Osteologie 2022; 31(03): 197
DOI: 10.1055/s-0042-1755845
Abstracts
Vorträge

Analysis of bone architecture using fractal-based TX-Analyzer in adult patients with osteogenesis imperfecta

Authors

  • A Daniel Kraus

    1   Ludwig Boltzmann Institute of Osteology at Hanusch Hospital of OEGK and AUVA Trauma Center Vienna-Meidling, Vienna, Austria
    2   Hanusch Hospital Vienna, I Medical Department, Vienna, Austria

  • Judith Haschka

    1   Ludwig Boltzmann Institute of Osteology at Hanusch Hospital of OEGK and AUVA Trauma Center Vienna-Meidling, Vienna, Austria
    2   Hanusch Hospital Vienna, I Medical Department, Vienna, Austria
    3   St. Vincent Hospital Vienna, II Medical Department, Vienna, Austria

  • Stephanie Huber

    1   Ludwig Boltzmann Institute of Osteology at Hanusch Hospital of OEGK and AUVA Trauma Center Vienna-Meidling, Vienna, Austria

  • E Jakob Schanda

    4   AUVA Trauma Center Vienna-Meidling, Department for Trauma Surgery, Vienna, Austria
    5   Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria
    6   Austrian Cluster for Tissue Regeneration, Vienna, Austria

  • Martina Behanova

    1   Ludwig Boltzmann Institute of Osteology at Hanusch Hospital of OEGK and AUVA Trauma Center Vienna-Meidling, Vienna, Austria

  • Philip Meier

    7   Image Biopsy Lab, Vienna, Austria

  • Arian Bahrami

    8   Hanusch Hospital Vienna, Department of Radiology and Nuclear Medicine, Vienna, Austria

  • Shahin Zandieh

    8   Hanusch Hospital Vienna, Department of Radiology and Nuclear Medicine, Vienna, Austria

  • Christian Muschitz

    3   St. Vincent Hospital Vienna, II Medical Department, Vienna, Austria

  • Heinrich Resch

    3   St. Vincent Hospital Vienna, II Medical Department, Vienna, Austria
    9   Sigmund Freud University Vienna, Medical Faculty of Bone Diseases, Vienna, Austria

  • Matthias Mähr

    1   Ludwig Boltzmann Institute of Osteology at Hanusch Hospital of OEGK and AUVA Trauma Center Vienna-Meidling, Vienna, Austria

  • Katharina Rötzer

    10   Hanusch Hospital Vienna, Department of Medical Genetics, Vienna, Austria
    11   Sigmund Freud University, Medical Faculty of Genetics, Vienna, Austria

  • Göykan Uyanik

    10   Hanusch Hospital Vienna, Department of Medical Genetics, Vienna, Austria
    11   Sigmund Freud University, Medical Faculty of Genetics, Vienna, Austria

  • Jochen Zwerina

    1   Ludwig Boltzmann Institute of Osteology at Hanusch Hospital of OEGK and AUVA Trauma Center Vienna-Meidling, Vienna, Austria
    2   Hanusch Hospital Vienna, I Medical Department, Vienna, Austria

  • Roland Kocijan

    1   Ludwig Boltzmann Institute of Osteology at Hanusch Hospital of OEGK and AUVA Trauma Center Vienna-Meidling, Vienna, Austria
    2   Hanusch Hospital Vienna, I Medical Department, Vienna, Austria
    9   Sigmund Freud University Vienna, Medical Faculty of Bone Diseases, Vienna, Austria
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Introduction Osteogenesis imperfecta is a rare genetic disorder characterized by impaired bone quality and quantity. TX-Analyzer is a new fractal-based technique assessing bone microstructure based on conventional radiographs. We explored whether TX-Analyzer can discriminate osteogenesis imperfecta patients from controls and investigated the correlation between TX-Analyzer and crucial imaging techniques.

Methods 29 osteogenesis imperfecta patients and 58 age- and gender-matched controls were analyzed. The parameters bone structure value, bone variance value and bone entropy value were measured at the vertebral bodies of T7 to L4. Furthermore, bone mineral density by dual energy x-ray absorptiometry, trabecular bone score and trabecular bone microstructure by high-resolution peripheral quantitative computed tomography were correlated to them. The accuracy of TX-Analyzer in detecting osteogenesis imperfecta was assessed with area under curve analysis of receiver operating characteristic.

Results Bone entropy value of thoracic and lumbar spine were significantly lower in osteogenesis imperfecta patients compared to controls (both p<0.001). Bone entropy value of the thoracic spine correlated significantly to trabecular bone score (ρ=0.427, p=0.042) as well as trabecular number (ρ=0.603, p=0.029) and inhomogeneity of the trabecular network (ρ=−0.610, p=0.027) at the radius. No correlations were found between bone entropy value and bone mineral density. Bone entropy value of thoracic and lumbar spine had an area under the curve of 0.81 (p<60;0.001) and 0.73 (p=0.008), respectively.

Discussion The TX-Analyzer can discriminate patients with osteogenesis imperfecta from controls. Low to no correlations with conventional methods suggest,that the TX-Analyzer may indicate a new and independent examination tool in osteogenesis imperfecta.

Keywords Osteogenesis imperfecta, TX-Analyzer, fractal-based analysis, bone microstructure, conventional radiography

Korrespondenzadresse Daniel Arian Kraus, Ludwig Boltzmann Institut für Osteologie, Heinrich-Collin-Straße 30, 1140 Wien, Österreich, E-Mail: daniel.arian.kraus@gmail.com



Publication History

Article published online:
08 September 2022

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