Pain Relief and Safety of Microwave Ablation Combined with Percutaneous Vertebroplasty for Vertebral Metastasis: A Pilot Study

Ting-Ye Hu; Gan Zhang; Hong Ye; Cheng-Ling An; Kai Wang; Lei Xia; Xiao-Xing Zhou; Shan-Shan Zhang; Yu-He Lu

doi:10.1055/s-0042-1758121

Journal of Neurological Surgery Part A: Central European Neurosurgery, Table of Contents

J Neurol Surg A Cent Eur Neurosurg 2023; 84(06): 513-520
DOI: 10.1055/s-0042-1758121

Original Article

Pain Relief and Safety of Microwave Ablation Combined with Percutaneous Vertebroplasty for Vertebral Metastasis: A Pilot Study

Ting-Ye Hu

¹Department of Interventional Vascular Surgery, Affiliated Chuzhou Hospital of Anhui Medical University, Chuzhou, Municipal First People's Hospital, Chuzhou, Anhui, China

,

Gan Zhang

²Department of General Surgery, Anhui Hanbo Group Hospital, Chuzhou, Anhui, China

,

Hong Ye

³Department of Orthopedics, Affiliated Chuzhou Hospital of Anhui Medical University, Chuzhou, Municipal First People's Hospital, Chuzhou, Anhui, China

,

Cheng-Ling An

⁴Digital Subtraction Angiography, Affiliated Chuzhou Hospital of Anhui Medical University, Chuzhou, Municipal First People's Hospital, Chuzhou, Anhui, China

,

Kai Wang

¹Department of Interventional Vascular Surgery, Affiliated Chuzhou Hospital of Anhui Medical University, Chuzhou, Municipal First People's Hospital, Chuzhou, Anhui, China

,

Lei Xia

¹Department of Interventional Vascular Surgery, Affiliated Chuzhou Hospital of Anhui Medical University, Chuzhou, Municipal First People's Hospital, Chuzhou, Anhui, China

,

Xiao-Xing Zhou

¹Department of Interventional Vascular Surgery, Affiliated Chuzhou Hospital of Anhui Medical University, Chuzhou, Municipal First People's Hospital, Chuzhou, Anhui, China

,

Shan-Shan Zhang

¹Department of Interventional Vascular Surgery, Affiliated Chuzhou Hospital of Anhui Medical University, Chuzhou, Municipal First People's Hospital, Chuzhou, Anhui, China

,

Yu-He Lu

¹Department of Interventional Vascular Surgery, Affiliated Chuzhou Hospital of Anhui Medical University, Chuzhou, Municipal First People's Hospital, Chuzhou, Anhui, China

› Author Affiliations

Abstract

Background We investigate the pain relief and safety of microwave ablation (MWA) combined with percutaneous vertebroplasty (PVP) in the treatment of metastatic vertebral tumors.

Methods This prospective pilot study enrolled patients with metastatic vertebral tumors treated between January 2018 and October 2019. The participants were randomized to the PVP and MWA + PVP groups. Clinical parameters, pain visual analog scale (VAS), analgesic use scores (AUS), and quality-of-life score (QLS) were compared between groups.

Results Sixty-seven participants were enrolled (PVP: n = 35; MWA + PVP: n = 32). There were no differences in bone cement injection volume, extravasation, and X-ray exposure time between the two groups (p > 0.05), but treatment costs were higher for the MWA + PVP group (26,418 ± 194 vs. 15,606 ± 148 yuan; p < 0.05). There were no significant improvements in VAS from baseline to 24 hours, 72 hours, 7 days, 1 month, and 3 months in the two groups (p > 0.05); at 6 and 12 months after the operation, the improvement from baseline was significant in the two groups (p < 0.05). The VAS was lower at 6 months (2.7 ± 0.7 vs. 3.2 ± 0.7) and 12 months (3.5 ± 0.8 vs. 4.0 ± 0.7) in the MWA + PVP group (both p < 0.01 vs. PVP). The AUS and QLS were improved with PVP at 6 and 12 months (p < 0.05) and with MWA + PVP at 12 months (p < 0.05). The AUS was lower at 6 and 12 months in the MWA + PVP group (p < 0.05 vs. PVP).

Conclusion MWA combined with PVP might be a safe and effective palliative treatment for pain from metastatic vertebral tumors.

Keywords

vertebra - metastasis - microwave ablation - percutaneous vertebroplasty - pain

Full Text

References

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