoli Zografou, 15771, Athens, Greece
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Olive Oil by-products are at the center of commercial interest due to their high content in bioactives [1]. Till today, most of the studies have focused on olive leaves, olive mills by-products as well as by-products produced from the debittering process of edible olives while there is only few information available about the refinery residues produced during the olive oil refining process. Specifically, various types of by-products (soap faction obtained after the neutralization treatment, deodorizing by-products, solid waste resulting after demargarinization, acid oil from chemical refining, exhausted bleaching earths after filtration), are produced in Refinery with significant scientific interest due to their bioactive content. Among them, the deodorizing by-products are a valuable source of squalene, a triterpene characterized by an abundance of beneficial effects on human health such as antioxidant activity, tumor inhibitor and skin protective properties. The aim of the present study was the isolation of squalene from deodorizing by-products and the production of squalene-enriched extracts, by applying modern extraction and isolation methodologies such as Centrifugal Partition Chromatography (CPC) and Molecular Short Path Distillation (MSPD). Overall, in the context of the present study, a green-based methodology for squalene – enriched extracts production and high-purity squalene isolation was developed, utilizing the refinery by-products produced during the olive oil deodorization process thereof.

The authors declare no conflict of interest

Funding

The present work was carried out and co-funded by the European-Regional-Development-Fund (ERDF) and Greek national funds through the Operational Program “Competitiveness, Entrepreneurship and Innovation”, under the call “RESEARCH–CREATE-INNOVATE” SQUAKER (project code: 03 553).


 

 

Publication History

Article published online:
12 December 2022

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