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J Neurol Surg B Skull Base 2023; 84(06): 629-636
DOI: 10.1055/s-0042-1756500
Original Article

Assessment of Four Serum Biochemical Markers in Elderly Patients with Vascular Dementia after Cerebral Infarction and Their Response to Donepezil and Idebenone

Jianlin Liu   *
1   Department of Neurology, Hubei Third People's Hospital of Jianghan University, Wuhan, China
,
Qin Li   *
1   Department of Neurology, Hubei Third People's Hospital of Jianghan University, Wuhan, China
,
Tao Peng
1   Department of Neurology, Hubei Third People's Hospital of Jianghan University, Wuhan, China
,
Qianwen Zhou
1   Department of Neurology, Hubei Third People's Hospital of Jianghan University, Wuhan, China
,
Bihua He
1   Department of Neurology, Hubei Third People's Hospital of Jianghan University, Wuhan, China
,
Bifeng Zhu 
1   Department of Neurology, Hubei Third People's Hospital of Jianghan University, Wuhan, China
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Abstract

Objective Our study aimed to explore four serum levels of biochemical markers, including brain-derived neurotrophic factor (BDNF), homocysteine (Hcy), nitric oxide (NO), and γ-interferon (IFN-γ), in elderly patients with vascular dementia (VD) after the cerebral infarction and to elucidate possible connections between them.

Method The elderly patients with VD after cerebral infarction admitted in our hospital, and the elderly persons for physical examination from November 2020 to December 2021 were included in this study. The serum levels of BDNF, Hcy, NO, and IFN-γ were compared between the study group and the control group.

Results In the study group, the serum levels of Hcy and IFN-γ were significantly higher than that in the control group, whereas significantly lower serum levels of BDNF and NO were found in the study group compared with the control group. After receiving the intervention of donepezil and/or idebenone, the serum levels of Hcy and IFN-γ in group B were significantly lower than that in group A, while the serum levels of BDNF and NO in group B were significantly higher than that in Group A.

Conclusion The results of our study showed abnormally expressed serum levels of Hcy, IFN-γ, BDNF, and NO in elderly patients with VD after cerebral infarction which might strongly reflect the severity of VD. Moreover, after intervention of donepezil alone or combined with idebenone, the changes of serum levels of Hcy, IFN-γ, BDNF, and NO may reflect the curative effect of the disease.

Keywords

brain-derived neurotrophic factor - homocysteine - nitric oxide - γ-interferon - vascular dementia - cerebral infarction - donepezil - idebenone

Ethics Approval and Consent to Participate

The study protocol was approved by the Ethics Committee of Hubei Third People's Hospital of Jianghan University. Informed consent was obtained from all the study subjects before enrollment.


Availability of Data and Materials

The datasets generated and analyzed during the current study are available from the corresponding author on reasonable request.


Authors' Contributions

J.L. and Q.L. have made substantial contributions to conception and design of the study. T.P. was involved in acquisition of data, data entry and data cleaning. Q.Z. was involved in analysis and interpretation of data. B.H. and B.Z. have been involved in drafting the manuscript. J.L. and Q.L. were involved in revising manuscript critically for important intellectual content. All authors contributed substantially to its revision. All authors read and approved the final manuscript.


* Jianlin Liu and Qin Li contributed equally to this paper.




Publication History

Received: 02 March 2022

Accepted: 03 August 2022

Article published online:
01 November 2022

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